Explore
Validate
LearnNB100-2323
antibody from Novus Biologicals
Targeting: ERN1
IRE1, IRE1P
Western blot
ELISA Immunocytochemistry Immunoprecipitation Immunohistochemistry Chromatin ImmunoprecipitationAntibody data
- Antibody Data
- Antigen structure
- References [208]
- Comments [0]
- Validations
- Western blot [6]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
Report error
- Product number
- NB100-2323 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB100-2323, RRID:AB_10145203
- Product name
- Rabbit Polyclonal IRE1 alpha Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. NB100-2323 IRE1 alpha [p Ser724] Antibody detects IRE-1 alpha when phosphorylated at Ser724 residue.
- Reactivity
- Human, Mouse, Rat, Drosophila, Goat, Porcine, Rabbit, Simian
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Concentration
- 1.0 mg/ml
- Storage
- Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Submitted references Endoplasmic reticulum stress mediates resistance to BCL-2 inhibitor in uveal melanoma cells.
Sodium tanshinone IIA sulfonate protects against Aβ1-42-induced cellular toxicity by modulating Aβ-degrading enzymes in HT22 cells.
Molecular changes in hepatic metabolism in ZDSD rats-A new polygenic rodent model of obesity, metabolic syndrome, and diabetes.
Effects of compound K, a metabolite of ginsenosides, on memory and cognitive dysfunction in db/db mice involve the inhibition of ER stress and the NLRP3 inflammasome pathway.
Interplay between Endoplasmic Reticulum (ER) Stress and Autophagy Induces Mutant p53H273 Degradation.
Paneth cell α-defensin misfolding correlates with dysbiosis and ileitis in Crohn's disease model mice.
Neferine alleviates memory and cognitive dysfunction in diabetic mice through modulation of the NLRP3 inflammasome pathway and alleviation of endoplasmic-reticulum stress.
Activation of pH-Sensing Receptor OGR1 (GPR68) Induces ER Stress Via the IRE1α/JNK Pathway in an Intestinal Epithelial Cell Model.
Calpain Activation Is the Major Cause of Cell Death in Photoreceptors Expressing a Rhodopsin Misfolding Mutation.
Repression of viral gene expression and replication by the unfolded protein response effector XBP1u.
Intracellular proliferation of Anaplasma phagocytophilum is promoted via modulation of endoplasmic reticulum stress signaling in host cells.
The unc-51 like autophagy activating kinase 1-autophagy related 13 complex has distinct functions in tunicamycin-treated cells.
TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation.
Disulfide bond-disrupting agents activate the tumor necrosis family-related apoptosis-inducing ligand/death receptor 5 pathway.
The IRE1α Arm of UPR Regulates Muscle Cells Immune Characters by Restraining p38 MAPK Activation.
Hepatic nitric oxide synthase 1 adaptor protein regulates glucose homeostasis and hepatic insulin sensitivity in obese mice depending on its PDZ binding domain.
Hypoxic ER stress suppresses β-catenin expression and promotes cooperation between the transcription factors XBP1 and HIF1α for cell survival.
Ebola virus-mediated T-lymphocyte depletion is the result of an abortive infection.
IRE1 promotes neurodegeneration through autophagy-dependent neuron death in the Drosophila model of Parkinson's disease.
Group VIA phospholipase A2 deficiency in mice chronically fed with high-fat-diet attenuates hepatic steatosis by correcting a defect of phospholipid remodeling.
ATG5 and ATG7 induced autophagy interplays with UPR via PERK signaling.
Oxytocin Suppresses Inflammatory Responses Induced by Lipopolysaccharide through Inhibition of the eIF-2-ATF4 Pathway in Mouse Microglia.
Bladder cancer extracellular vesicles drive tumorigenesis by inducing the unfolded protein response in endoplasmic reticulum of nonmalignant cells.
Ameliorating Methylglyoxal-Induced Progenitor Cell Dysfunction for Tissue Repair in Diabetes.
PRKCSH contributes to tumorigenesis by selective boosting of IRE1 signaling pathway.
Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation.
ER-stress regulates macrophage polarization through pancreatic EIF-2alpha kinase.
Granulovacuolar degeneration bodies are neuron-selective lysosomal structures induced by intracellular tau pathology.
Profile of the unfolded protein response in rat cerebellar cortical development.
Prolonged high-fat-diet feeding promotes non-alcoholic fatty liver disease and alters gut microbiota in mice.
iPla2β Deficiency Suppresses Hepatic ER UPR, Fxr, and Phospholipids in Mice Fed with MCD Diet, Resulting in Exacerbated Hepatic Bile Acids and Biliary Cell Proliferation.
Nitrosative stress drives heart failure with preserved ejection fraction.
The Neuroprotection of Low-Dose Morphine in Cellular and Animal Models of Parkinson's Disease Through Ameliorating Endoplasmic Reticulum (ER) Stress and Activating Autophagy.
Estrogen Receptor β Agonist Attenuates Endoplasmic Reticulum Stress-Induced Changes in Social Behavior and Brain Connectivity in Mice.
Myristate-induced endoplasmic reticulum stress requires ceramide synthases 5/6 and generation of C14-ceramide in intestinal epithelial cells.
Genome-wide analyses reveal the IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation.
Heme scavenging reduces pulmonary endoplasmic reticulum stress, fibrosis, and emphysema.
Polysaccharide from Angelica sinensis protects H9c2 cells against oxidative injury and endoplasmic reticulum stress by activating the ATF6 pathway.
Endoplasmic Reticulum Chaperone GRP78 Protects Heart From Ischemia/Reperfusion Injury Through Akt Activation.
Curcumin induces endoplasmic reticulum stress-associated apoptosis in human papillary thyroid carcinoma BCPAP cells via disruption of intracellular calcium homeostasis.
The serine/threonine-protein kinase/endoribonuclease IRE1α protects the heart against pressure overload-induced heart failure.
