Tissue expression
Cell line expression
Protein structure
LRP6
LDL receptor related protein 6ADCAD2
This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined. [provided by RefSeq, Dec 2009]
Top validated antibodies |
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Invitrogen Antibodies | PA5-89161 | 1 references | Polyclonal |
WB
ICC
IHC
|
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Novus Biologicals | NB100-1475 | 3 references | Polyclonal |
WB
EL
IHC
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Biorbyt | orb2239918 | Polyclonal |
WB
EL
IP
IHC
FC
|
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antibodies-online | ABIN2840612 | 4 references | Polyclonal |
WB
IHC |
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R&D Systems | AF1505 | 4 references | Polyclonal |
WB
FC |
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Supportive data in Antibodypedia
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Recommended by provider