Tissue expression
Cell line expression
Protein structure
CD27
CD27 moleculeS152, TNFRSF7, Tp55
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]
Top validated antibodies |
|||||
Invitrogen Antibodies | A700-083 | Monoclonal |
WB
ICC
IP
IHC
FC
OA |
||
NSJ Bioreagents | V8229 | Monoclonal |
EL
ICC
IHC
FC
PA
OA |
||
R&D Systems | AF382 | 2 references | Polyclonal |
WB
IHC
FC
BN |
|
Novus Biologicals | AF382 | 2 references | Polyclonal |
WB
IHC
FC
BN |
|
antibodies-online | ABIN2659846 | Monoclonal |
WB
ICC
IP
IHC
FC
|
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