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Cell line expression
Protein structure
TP53
Tumor protein p53LFS1, p53
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]
Top validated antibodies |
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| GeneTex |  GTX70214 |
10 references | Monoclonal |
WB
EL
ICC
IP
IHC
FC
ChIP
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| Novus Biologicals | NB200-104 |
4 references | Monoclonal |
WB
EL
ICC
IP
IHC
FC
RA
ChIP
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| Invitrogen Antibodies | MA5-12554 |
138 references | Monoclonal |
WB
ICC
IHC
FC
OA
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| Proteintech Group | 10442-1-AP |
514 references | Polyclonal |
WB
EL
ICC
IP
IHC
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| antibodies-online | ABIN152309 |
7 references | Polyclonal |
WB
ICC
IP
IHC
FC
ChIP
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