CRYAB

gene product
CRYA2, HSPB5
Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
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566 antibodies from 28 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
OriGene
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55 antibodies
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17 antibodies
Proteintech Group
1 antibody
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Acris Antibodies GmbH
19 antibodies
Abnova Corporation
16 antibodies
Biorbyt
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Abgent
6 antibodies
Thermo Fisher Scientific Pierce
8 antibodies
Aviva Systems Biology
8 antibodies
Atlas Antibodies
1 antibody
RabMAbs
4 antibodies
Creative Biomart
35 antibodies
Everest Biotech
1 antibody
R&D Systems
2 antibodies
Rockland Immunochemicals, Inc.
2 antibodies
RayBiotech, Inc.
9 antibodies
Enzo Life Sciences
12 antibodies
Bioworld Technology, Inc
4 antibodies
GenWay
4 antibodies
Cell Signaling Technology, Inc
1 antibody
United States Biological
10 antibodies
Sigma-Aldrich
6 antibodies
EMD Millipore
2 antibodies
Abbiotec
1 antibody
BioLegend (formerly Covance Antibody Products)
1 antibody