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Cell line expression
Protein structure
E2F1
E2F transcription factor 1RBBP3, RBP3
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| Invitrogen Antibodies |  32-1400 |
11 references | Monoclonal |
WB
IP
IHC
FC
ChIP
OA
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| antibodies-online | ABIN1491636 |
Monoclonal |
WB
EL
ICC
IP
IHC
FC
ChIP
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| Novus Biologicals | NBP2-37474 |
1 references | Monoclonal |
WB
EL
IHC
FC
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| Proteintech Group | 12171-1-AP |
45 references | Polyclonal |
WB
EL
IHC
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| GeneTex | GTX70163 |
1 references | Monoclonal |
WB
ICC
IP
IHC
|
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