CRYAB

gene product
CRYA2, HSPB5
Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
More gene data

Featured antibodies

Antibodies

 

Filters

Knockdown Initiative

Application

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

  or   Clear
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Validated in Knockdown Initative
Eligible for validation in KDI
800 antibodies from 29 providers.

Antibody properties

Applications

or Cancel
AntibodyRefsTypeKDWBELICCIPIHCFC
OriGene
16 antibodies
antibodies-online
323 antibodies
Novus Biologicals
57 antibodies
GeneTex
16 antibodies
Enzo Life Sciences
12 antibodies
Thermo Fisher Scientific Pierce
8 antibodies
Abnova Corporation
16 antibodies
Proteintech Group
1 antibody
LifeSpan BioSciences, Inc.
101 antibodies
Acris Antibodies GmbH
19 antibodies
Biorbyt
81 antibodies
Abgent
7 antibodies
Aviva Systems Biology
8 antibodies
Atlas Antibodies
1 antibody
Bioworld Technology, Inc
4 antibodies
RabMAbs
4 antibodies
Everest Biotech
1 antibody
R&D Systems
2 antibodies
Rockland Immunochemicals, Inc.
2 antibodies
RayBiotech, Inc.
9 antibodies
Creative Diagnostics
15 antibodies