TLR5

This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease. [provided by RefSeq, Dec 2009]

Description

Toll like receptor 5

Tissue specificity

Tissue enhanced (ovary)

Subcell location

Nucleoplasm, Golgi apparatus, Cytosol

Predicted location

Intracellular, Membrane

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

1 (223109404 - 223143248)

Ensembl ID

ENSG00000187554  (ver. 103.38)

Orthologs

Mouse Tlr5: ENSMUSG00000079164

UniProt

O60602

neXtProt

NX_O60602

Human splice variants
Mouse splice variants

Protein structure