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- Immunohistochemistry [1]
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- Product number
- MAB944 - Provider product page
- Provider
- R&D Systems
- Product name
- Human Desmoglein-1 Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects human Desmoglein-1 in direct ELISAs and Western blots. Does not cross-react with recombinant human (rh) Desmoglein-2 or rhDesmoglein-3.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Antigen sequence
Q02413- Isotype
- IgG
- Antibody clone number
- 129204
- Vial size
- 500 ug
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Streptococcal Cysteine Protease-Mediated Cleavage of Desmogleins Is Involved in the Pathogenesis of Cutaneous Infection.
Desmoglein versus non-desmoglein signaling in pemphigus acantholysis: characterization of novel signaling pathways downstream of pemphigus vulgaris antigens.
Sumitomo T, Mori Y, Nakamura Y, Honda-Ogawa M, Nakagawa S, Yamaguchi M, Matsue H, Terao Y, Nakata M, Kawabata S
Frontiers in cellular and infection microbiology 2018;8:10
Frontiers in cellular and infection microbiology 2018;8:10
Desmoglein versus non-desmoglein signaling in pemphigus acantholysis: characterization of novel signaling pathways downstream of pemphigus vulgaris antigens.
Chernyavsky AI, Arredondo J, Kitajima Y, Sato-Nagai M, Grando SA
The Journal of biological chemistry 2007 May 4;282(18):13804-12
The Journal of biological chemistry 2007 May 4;282(18):13804-12
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Supportive validation
- Submitted by
- R&D Systems (provider)
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- Experimental details
- Desmoglein-1 in Human Skin Hyperplasia. Desmoglein-1 was detected in immersion fixed paraffin-embedded sections of human skin hyperplasia using Mouse Anti-Human Desmoglein-1 Monoclonal Antibody (Catalog # MAB944) at 5 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Mouse IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC001). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to keratinocyte membranes. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.
