KLK6

This gene encodes a member of the kallikrein subfamily of the peptidase S1 family of serine proteases. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The encoded preproprotein is proteolytically processed to generate the mature protease. Expression of this protease is regulated by steroid hormones and may be elevated in multiple human cancers and in serum from psoriasis patients. The encoded protease may participate in the cleavage of amyloid precursor protein and alpha-synuclein, thus implicating this protease in Alzheimer's and Parkinson's disease, respectively. This gene is located in a gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

Description

Kallikrein related peptidase 6

Tissue specificity

Tissue enhanced (brain, esophagus)

Subcell location

Nucleoplasm, Nuclear membrane, Cytokinetic bridge

Predicted location

Intracellular, Secreted in other tissues

Protein family

Cancer-related genes
Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

19 (50958631 - 50969673)

Ensembl ID

ENSG00000167755  (ver. 103.38)

Orthologs

Mouse Klk6: ENSMUSG00000050063

UniProt

Q92876

neXtProt

NX_Q92876

Human splice variants
Mouse splice variants

Protein structure