60160

antibody from STEMCELL Technologies Inc

Targeting: CD27 S152, TNFRSF7, Tp55

Immunoprecipitation (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Functional assay (Recommended by provider)

Antibody Data

Product number

60160

Provider

STEMCELL Technologies Inc

Product name

Anti-Mouse CD27 Antibody, Clone LG.3A10

Antibody type

Monoclonal

Description

The LG.3A10 antibody reacts with CD27, a 45 - 55 kDa member of the tumor necrosis factor receptor superfamily. CD27 is found on peripheral T cells, memory B cells, and NK cells and in mice has been found on most thymocytes, except CD46-CD8- precursors. CD27 and its ligand CD70 are involved in multiple aspects of T cell biology, including the costimulation and expansion of CD4+ and CD8+ T cells and differentiation to memory CD8+ T cells. CD27 interacts with TRAF family members, resulting in enhanced cellular proliferation and the induction of anti-apoptotic proteins. Additionally, CD27 plays important roles in T cell – B cell interactions and the maturation of effector T cells. The expansion of activated B cells and their differentiation to plasma cells is also reported to be enhanced by CD27.

Reactivity

Human, Mouse, Rat

Vial size

500 µg

Storage

2 - 8°C