Designing an effective drug combination for ER stress loading in cancer therapy using a real-time monitoring system.
The three branches of the unfolded protein response exhibit differential significance in breast cancer growth and stemness.
Farnesoid X receptor signaling activates the hepatic X-box binding protein 1 pathway in vitro and in mice.
Exosomal secretion of α-synuclein as protective mechanism after upstream blockage of macroautophagy.
Pharmacological stimulation of p53 with low-dose doxorubicin ameliorates diet-induced nonalcoholic steatosis and steatohepatitis.
Hepatic alcohol dehydrogenase deficiency induces pancreatic injury in chronic ethanol feeding model of deer mice.
Inhibition of endoplasmic reticulum stress in high-fat-diet-induced obese C57BL/6 mice: Efficacy of a novel extract from mulberry (Morus alba) leaves fermented with Cordyceps militaris.
TMED2 Potentiates Cellular IFN Responses to DNA Viruses by Reinforcing MITA Dimerization and Facilitating Its Trafficking.
IRE1α aggravates ischemia reperfusion injury of fatty liver by regulating phenotypic transformation of kupffer cells.
Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate.
The IRE1α-XBP1s pathway promotes insulin-stimulated glucose uptake in adipocytes by increasing PPARγ activity.
C-X-C Motif Chemokine 10 Impairs Autophagy and Autolysosome Formation in Non-alcoholic Steatohepatitis.
Point mutation in D8C domain of Tamm-Horsfall protein/uromodulin in transgenic mice causes progressive renal damage and hyperuricemia.
IRE1 signaling exacerbates Alzheimer's disease pathogenesis.
The combination of digoxin and GSK2606414 exerts synergistic anticancer activity against leukemia in vitro and in vivo.
Sodium 4-Phenylbutyrate Attenuates Myocardial Reperfusion Injury by Reducing the Unfolded Protein Response.
The metabolic ER stress sensor IRE1α suppresses alternative activation of macrophages and impairs energy expenditure in obesity.
Calpain mobilizes Atg9/Bif-1 vesicles from Golgi stacks upon autophagy induction by thapsigargin.
Attenuation of endoplasmic reticulum stress by caffeine ameliorates hyperoxia-induced lung injury.
α(7)β(1) Integrin regulation of gene transcription in skeletal muscle following an acute bout of eccentric exercise.
Astragaloside IV protects against podocyte injury via SERCA2-dependent ER stress reduction and AMPKα-regulated autophagy induction in streptozotocin-induced diabetic nephropathy.
The constitutive lipid droplet protein PLIN2 regulates autophagy in liver.
Activation of TGF-β signaling induces cell death via the unfolded protein response in Fuchs endothelial corneal dystrophy.
Burn-induced muscle metabolic derangements and mitochondrial dysfunction are associated with activation of HIF-1α and mTORC1: Role of protein farnesylation.
Sustained Activation of the Unfolded Protein Response Induces Cell Death in Fuchs' Endothelial Corneal Dystrophy.
A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1α stability.
The specialized proresolving lipid mediator maresin 1 protects hepatocytes from lipotoxic and hypoxia-induced endoplasmic reticulum stress.
Salubrinal protects human skin fibroblasts against UVB-induced cell death by blocking endoplasmic reticulum (ER) stress and regulating calcium homeostasis.
Ultrastructure and immunohistochemical characterization of proteins concerned with the secretory machinery in goat ceruminous glands.
Wfs1- deficient rats develop primary symptoms of Wolfram syndrome: insulin-dependent diabetes, optic nerve atrophy and medullary degeneration.
Sigmar1 regulates endoplasmic reticulum stress-induced C/EBP-homologous protein expression in cardiomyocytes.
IER3IP1 deficiency leads to increased β-cell death and decreased β-cell proliferation.
Astragaloside IV Attenuates Podocyte Apoptosis Mediated by Endoplasmic Reticulum Stress through Upregulating Sarco/Endoplasmic Reticulum Ca2+-ATPase 2 Expression in Diabetic Nephropathy.
Role of chemokine C-C motif ligand-1 in acute and chronic pulmonary inflammations.
Effects of a Sublethal and Transient Stress of the Endoplasmic Reticulum on the Mitochondrial Population.
A super gene expression system enhances the anti-glioma effects of adenovirus-mediated REIC/Dkk-3 gene therapy.
Activation of the unfolded protein response and granulovacuolar degeneration are not common features of human prion pathology.
MicroRNA-124 promotes hepatic triglyceride accumulation through targeting tribbles homolog 3.
The small molecule '1-(4-biphenylylcarbonyl)-4-(5-bromo-2-methoxybenzyl) piperazine oxalate' and its derivatives regulate global protein synthesis by inactivating eukaryotic translation initiation factor 2-alpha.
Global quantitative proteomics reveal up-regulation of endoplasmic reticulum stress response proteins upon depletion of eIF5A in HeLa cells.
Vitamin C modulates the metabolic and cytokine profiles, alleviates hepatic endoplasmic reticulum stress, and increases the life span of Gulo-/- mice.
Carnosic acid slows photoreceptor degeneration in the Pde6b(rd10) mouse model of retinitis pigmentosa.
Maternal obesity alters endoplasmic reticulum homeostasis in offspring pancreas.
Carboxylesterase 2 prevents liver steatosis by modulating lipolysis, endoplasmic reticulum stress, and lipogenesis and is regulated by hepatocyte nuclear factor 4 alpha in mice.
Endoplasmic reticulum-associated degradation of the mouse PC1/3-N222D hypomorph and human PCSK1 mutations contributes to obesity.
Asymmetric dimethylarginine (ADMA) treatment induces apoptosis in cultured rat mesangial cells via endoplasmic reticulum stress activation.
Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2α, IRE1α, ATF6 and calmodulin kinase.
IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation.
