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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [29]
- Comments [0]
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- Product number
- ALX-804-093-R100 - Provider product page
- Provider
- Enzo Life Sciences
- Proper citation
- Enzo Life Sciences Cat#ALX-804-093-R100, RRID:AB_2052228
- Product name
- Phospholamban, mAb (2D12)
- Antibody type
- Monoclonal
- Antigen
- Synthetic peptide
- Description
- Protein A-affinity purified. Liquid. In PBS containing 0.05% sodium azide.
- Isotype
- IgG
- Antibody clone number
- 2D12
- Vial size
- 100 µl
Submitted references Differential activation of stress-response signaling in load-induced cardiac hypertrophy and failure.
Chronic ventricular myocyte-specific overexpression of angiotensin II type 2 receptor results in intrinsic myocyte contractile dysfunction.
Genetic manipulation of calcium-handling proteins in cardiac myocytes. I. Experimental studies.
Adenylyl cyclase type VI gene transfer reduces phospholamban expression in cardiac myocytes via activating transcription factor 3.
Doxycycline inducible expression of SERCA2a improves calcium handling and reverts cardiac dysfunction in pressure overload-induced cardiac hypertrophy.
The Na(+)-K(+)-ATPase alpha2-subunit isoform modulates contractility in the perinatal mouse diaphragm.
Alterations in myofilament function contribute to left ventricular dysfunction in pigs early after myocardial infarction.
Frequency- and afterload-dependent cardiac modulation in vivo by troponin I with constitutively active protein kinase A phosphorylation sites.
Sarcoplasmic reticulum calcium defect in Ras-induced hypertrophic cardiomyopathy heart.
Autologous stem cell transplantation for myocardial repair.
Nitric oxide protects cardiac sarcolemmal membrane enzyme function and ion active transport against ischemia-induced inactivation.
Mechanism of enhanced cardiac function in mice with hypertrophy induced by overexpressed Akt.
Targeted inhibition of Ca2+/calmodulin-dependent protein kinase II in cardiac longitudinal sarcoplasmic reticulum results in decreased phospholamban phosphorylation at threonine 17.
Regional alterations in protein expression in the dyssynchronous failing heart.
Altered dose response to beta-agonists in SERCA1a-expressing hearts ex vivo and in vivo.
Defective intracellular Ca(2+) signaling contributes to cardiomyopathy in Type 1 diabetic rats.
Abnormal Ca2+ release, but normal ryanodine receptors, in canine and human heart failure.
Type 1 phosphatase, a negative regulator of cardiac function.
Ca(2+) signaling in cardiac myocytes overexpressing the alpha(1) subunit of L-type Ca(2+) channel.
Targeting phospholamban by gene transfer in human heart failure.
Interaction between increased SERCA2a activity and beta -adrenoceptor stimulation in adult rabbit myocytes.
Overexpression of the sarcoplasmic reticulum Ca(2+)-ATPase improves myocardial contractility in diabetic cardiomyopathy.
Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, I: experimental studies.
Molecular and physiological alterations in murine ventricular dysfunction.
Residues 2-25 of phospholamban are insufficient to inhibit Ca2+ transport ATPase of cardiac sarcoplasmic reticulum.
The Ca2+-release channel/ryanodine receptor is localized in junctional and corbular sarcoplasmic reticulum in cardiac muscle.
Comparative studies of cardiac and skeletal sarcoplasmic reticulum ATPases. Effect of a phospholamban antibody on enzyme activation by Ca2+.
Phospholamban expressed in slow-twitch and chronically stimulated fast-twitch muscles minimally affects calcium affinity of sarcoplasmic reticulum Ca(2+)-ATPase.
Phospholamban mediates the beta-adrenergic-enhanced Ca2+ uptake in mammalian ventricular myocytes.
Rothermel BA, Berenji K, Tannous P, Kutschke W, Dey A, Nolan B, Yoo KD, Demetroulis E, Gimbel M, Cabuay B, Karimi M, Hill JA
Physiological genomics 2005 Sep 21;23(1):18-27
Physiological genomics 2005 Sep 21;23(1):18-27
Chronic ventricular myocyte-specific overexpression of angiotensin II type 2 receptor results in intrinsic myocyte contractile dysfunction.
Nakayama M, Yan X, Price RL, Borg TK, Ito K, Sanbe A, Robbins J, Lorell BH
American journal of physiology. Heart and circulatory physiology 2005 Jan;288(1):H317-27
American journal of physiology. Heart and circulatory physiology 2005 Jan;288(1):H317-27
Genetic manipulation of calcium-handling proteins in cardiac myocytes. I. Experimental studies.
Coutu P, Metzger JM
American journal of physiology. Heart and circulatory physiology 2005 Feb;288(2):H601-12
American journal of physiology. Heart and circulatory physiology 2005 Feb;288(2):H601-12
Adenylyl cyclase type VI gene transfer reduces phospholamban expression in cardiac myocytes via activating transcription factor 3.
