614202

antibody from BioLegend
Targeting: TP53 LFS1, p53
Provider product page for 614202

Antibody data

Product number
614202 - Provider product page
Provider
BioLegend
Product name
Purified anti-p53-Acetylated (Lys382)
Antibody type
Polyclonal
Antigen
Modified peptide
Description
p53 is a 53 kD protein that forms tetramers and functions as a tumor suppressor and transcriptional activator of genes that inhibit growth and/or invasion, cell cycle checkpoint after irradiation, DNA repair, apoptotic induction, signal transduction, and cell adhesion. This protein is localized to the nucleus when activated and can be upregulated by genotoxic or other cellular stresses. p53 is modified by phosphorylation, acetylation, ribosylation, ubiquitination, and sumoylation; ubiquination targets p53 for degradation via mdm2. This protein interacts with a variety of proteins including mdm2, mdmx, topoisomerase I, PML3, Bcl-XL, Bcl-2, Chk1, JNK, p38, HIPK2, CK2, DNA-PK, p300/CBP, PCAF, PARP1, and HDAC1-3. Mutant p53 associates with p63 and p73. The Poly6142 antibody recognizes human acetylated p53 (Lys382) and has been shown to be useful for Western blotting.
Reactivity
Human
Host
Rabbit
Conjugate
Unconjugated
Vial size
200 µl
Storage
Upon receipt, store frozen at -20° C.
TP53 protein structure - 614202 shown in red.