NAA10

N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes an N-terminal acetyltransferase that functions as the catalytic subunit of the major amino-terminal acetyltransferase A complex. Mutations in this gene are the cause of Ogden syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Description

N-alpha-acetyltransferase 10, NatA catalytic subunit

Tissue specificity

Low tissue specificity

Subcell location

Nucleoli, Cytosol

Predicted location

Intracellular

Protein family

Disease related genes
Enzymes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Potential drug targets
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

X (153929225 - 153935080)

Ensembl ID

ENSG00000102030  (ver. 103.38)

Orthologs

Mouse Naa10: ENSMUSG00000031388

UniProt

P41227

neXtProt

NX_P41227

Human splice variants
Mouse splice variants

Protein structure