Gao MH, Tang T, Guo T, Sun SQ, Feramisco JR, Hammond HK
The Journal of biological chemistry 2004 Sep 10;279(37):38797-802
The Journal of biological chemistry 2004 Sep 10;279(37):38797-802
Doxycycline inducible expression of SERCA2a improves calcium handling and reverts cardiac dysfunction in pressure overload-induced cardiac hypertrophy.
Suarez J, Gloss B, Belke DD, Hu Y, Scott B, Dieterle T, Kim YK, Valencik ML, McDonald JA, Dillmann WH
American journal of physiology. Heart and circulatory physiology 2004 Nov;287(5):H2164-72
American journal of physiology. Heart and circulatory physiology 2004 Nov;287(5):H2164-72
The Na(+)-K(+)-ATPase alpha2-subunit isoform modulates contractility in the perinatal mouse diaphragm.
Radzyukevich TL, Moseley AE, Shelly DA, Redden GA, Behbehani MM, Lingrel JB, Paul RJ, Heiny JA
American journal of physiology. Cell physiology 2004 Nov;287(5):C1300-10
American journal of physiology. Cell physiology 2004 Nov;287(5):C1300-10
Alterations in myofilament function contribute to left ventricular dysfunction in pigs early after myocardial infarction.
van der Velden J, Merkus D, Klarenbeek BR, James AT, Boontje NM, Dekkers DH, Stienen GJ, Lamers JM, Duncker DJ
Circulation research 2004 Nov 26;95(11):e85-95
Circulation research 2004 Nov 26;95(11):e85-95
Frequency- and afterload-dependent cardiac modulation in vivo by troponin I with constitutively active protein kinase A phosphorylation sites.
Takimoto E, Soergel DG, Janssen PM, Stull LB, Kass DA, Murphy AM
Circulation research 2004 Mar 5;94(4):496-504
Circulation research 2004 Mar 5;94(4):496-504
Sarcoplasmic reticulum calcium defect in Ras-induced hypertrophic cardiomyopathy heart.
Zheng M, Dilly K, Dos Santos Cruz J, Li M, Gu Y, Ursitti JA, Chen J, Ross J Jr, Chien KR, Lederer JW, Wang Y
American journal of physiology. Heart and circulatory physiology 2004 Jan;286(1):H424-33
American journal of physiology. Heart and circulatory physiology 2004 Jan;286(1):H424-33
Autologous stem cell transplantation for myocardial repair.
Liu J, Hu Q, Wang Z, Xu C, Wang X, Gong G, Mansoor A, Lee J, Hou M, Zeng L, Zhang JR, Jerosch-Herold M, Guo T, Bache RJ, Zhang J
American journal of physiology. Heart and circulatory physiology 2004 Aug;287(2):H501-11
American journal of physiology. Heart and circulatory physiology 2004 Aug;287(2):H501-11
Nitric oxide protects cardiac sarcolemmal membrane enzyme function and ion active transport against ischemia-induced inactivation.
Xu KY, Kuppusamy SP, Wang JQ, Li H, Cui H, Dawson TM, Huang PL, Burnett AL, Kuppusamy P, Becker LC
The Journal of biological chemistry 2003 Oct 24;278(43):41798-803
The Journal of biological chemistry 2003 Oct 24;278(43):41798-803
Mechanism of enhanced cardiac function in mice with hypertrophy induced by overexpressed Akt.
Kim YK, Kim SJ, Yatani A, Huang Y, Castelli G, Vatner DE, Liu J, Zhang Q, Diaz G, Zieba R, Thaisz J, Drusco A, Croce C, Sadoshima J, Condorelli G, Vatner SF
The Journal of biological chemistry 2003 Nov 28;278(48):47622-8
The Journal of biological chemistry 2003 Nov 28;278(48):47622-8
Targeted inhibition of Ca2+/calmodulin-dependent protein kinase II in cardiac longitudinal sarcoplasmic reticulum results in decreased phospholamban phosphorylation at threonine 17.
Ji Y, Li B, Reed TD, Lorenz JN, Kaetzel MA, Dedman JR
The Journal of biological chemistry 2003 Jul 4;278(27):25063-71
The Journal of biological chemistry 2003 Jul 4;278(27):25063-71
Regional alterations in protein expression in the dyssynchronous failing heart.
Spragg DD, Leclercq C, Loghmani M, Faris OP, Tunin RS, DiSilvestre D, McVeigh ER, Tomaselli GF, Kass DA
Circulation 2003 Aug 26;108(8):929-32
Circulation 2003 Aug 26;108(8):929-32
Altered dose response to beta-agonists in SERCA1a-expressing hearts ex vivo and in vivo.
Huke S, Prasad V, Nieman ML, Nattamai KJ, Grupp IL, Lorenz JN, Periasamy M
American journal of physiology. Heart and circulatory physiology 2002 Sep;283(3):H958-65
American journal of physiology. Heart and circulatory physiology 2002 Sep;283(3):H958-65
Defective intracellular Ca(2+) signaling contributes to cardiomyopathy in Type 1 diabetic rats.