Intravenous Lipid Infusion Induces Endoplasmic Reticulum Stress in Endothelial Cells and Blood Mononuclear Cells of Healthy Adults.
Limited Unfolded Protein Response and Inflammation in Neuroserpinopathy.
Salidroside Protects Against 6-Hydroxydopamine-Induced Cytotoxicity by Attenuating ER Stress.
Imiquimod-induced apoptosis of melanoma cells is mediated by ER stress-dependent Noxa induction and enhanced by NF-κB inhibition.
Alkylating Agent-Induced NRF2 Blocks Endoplasmic Reticulum Stress-Mediated Apoptosis via Control of Glutathione Pools and Protein Thiol Homeostasis.
VCP inhibitors induce endoplasmic reticulum stress, cause cell cycle arrest, trigger caspase-mediated cell death and synergistically kill ovarian cancer cells in combination with Salubrinal.
Knockout of inositol-requiring enzyme 1α in pro-opiomelanocortin neurons decreases fat mass via increasing energy expenditure.
β-Asarone Inhibits IRE1/XBP1 Endoplasmic Reticulum Stress Pathway in 6-OHDA-Induced Parkinsonian Rats.
Spontaneous nonalcoholic fatty liver disease and ER stress in Sidt2 deficiency mice.
Ursodeoxycholic Acid Ameliorated Diabetic Nephropathy by Attenuating Hyperglycemia-Mediated Oxidative Stress.
Cytokines Regulate β-Cell Thioredoxin-interacting Protein (TXNIP) via Distinct Mechanisms and Pathways.
Cudrania tricuspidata water extract improved obesity-induced hepatic insulin resistance in db/db mice by suppressing ER stress and inflammation.
Endoplasmic reticulum stress impairs insulin receptor signaling in the brains of obese rats.
Liver inflammation and metabolic signaling in ApcMin/+ mice: the role of cachexia progression.
Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice.
Imaging of single cell responses to ER stress indicates that the relative dynamics of IRE1/XBP1 and PERK/ATF4 signalling rather than a switch between signalling branches determine cell survival.
PERK/CHOP contributes to the CGK733-induced vesicular calcium sequestration which is accompanied by non-apoptotic cell death.
Fyn Activation of mTORC1 Stimulates the IRE1α-JNK Pathway, Leading to Cell Death.
Altered Oligodendrocyte Maturation and Myelin Maintenance: The Role of Antiretrovirals in HIV-Associated Neurocognitive Disorders.
Correlation of ER stress and retinal degeneration in tubby mice.
Endoplasmic reticulum stress-mediated apoptotic pathway is involved in corpus luteum regression in rats.
HIV infection and antiretroviral therapy lead to unfolded protein response activation.
Lipid-induced NOX2 activation inhibits autophagic flux by impairing lysosomal enzyme activity.
Regulation of glutamine carrier proteins by RNF5 determines breast cancer response to ER stress-inducing chemotherapies.
HIF2α-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma.
Acute Lung Injury Results from Innate Sensing of Viruses by an ER Stress Pathway.
The switch from ER stress-induced apoptosis to autophagy via ROS-mediated JNK/p62 signals: A survival mechanism in methotrexate-resistant choriocarcinoma cells.
Pressure Overload-Induced Cardiac Dysfunction in Aged Male Adiponectin Knockout Mice Is Associated With Autophagy Deficiency.
An ATF4-Signal-Modulating Machine Other Than GADD34 Acts in ATF4-to-CHOP Signaling to Block CHOP Expression in ER-Stress-Related Autophagy.
Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation.
Hyperglycemia-induced GLP-1R downregulation causes RPE cell apoptosis.
Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis.
Long-Range Inhibitor-Induced Conformational Regulation of Human IRE1α Endoribonuclease Activity.
Differential activation of ER stress pathways in myelinating cerebellar tracts.
Lack of phosphatidylethanolamine N-methyltransferase alters hepatic phospholipid composition and induces endoplasmic reticulum stress.
Melatonin inhibits tunicamycin-induced endoplasmic reticulum stress and insulin resistance in skeletal muscle cells.
Acetylcholine ameliorates endoplasmic reticulum stress in endothelial cells after hypoxia/reoxygenation via M3 AChR-AMPK signaling.
cGMP/Protein Kinase G Signaling Suppresses Inositol 1,4,5-Trisphosphate Receptor Phosphorylation and Promotes Endoplasmic Reticulum Stress in Photoreceptors of Cyclic Nucleotide-gated Channel-deficient Mice.
GSK-3β-dependent downregulation of γ-taxilin and αNAC merge to regulate ER stress responses.
Impairment of visual function and retinal ER stress activation in Wfs1-deficient mice.
Endoplasmic reticulum stress and unfolded protein response are involved in paediatric inflammatory bowel disease.
Reductive detoxification of acrolein as a potential role for aldehyde reductase (AKR1A) in mammals.
Glucosamine-induced Sp1 O-GlcNAcylation ameliorates hypoxia-induced SGLT dysfunction in primary cultured renal proximal tubule cells.
Ubiquitination of inositol-requiring enzyme 1 (IRE1) by the E3 ligase CHIP mediates the IRE1/TRAF2/JNK pathway.
Deficiency of osteoblastic Arl6ip5 impaired osteoblast differentiation and enhanced osteoclastogenesis via disturbance of ER calcium homeostasis and induction of ER stress-mediated apoptosis.
Granulovacuolar degeneration and unfolded protein response in mouse models of tauopathy and Aβ amyloidosis.
Reduction of endoplasmic reticulum stress inhibits neointima formation after vascular injury.
Transcription elongation factor ELL2 drives Ig secretory-specific mRNA production and the unfolded protein response.
HKH40A downregulates GRP78/BiP expression in cancer cells.
TERT attenuated ER stress-induced cell death.
The resveratrol attenuates ethanol-induced hepatocyte apoptosis via inhibiting ER-related caspase-12 activation and PDE activity in vitro.
Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARα axis signalling.
Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic β cells.
Endoplasmic reticulum stress plays critical role in brain damage after chronic intermittent hypoxia in growing rats.
Continual exposure to cigarette smoke extracts induces tumor-like transformation of human nontumor bronchial epithelial cells in a microfluidic chip.
Cytomegalovirus downregulates IRE1 to repress the unfolded protein response.
Differential responses of hepatic endoplasmic reticulum stress and inflammation in diet-induced obese rats with high-fat diet rich in lard oil or soybean oil.
Triglyceride-rich lipoprotein modulates endothelial vascular cell adhesion molecule (VCAM)-1 expression via differential regulation of endoplasmic reticulum stress.
KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance.
Tribbles 3 mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle.
PPM1l encodes an inositol requiring-protein 1 (IRE1) specific phosphatase that regulates the functional outcome of the ER stress response.
Selection of autophagy or apoptosis in cells exposed to ER-stress depends on ATF4 expression pattern with or without CHOP expression.
Membrane lipid saturation activates IRE1α without inducing clustering.
Inhibition of x-box binding protein 1 reduces tunicamycin-induced apoptosis in aged murine macrophages.
Endoplasmic reticulum stress signaling involvement in manganese-induced nerve cell damage in organotypic brain slice cultures.
ER stress in rodent islets of Langerhans is concomitant with obesity and β-cell compensation but not with β-cell dysfunction and diabetes.
Rutaecarpine analogues reduce lipid accumulation in adipocytes via inhibiting adipogenesis/lipogenesis with AMPK activation and UPR suppression.
The serine-threonine kinase inositol-requiring enzyme 1α (IRE1α) promotes IL-4 production in T helper cells.
Paneth cells as a site of origin for intestinal inflammation.
Proteasome dysfunction mediates obesity-induced endoplasmic reticulum stress and insulin resistance in the liver.
Curcumin induces apoptotic cell death of activated human CD4+ T cells via increasing endoplasmic reticulum stress and mitochondrial dysfunction.
RNF13, a RING finger protein, mediates endoplasmic reticulum stress-induced apoptosis through the inositol-requiring enzyme (IRE1α)/c-Jun NH2-terminal kinase pathway.
X-box binding protein 1 is essential for insulin regulation of pancreatic α-cell function.
The ER stress-mediated decrease in DDAH1 expression is involved in formaldehyde-induced apoptosis in lung epithelial cells.
Pathological endoplasmic reticulum stress mediated by the IRE1 pathway contributes to pre-insulitic beta cell apoptosis in a virus-induced rat model of type 1 diabetes.
Hepatic extracellular signal-regulated kinase 2 suppresses endoplasmic reticulum stress and protects from oxidative stress and endothelial dysfunction.
The unfolded protein response to endoplasmic reticulum stress in cultured astrocytes and rat brain during experimental diabetes.
ER stress signalling through eIF2α and CHOP, but not IRE1α, attenuates adipogenesis in mice.
Vitiligo-inducing phenols activate the unfolded protein response in melanocytes resulting in upregulation of IL6 and IL8.
Cleaved cytokeratin-18 is a mechanistically informative biomarker in idiopathic pulmonary fibrosis.
Insulin and insulin-like growth factor II differentially regulate endocytic sorting and stability of insulin receptor isoform A.
Sensing endoplasmic reticulum stress by protein kinase RNA-like endoplasmic reticulum kinase promotes adaptive mitochondrial DNA biogenesis and cell survival via heme oxygenase-1/carbon monoxide activity.
Acute hypoxia induces apoptosis of pancreatic β-cell by activation of the unfolded protein response and upregulation of CHOP.
Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing.
Synergistic effects of nelfinavir and bortezomib on proteotoxic death of NSCLC and multiple myeloma cells.
Endoplasmic reticulum stress inhibits STAT3-dependent suppression of hepatic gluconeogenesis via dephosphorylation and deacetylation.
Endoplasmic reticulum stress does not mediate palmitate-induced insulin resistance in mouse and human muscle cells.
Decreased expression of endoplasmic reticulum chaperone GRP78 in liver of diabetic mice.
Cdc37/Hsp90 protein-mediated regulation of IRE1α protein activity in endoplasmic reticulum stress response and insulin synthesis in INS-1 cells.
Autophagy plays a protective role in endoplasmic reticulum stress-mediated pancreatic β cell death.
Involvement of X-box binding protein 1 and reactive oxygen species pathways in the pathogenesis of tumour necrosis factor receptor-associated periodic syndrome.
Endoplasmic reticulum (ER) stress in cumulus-oocyte complexes impairs pentraxin-3 secretion, mitochondrial membrane potential (DeltaPsi m), and embryo development.
The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies.
Inhibition of enterovirus 71 entry by transcription factor XBP1.
Pancreatic β-cells depend on basal expression of active ATF6α-p50 for cell survival even under nonstress conditions.
HCV causes chronic endoplasmic reticulum stress leading to adaptation and interference with the unfolded protein response.
Accumulation of wildtype and ALS-linked mutated VAPB impairs activity of the proteasome.
Compromising the unfolded protein response induces autophagy-mediated cell death in multiple myeloma cells.
Measuring ER stress and the unfolded protein response using mammalian tissue culture system.
Measurement of ER stress response and inflammation in the mouse model of nonalcoholic fatty liver disease.
Endoplasmic reticulum stress implicated in the development of renal fibrosis.
BAX inhibitor-1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response.
Resveratrol triggers the pro-apoptotic endoplasmic reticulum stress response and represses pro-survival XBP1 signaling in human multiple myeloma cells.
Inhibition of the unfolded protein response by ricin a-chain enhances its cytotoxicity in mammalian cells.
Cannabidiol causes activated hepatic stellate cell death through a mechanism of endoplasmic reticulum stress-induced apoptosis.
