PDGFC

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]

Description

Platelet derived growth factor C

Tissue specificity

Tissue enhanced (parathyroid gland)

Subcell location

Plasma membrane, Cytosol

Predicted location

Secreted to blood

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
RAS pathway related proteins

Chromosome

4 (156760454 - 156971799)

Ensembl ID

ENSG00000145431  (ver. 103.38)

Orthologs

Mouse Pdgfc: ENSMUSG00000028019

UniProt

Q9NRA1

neXtProt

NX_Q9NRA1

Human splice variants
Mouse splice variants

Protein structure