Choi KM, Zhong Y, Hoit BD, Grupp IL, Hahn H, Dilly KW, Guatimosim S, Lederer WJ, Matlib MA
American journal of physiology. Heart and circulatory physiology 2002 Oct;283(4):H1398-408
American journal of physiology. Heart and circulatory physiology 2002 Oct;283(4):H1398-408
Abnormal Ca2+ release, but normal ryanodine receptors, in canine and human heart failure.
Jiang MT, Lokuta AJ, Farrell EF, Wolff MR, Haworth RA, Valdivia HH
Circulation research 2002 Nov 29;91(11):1015-22
Circulation research 2002 Nov 29;91(11):1015-22
Type 1 phosphatase, a negative regulator of cardiac function.
Carr AN, Schmidt AG, Suzuki Y, del Monte F, Sato Y, Lanner C, Breeden K, Jing SL, Allen PB, Greengard P, Yatani A, Hoit BD, Grupp IL, Hajjar RJ, DePaoli-Roach AA, Kranias EG
Molecular and cellular biology 2002 Jun;22(12):4124-35
Molecular and cellular biology 2002 Jun;22(12):4124-35
Ca(2+) signaling in cardiac myocytes overexpressing the alpha(1) subunit of L-type Ca(2+) channel.
Song LS, Guia A, Muth JN, Rubio M, Wang SQ, Xiao RP, Josephson IR, Lakatta EG, Schwartz A, Cheng H
Circulation research 2002 Feb 8;90(2):174-81
Circulation research 2002 Feb 8;90(2):174-81
Targeting phospholamban by gene transfer in human heart failure.
del Monte F, Harding SE, Dec GW, Gwathmey JK, Hajjar RJ
Circulation 2002 Feb 26;105(8):904-7
Circulation 2002 Feb 26;105(8):904-7
Interaction between increased SERCA2a activity and beta -adrenoceptor stimulation in adult rabbit myocytes.
Chaudhri B, Del Monte F, Hajjar RJ, Harding SE
American journal of physiology. Heart and circulatory physiology 2002 Dec;283(6):H2450-7
American journal of physiology. Heart and circulatory physiology 2002 Dec;283(6):H2450-7
Overexpression of the sarcoplasmic reticulum Ca(2+)-ATPase improves myocardial contractility in diabetic cardiomyopathy.
Trost SU, Belke DD, Bluhm WF, Meyer M, Swanson E, Dillmann WH
Diabetes 2002 Apr;51(4):1166-71
Diabetes 2002 Apr;51(4):1166-71
Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, I: experimental studies.
O'Rourke B, Kass DA, Tomaselli GF, Kääb S, Tunin R, Marbán E
Circulation research 1999 Mar 19;84(5):562-70
Circulation research 1999 Mar 19;84(5):562-70
Molecular and physiological alterations in murine ventricular dysfunction.
Rockman HA, Ono S, Ross RS, Jones LR, Karimi M, Bhargava V, Ross J Jr, Chien KR
Proceedings of the National Academy of Sciences of the United States of America 1994 Mar 29;91(7):2694-8
Proceedings of the National Academy of Sciences of the United States of America 1994 Mar 29;91(7):2694-8
Residues 2-25 of phospholamban are insufficient to inhibit Ca2+ transport ATPase of cardiac sarcoplasmic reticulum.
Jones LR, Field LJ
The Journal of biological chemistry 1993 Jun 5;268(16):11486-8
The Journal of biological chemistry 1993 Jun 5;268(16):11486-8
The Ca2+-release channel/ryanodine receptor is localized in junctional and corbular sarcoplasmic reticulum in cardiac muscle.
Jorgensen AO, Shen AC, Arnold W, McPherson PS, Campbell KP
The Journal of cell biology 1993 Feb;120(4):969-80
The Journal of cell biology 1993 Feb;120(4):969-80
Comparative studies of cardiac and skeletal sarcoplasmic reticulum ATPases. Effect of a phospholamban antibody on enzyme activation by Ca2+.
Cantilina T, Sagara Y, Inesi G, Jones LR
The Journal of biological chemistry 1993 Aug 15;268(23):17018-25
The Journal of biological chemistry 1993 Aug 15;268(23):17018-25
Phospholamban expressed in slow-twitch and chronically stimulated fast-twitch muscles minimally affects calcium affinity of sarcoplasmic reticulum Ca(2+)-ATPase.
Briggs FN, Lee KF, Wechsler AW, Jones LR
The Journal of biological chemistry 1992 Dec 25;267(36):26056-61
The Journal of biological chemistry 1992 Dec 25;267(36):26056-61
Phospholamban mediates the beta-adrenergic-enhanced Ca2+ uptake in mammalian ventricular myocytes.
Sham JS, Jones LR, Morad M
The American journal of physiology 1991 Oct;261(4 Pt 2):H1344-9
The American journal of physiology 1991 Oct;261(4 Pt 2):H1344-9
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