Endoplasmic reticulum stress induces autophagy through activation of p38 MAPK in fibroblasts from Pompe disease patients carrying c.546G>T mutation.
Magnolol down-regulates HER2 gene expression, leading to inhibition of HER2-mediated metastatic potential in ovarian cancer cells.
Overexpression of Insig-1 protects β cell against glucolipotoxicity via SREBP-1c.
Involvement of endoplasmic reticulum stress defined by activated unfolded protein response in multiple system atrophy.
Circadian clock-coordinated 12 Hr period rhythmic activation of the IRE1alpha pathway controls lipid metabolism in mouse liver.
A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells.
AAV-mediated expression of wild-type and ALS-linked mutant VAPB selectively triggers death of motoneurons through a Ca2+-dependent ER-associated pathway.
A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response.
Astragalus polysaccharides decreased the expression of PTP1B through relieving ER stress induced activation of ATF6 in a rat model of type 2 diabetes.
The unfolded protein response is activated in pretangle neurons in Alzheimer's disease hippocampus.
Down-regulation of inhibition of differentiation-1 via activation of activating transcription factor 3 and Smad regulates REIC/Dickkopf-3-induced apoptosis.
AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress response.
Serine 129 phosphorylation of alpha-synuclein induces unfolded protein response-mediated cell death.
Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1.
Bellini L, Strub T, Habel N, Pandiani C, Marchetti S, Martel A, Baillif S, Bailly-Maitre B, Gual P, Ballotti R, Bertolotto C
Cell death discovery 2020;6:22
Cell death discovery 2020;6:22
Sodium tanshinone IIA sulfonate protects against Aβ1-42-induced cellular toxicity by modulating Aβ-degrading enzymes in HT22 cells.
Liu XQ, Deng YX, Dai Z, Hu T, Cai WW, Liu HF, Li H, Zhu WL, Li BY, Wang Q, Zhang SJ
International journal of biological macromolecules 2020 May 15;151:47-55
International journal of biological macromolecules 2020 May 15;151:47-55
Molecular changes in hepatic metabolism in ZDSD rats-A new polygenic rodent model of obesity, metabolic syndrome, and diabetes.
Han L, Bittner S, Dong D, Cortez Y, Bittner A, Chan J, Umar M, Shen WJ, Peterson RG, Kraemer FB, Azhar S
Biochimica et biophysica acta. Molecular basis of disease 2020 May 1;1866(5):165688
Biochimica et biophysica acta. Molecular basis of disease 2020 May 1;1866(5):165688
Effects of compound K, a metabolite of ginsenosides, on memory and cognitive dysfunction in db/db mice involve the inhibition of ER stress and the NLRP3 inflammasome pathway.
Li CW, Deng MZ, Gao ZJ, Dang YY, Zheng GD, Yang XJ, Chao YX, Cai YF, Wu XL
Food & function 2020 May 1;11(5):4416-4427
Food & function 2020 May 1;11(5):4416-4427
Interplay between Endoplasmic Reticulum (ER) Stress and Autophagy Induces Mutant p53H273 Degradation.
Garufi A, Federici G, Gilardini Montani MS, Crispini A, Cirone M, D'Orazi G
Biomolecules 2020 Mar 3;10(3)
Biomolecules 2020 Mar 3;10(3)
Paneth cell α-defensin misfolding correlates with dysbiosis and ileitis in Crohn's disease model mice.
Shimizu Y, Nakamura K, Yoshii A, Yokoi Y, Kikuchi M, Shinozaki R, Nakamura S, Ohira S, Sugimoto R, Ayabe T
Life science alliance 2020 Jun;3(6)
Life science alliance 2020 Jun;3(6)
Neferine alleviates memory and cognitive dysfunction in diabetic mice through modulation of the NLRP3 inflammasome pathway and alleviation of endoplasmic-reticulum stress.
Wu XL, Deng MZ, Gao ZJ, Dang YY, Li YC, Li CW
International immunopharmacology 2020 Jul;84:106559
International immunopharmacology 2020 Jul;84:106559
Activation of pH-Sensing Receptor OGR1 (GPR68) Induces ER Stress Via the IRE1α/JNK Pathway in an Intestinal Epithelial Cell Model.
Maeyashiki C, Melhem H, Hering L, Baebler K, Cosin-Roger J, Schefer F, Weder B, Hausmann M, Scharl M, Rogler G, de Vallière C, Ruiz PA
Scientific reports 2020 Jan 29;10(1):1438
Scientific reports 2020 Jan 29;10(1):1438
Calpain Activation Is the Major Cause of Cell Death in Photoreceptors Expressing a Rhodopsin Misfolding Mutation.
Comitato A, Schiroli D, Montanari M, Marigo V
Molecular neurobiology 2020 Feb;57(2):589-599
Molecular neurobiology 2020 Feb;57(2):589-599
Repression of viral gene expression and replication by the unfolded protein response effector XBP1u.
Hinte F, van Anken E, Tirosh B, Brune W
eLife 2020 Feb 17;9
eLife 2020 Feb 17;9
Intracellular proliferation of Anaplasma phagocytophilum is promoted via modulation of endoplasmic reticulum stress signaling in host cells.
Yoshikawa Y, Sugimoto K, Ochiai Y, Ohashi N
Microbiology and immunology 2020 Apr;64(4):270-279
Microbiology and immunology 2020 Apr;64(4):270-279
The unc-51 like autophagy activating kinase 1-autophagy related 13 complex has distinct functions in tunicamycin-treated cells.
Woo M, Choi HI, Park SH, Ahn J, Jang YJ, Ha TY, Lee DH, Seo HD, Jung CH
Biochemical and biophysical research communications 2020 Apr 9;524(3):744-749
Biochemical and biophysical research communications 2020 Apr 9;524(3):744-749
TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation.
