Ab119827

antibody from Aladdin Scientific Corporation

Targeting: TP53 LFS1, p53

Western blot (Data presented on provider website)

Antibody Data

Product number

Ab119827

Provider

Aladdin Scientific Corporation

Product name

p53 Mouse mAb

Antibody type

Monoclonal

Description

Mouse anti Human p53 Antibody, Monoclonal (D1), could be used for WB and so on. Application WB: 0.01-2 µg/mL Protein Function Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.

Reactivity

Human, Rat

Host

Mouse

Conjugate

Unconjugated

Antigen sequence

AA 133-393


Antibody clone number

D1

Vial size

100μl,10μl,1ml,20μl,50μl

Concentration

Lot by Lot

Storage

Store at 4℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.