BS6049

antibody from Bioworld Technology, Inc
Targeting: MGMT
Provider product page for BS6049
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS6049 - Provider product page
Provider
Bioworld Technology, Inc
Product name
MGMT polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human MGMT.
Description
MGMT (O6-methylguanine-DNA methyltransferase) is transcriptionally activated in response to DNA damage and functions to repair mutagenic and cytotoxic O6-alkylguanine lesions caused by carcinogens or cytostatic drugs. MGMT induction by ionising radiation does not occur in p53-deficient mice, suggesting that MGMT induction may require p53. Similarly, MGMT mRNA and protein were shown to be inducible by ionising radiation only in cell lines that express functional p53, and not in cell lines that do not express wild type p53. In contrast, in a study of oral cancer cell lines, high MGMT activity was associated with the presence of mutant p53. Similarly, MGMT activity was significantly lower in ovarian tumors with wild-type p53 than in tumors with mutant p53, supporting the view that wild type p53 down-regulates the basal MGMT promoter.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
MGMT protein structure - BS6049 shown in red.