Liu D, Zhang P, Zhou J, Liao R, Che Y, Gao MM, Sun J, Cai J, Cheng X, Huang Y, Chen G, Nie H, Ji YX, Zhang XJ, Huang Z, Xu H, She ZG, Li H
Cell metabolism 2020 Apr 7;31(4):726-740.e8
Cell metabolism 2020 Apr 7;31(4):726-740.e8
Disulfide bond-disrupting agents activate the tumor necrosis family-related apoptosis-inducing ligand/death receptor 5 pathway.
Wang M, Law ME, Davis BJ, Yaaghubi E, Ghilardi AF, Ferreira RB, Chiang CW, Guryanova OA, Kopinke D, Heldermon CD, Castellano RK, Law BK
Cell death discovery 2019;5:153
Cell death discovery 2019;5:153
The IRE1α Arm of UPR Regulates Muscle Cells Immune Characters by Restraining p38 MAPK Activation.
Gu R, Huang T, Xiao J, Liao Z, Li J, Lan H, Ouyang J, Hu J, Liao H
Frontiers in physiology 2019;10:1198
Frontiers in physiology 2019;10:1198
Hepatic nitric oxide synthase 1 adaptor protein regulates glucose homeostasis and hepatic insulin sensitivity in obese mice depending on its PDZ binding domain.
Mu K, Sun Y, Zhao Y, Zhao T, Li Q, Zhang M, Li H, Zhang R, Hu C, Wang C, Jia W
EBioMedicine 2019 Sep;47:352-364
EBioMedicine 2019 Sep;47:352-364
Hypoxic ER stress suppresses β-catenin expression and promotes cooperation between the transcription factors XBP1 and HIF1α for cell survival.
Xia Z, Wu S, Wei X, Liao Y, Yi P, Liu Y, Liu J, Liu J
The Journal of biological chemistry 2019 Sep 13;294(37):13811-13821
The Journal of biological chemistry 2019 Sep 13;294(37):13811-13821
Ebola virus-mediated T-lymphocyte depletion is the result of an abortive infection.
Younan P, Santos RI, Ramanathan P, Iampietro M, Nishida A, Dutta M, Ammosova T, Meyer M, Katze MG, Popov VL, Nekhai S, Bukreyev A
PLoS pathogens 2019 Oct;15(10):e1008068
PLoS pathogens 2019 Oct;15(10):e1008068
IRE1 promotes neurodegeneration through autophagy-dependent neuron death in the Drosophila model of Parkinson's disease.
Yan C, Liu J, Gao J, Sun Y, Zhang L, Song H, Xue L, Zhan L, Gao G, Ke Z, Liu Y, Liu J
Cell death & disease 2019 Oct 22;10(11):800
Cell death & disease 2019 Oct 22;10(11):800
Group VIA phospholipase A2 deficiency in mice chronically fed with high-fat-diet attenuates hepatic steatosis by correcting a defect of phospholipid remodeling.
Otto AC, Gan-Schreier H, Zhu X, Tuma-Kellner S, Staffer S, Ganzha A, Liebisch G, Chamulitrat W
Biochimica et biophysica acta. Molecular and cell biology of lipids 2019 May;1864(5):662-676
Biochimica et biophysica acta. Molecular and cell biology of lipids 2019 May;1864(5):662-676
ATG5 and ATG7 induced autophagy interplays with UPR via PERK signaling.
Zheng W, Xie W, Yin D, Luo R, Liu M, Guo F
Cell communication and signaling : CCS 2019 May 6;17(1):42
Cell communication and signaling : CCS 2019 May 6;17(1):42
Oxytocin Suppresses Inflammatory Responses Induced by Lipopolysaccharide through Inhibition of the eIF-2-ATF4 Pathway in Mouse Microglia.
Inoue T, Yamakage H, Tanaka M, Kusakabe T, Shimatsu A, Satoh-Asahara N
Cells 2019 May 31;8(6)
Cells 2019 May 31;8(6)
Bladder cancer extracellular vesicles drive tumorigenesis by inducing the unfolded protein response in endoplasmic reticulum of nonmalignant cells.
Wu CH, Silvers CR, Messing EM, Lee YF
The Journal of biological chemistry 2019 Mar 1;294(9):3207-3218
The Journal of biological chemistry 2019 Mar 1;294(9):3207-3218
Ameliorating Methylglyoxal-Induced Progenitor Cell Dysfunction for Tissue Repair in Diabetes.
Li H, O'Meara M, Zhang X, Zhang K, Seyoum B, Yi Z, Kaufman RJ, Monks TJ, Wang JM
Diabetes 2019 Jun;68(6):1287-1302
Diabetes 2019 Jun;68(6):1287-1302
PRKCSH contributes to tumorigenesis by selective boosting of IRE1 signaling pathway.
Shin GC, Moon SU, Kang HS, Choi HS, Han HD, Kim KH
Nature communications 2019 Jul 18;10(1):3185
Nature communications 2019 Jul 18;10(1):3185
Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation.
Wheeler MA, Jaronen M, Covacu R, Zandee SEJ, Scalisi G, Rothhammer V, Tjon EC, Chao CC, Kenison JE, Blain M, Rao VTS, Hewson P, Barroso A, Gutiérrez-Vázquez C, Prat A, Antel JP, Hauser R, Quintana FJ
Cell 2019 Jan 24;176(3):581-596.e18
Cell 2019 Jan 24;176(3):581-596.e18
ER-stress regulates macrophage polarization through pancreatic EIF-2alpha kinase.
Yang F, Liu Y, Ren H, Zhou G, Yuan X, Shi X
Cellular immunology 2019 Feb;336:40-47
Cellular immunology 2019 Feb;336:40-47
Granulovacuolar degeneration bodies are neuron-selective lysosomal structures induced by intracellular tau pathology.
Wiersma VI, van Ziel AM, Vazquez-Sanchez S, Nölle A, Berenjeno-Correa E, Bonaterra-Pastra A, Clavaguera F, Tolnay M, Musters RJP, van Weering JRT, Verhage M, Hoozemans JJM, Scheper W
Acta neuropathologica 2019 Dec;138(6):943-970
Acta neuropathologica 2019 Dec;138(6):943-970
Profile of the unfolded protein response in rat cerebellar cortical development.
