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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [4]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- ABIN500070 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Immunity-Related GTPase Family, M (IRGM) antibody
- Antibody type
- Polyclonal
- Antigen
- Immunity-Related GTPase Family, M (IRGM)
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Antigen sequence
IRGM antibody was raised against a
14 amino acid peptide near the cent
er of the humanIRGM.- Isotype
- IgG
- Vial size
- 0.1 mg
Submitted references Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.
Genome-wide association scanning highlights two autophagy genes, ATG16L1 and IRGM, as being significantly associated with Crohn's disease.
Human IRGM induces autophagy to eliminate intracellular mycobacteria.
Autophagy as a cell death and tumor suppressor mechanism.
Fisher SA, Tremelling M, Anderson CA, Gwilliam R, Bumpstead S, Prescott NJ, Nimmo ER, Massey D, Berzuini C, Johnson C, Barrett JC, Cummings FR, Drummond H, Lees CW, Onnie CM, Hanson CE, Blaszczyk K, Inouye M, Ewels P, Ravindrarajah R, Keniry A, Hunt S, Carter M, Watkins N, Ouwehand W, Lewis CM, Cardon L, Wellcome Trust Case Control Consortium, Lobo A, Forbes A, Sanderson J, Jewell DP, Mansfield JC, Deloukas P, Mathew CG, Parkes M, Satsangi J
Nature genetics 2008 Jun;40(6):710-2
Nature genetics 2008 Jun;40(6):710-2
Genome-wide association scanning highlights two autophagy genes, ATG16L1 and IRGM, as being significantly associated with Crohn's disease.
Massey DC, Parkes M
Autophagy 2007 Nov-Dec;3(6):649-51
Autophagy 2007 Nov-Dec;3(6):649-51
Human IRGM induces autophagy to eliminate intracellular mycobacteria.
Singh SB, Davis AS, Taylor GA, Deretic V
Science (New York, N.Y.) 2006 Sep 8;313(5792):1438-41
Science (New York, N.Y.) 2006 Sep 8;313(5792):1438-41
Autophagy as a cell death and tumor suppressor mechanism.
Gozuacik D, Kimchi A
Oncogene 2004 Apr 12;23(16):2891-906
Oncogene 2004 Apr 12;23(16):2891-906
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Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- Western blot analysis of IRGM in human brain lysate with AP30455PU-N at (A) 1 and (B) 2 ?g/ml.
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- Immunohistochemistry of IRGM in human brain with AP30455PU-N at 5 ?g/ml.
