HS6ST2

Heparan sulfate proteoglycans are ubiquitous components of the cell surface, extracellular matrix, and basement membranes, and interact with various ligands to influence cell growth, differentiation, adhesion, and migration. This gene encodes a member of the heparan sulfate (HS) sulfotransferase gene family, which catalyze the transfer of sulfate to HS. Different family members and isoforms are thought to synthesize heparan sulfates with tissue-specific structures and functions. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

Heparan sulfate 6-O-sulfotransferase 2

Tissue specificity

Tissue enhanced (brain, kidney, ovary)

Subcell location

Golgi apparatus

Predicted location

Intracellular, Membrane

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

X (132626016 - 132961395)

Ensembl ID

ENSG00000171004  (ver. 103.38)

Orthologs

Mouse Hs6st2: ENSMUSG00000062184

UniProt

Q96MM7

neXtProt

NX_Q96MM7

Human splice variants
Mouse splice variants

Protein structure