Naughton M, McMahon J, Healy S, FitzGerald U
The Journal of comparative neurology 2019 Dec 1;527(17):2910-2924
The Journal of comparative neurology 2019 Dec 1;527(17):2910-2924
Prolonged high-fat-diet feeding promotes non-alcoholic fatty liver disease and alters gut microbiota in mice.
Velázquez KT, Enos RT, Bader JE, Sougiannis AT, Carson MS, Chatzistamou I, Carson JA, Nagarkatti PS, Nagarkatti M, Murphy EA
World journal of hepatology 2019 Aug 27;11(8):619-637
World journal of hepatology 2019 Aug 27;11(8):619-637
iPla2β Deficiency Suppresses Hepatic ER UPR, Fxr, and Phospholipids in Mice Fed with MCD Diet, Resulting in Exacerbated Hepatic Bile Acids and Biliary Cell Proliferation.
Ming Y, Zhu X, Tuma-Kellner S, Ganzha A, Liebisch G, Gan-Schreier H, Chamulitrat W
Cells 2019 Aug 12;8(8)
Cells 2019 Aug 12;8(8)
Nitrosative stress drives heart failure with preserved ejection fraction.
Schiattarella GG, Altamirano F, Tong D, French KM, Villalobos E, Kim SY, Luo X, Jiang N, May HI, Wang ZV, Hill TM, Mammen PPA, Huang J, Lee DI, Hahn VS, Sharma K, Kass DA, Lavandero S, Gillette TG, Hill JA
Nature 2019 Apr;568(7752):351-356
Nature 2019 Apr;568(7752):351-356
The Neuroprotection of Low-Dose Morphine in Cellular and Animal Models of Parkinson's Disease Through Ameliorating Endoplasmic Reticulum (ER) Stress and Activating Autophagy.
Wang B, Su CJ, Liu TT, Zhou Y, Feng Y, Huang Y, Liu X, Wang ZH, Chen LH, Luo WF, Liu T
Frontiers in molecular neuroscience 2018;11:120
Frontiers in molecular neuroscience 2018;11:120
Estrogen Receptor β Agonist Attenuates Endoplasmic Reticulum Stress-Induced Changes in Social Behavior and Brain Connectivity in Mice.
Crider A, Nelson T, Davis T, Fagan K, Vaibhav K, Luo M, Kamalasanan S, Terry AV Jr, Pillai A
Molecular neurobiology 2018 Sep;55(9):7606-7618
Molecular neurobiology 2018 Sep;55(9):7606-7618
Myristate-induced endoplasmic reticulum stress requires ceramide synthases 5/6 and generation of C14-ceramide in intestinal epithelial cells.
Choi S, Snider JM, Olakkengil N, Lambert JM, Anderson AK, Ross-Evans JS, Cowart LA, Snider AJ
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Oct;32(10):5724-5736
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Oct;32(10):5724-5736
Genome-wide analyses reveal the IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation.
Pramanik J, Chen X, Kar G, Henriksson J, Gomes T, Park JE, Natarajan K, Meyer KB, Miao Z, McKenzie ANJ, Mahata B, Teichmann SA
Genome medicine 2018 Oct 24;10(1):76
Genome medicine 2018 Oct 24;10(1):76
Heme scavenging reduces pulmonary endoplasmic reticulum stress, fibrosis, and emphysema.
Aggarwal S, Ahmad I, Lam A, Carlisle MA, Li C, Wells JM, Raju SV, Athar M, Rowe SM, Dransfield MT, Matalon S
JCI insight 2018 Nov 2;3(21)
JCI insight 2018 Nov 2;3(21)
Polysaccharide from Angelica sinensis protects H9c2 cells against oxidative injury and endoplasmic reticulum stress by activating the ATF6 pathway.
Niu X, Zhang J, Ling C, Bai M, Peng Y, Sun S, Li Y, Zhang Z
The Journal of international medical research 2018 May;46(5):1717-1733
The Journal of international medical research 2018 May;46(5):1717-1733
Endoplasmic Reticulum Chaperone GRP78 Protects Heart From Ischemia/Reperfusion Injury Through Akt Activation.
Bi X, Zhang G, Wang X, Nguyen C, May HI, Li X, Al-Hashimi AA, Austin RC, Gillette TG, Fu G, Wang ZV, Hill JA
Circulation research 2018 May 25;122(11):1545-1554
Circulation research 2018 May 25;122(11):1545-1554
Curcumin induces endoplasmic reticulum stress-associated apoptosis in human papillary thyroid carcinoma BCPAP cells via disruption of intracellular calcium homeostasis.
Zhang L, Cheng X, Xu S, Bao J, Yu H
Medicine 2018 Jun;97(24):e11095
Medicine 2018 Jun;97(24):e11095
The serine/threonine-protein kinase/endoribonuclease IRE1α protects the heart against pressure overload-induced heart failure.
Steiger D, Yokota T, Li J, Ren S, Minamisawa S, Wang Y
The Journal of biological chemistry 2018 Jun 22;293(25):9652-9661
The Journal of biological chemistry 2018 Jun 22;293(25):9652-9661
Designing an effective drug combination for ER stress loading in cancer therapy using a real-time monitoring system.
Kazama H, Hiramoto M, Miyahara K, Takano N, Miyazawa K
Biochemical and biophysical research communications 2018 Jun 18;501(1):286-292
Biochemical and biophysical research communications 2018 Jun 18;501(1):286-292
The three branches of the unfolded protein response exhibit differential significance in breast cancer growth and stemness.
