CCR3

The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]

Description

C-C motif chemokine receptor 3

Tissue specificity

Tissue enhanced (intestine)

Subcell location

Plasma membrane

Predicted location

Intracellular, Membrane

Protein family

CD markers
G-protein coupled receptors
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins

Chromosome

3 (46163604 - 46266706)

Ensembl ID

ENSG00000183625  (ver. 103.38)

Orthologs

Mouse Ccr3: ENSMUSG00000035448

UniProt

P51677

neXtProt

NX_P51677

Human splice variants
Mouse splice variants

Protein structure