CHRM1

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq, Jul 2008]

Description

Cholinergic receptor muscarinic 1

Tissue specificity

Group enriched (brain, prostate, salivary gland)

Predicted location

Membrane

Protein family

FDA approved drug targets
G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

11 (62908679 - 62921807)

Ensembl ID

ENSG00000168539  (ver. 103.38)

Orthologs

Mouse Chrm1: ENSMUSG00000032773

UniProt

P11229

neXtProt

NX_P11229

Human splice variants
Mouse splice variants

Protein structure