Li C, Fan Q, Quan H, Nie M, Luo Y, Wang L
Experimental cell research 2018 Jun 15;367(2):170-185
Experimental cell research 2018 Jun 15;367(2):170-185
Farnesoid X receptor signaling activates the hepatic X-box binding protein 1 pathway in vitro and in mice.
Liu X, Guo GL, Kong B, Hilburn DB, Hubchak SC, Park S, LeCuyer B, Hsieh A, Wang L, Fang D, Green RM
Hepatology (Baltimore, Md.) 2018 Jul;68(1):304-316
Hepatology (Baltimore, Md.) 2018 Jul;68(1):304-316
Exosomal secretion of α-synuclein as protective mechanism after upstream blockage of macroautophagy.
Fussi N, Höllerhage M, Chakroun T, Nykänen NP, Rösler TW, Koeglsperger T, Wurst W, Behrends C, Höglinger GU
Cell death & disease 2018 Jul 9;9(7):757
Cell death & disease 2018 Jul 9;9(7):757
Pharmacological stimulation of p53 with low-dose doxorubicin ameliorates diet-induced nonalcoholic steatosis and steatohepatitis.
Porteiro B, Fondevila MF, Buque X, Gonzalez-Rellan MJ, Fernandez U, Mora A, Beiroa D, Senra A, Gallego R, Fernø J, López M, Sabio G, Dieguez C, Aspichueta P, Nogueiras R
Molecular metabolism 2018 Feb;8:132-143
Molecular metabolism 2018 Feb;8:132-143
Hepatic alcohol dehydrogenase deficiency induces pancreatic injury in chronic ethanol feeding model of deer mice.
Amer SM, Bhopale KK, Kakumanu RD, Popov VL, Rampy BA, El-Mehallawi IH, Ashmawy MM, Shakeel Ansari GA, Kaphalia BS
Experimental and molecular pathology 2018 Feb;104(1):89-97
Experimental and molecular pathology 2018 Feb;104(1):89-97
Inhibition of endoplasmic reticulum stress in high-fat-diet-induced obese C57BL/6 mice: Efficacy of a novel extract from mulberry (Morus alba) leaves fermented with Cordyceps militaris.
Lee MR, Bae SJ, Kim JE, Song BR, Choi JY, Park JJ, Park JW, Kang MJ, Choi HJ, Choi YW, Kim KM, Hwang DY
Laboratory animal research 2018 Dec;34(4):288-294
Laboratory animal research 2018 Dec;34(4):288-294
TMED2 Potentiates Cellular IFN Responses to DNA Viruses by Reinforcing MITA Dimerization and Facilitating Its Trafficking.
Sun MS, Zhang J, Jiang LQ, Pan YX, Tan JY, Yu F, Guo L, Yin L, Shen C, Shu HB, Liu Y
Cell reports 2018 Dec 11;25(11):3086-3098.e3
Cell reports 2018 Dec 11;25(11):3086-3098.e3
IRE1α aggravates ischemia reperfusion injury of fatty liver by regulating phenotypic transformation of kupffer cells.
Yang F, Wang S, Liu Y, Zhou Y, Shang L, Feng M, Yuan X, Zhu W, Shi X
Free radical biology & medicine 2018 Aug 20;124:395-407
Free radical biology & medicine 2018 Aug 20;124:395-407
Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate.
Chang TK, Lawrence DA, Lu M, Tan J, Harnoss JM, Marsters SA, Liu P, Sandoval W, Martin SE, Ashkenazi A
Molecular cell 2018 Aug 16;71(4):629-636.e5
Molecular cell 2018 Aug 16;71(4):629-636.e5
The IRE1α-XBP1s pathway promotes insulin-stimulated glucose uptake in adipocytes by increasing PPARγ activity.
Cho YM, Kim DH, Lee KH, Jeong SW, Kwon OJ
Experimental & molecular medicine 2018 Aug 15;50(8):102
Experimental & molecular medicine 2018 Aug 15;50(8):102
C-X-C Motif Chemokine 10 Impairs Autophagy and Autolysosome Formation in Non-alcoholic Steatohepatitis.
Zhang X, Wu WK, Xu W, Man K, Wang X, Han J, Leung WY, Wu R, Liu K, Yu J
Theranostics 2017;7(11):2822-2836
Theranostics 2017;7(11):2822-2836
Point mutation in D8C domain of Tamm-Horsfall protein/uromodulin in transgenic mice causes progressive renal damage and hyperuricemia.
Ma L, Liu Y, Landry NK, El-Achkar TM, Lieske JC, Wu XR
PloS one 2017;12(11):e0186769
PloS one 2017;12(11):e0186769
IRE1 signaling exacerbates Alzheimer's disease pathogenesis.
Duran-Aniotz C, Cornejo VH, Espinoza S, Ardiles ÁO, Medinas DB, Salazar C, Foley A, Gajardo I, Thielen P, Iwawaki T, Scheper W, Soto C, Palacios AG, Hoozemans JJM, Hetz C
Acta neuropathologica 2017 Sep;134(3):489-506
Acta neuropathologica 2017 Sep;134(3):489-506
The combination of digoxin and GSK2606414 exerts synergistic anticancer activity against leukemia in vitro and in vivo.
Zhang XH, Wang XY, Zhou ZW, Bai H, Shi L, Yang YX, Zhou SF, Zhang XC
BioFactors (Oxford, England) 2017 Nov;43(6):812-820
BioFactors (Oxford, England) 2017 Nov;43(6):812-820
Sodium 4-Phenylbutyrate Attenuates Myocardial Reperfusion Injury by Reducing the Unfolded Protein Response.
Takatori O, Usui S, Okajima M, Kaneko S, Ootsuji H, Takashima SI, Kobayashi D, Murai H, Furusho H, Takamura M
Journal of cardiovascular pharmacology and therapeutics 2017 May;22(3):283-292
Journal of cardiovascular pharmacology and therapeutics 2017 May;22(3):283-292
The metabolic ER stress sensor IRE1α suppresses alternative activation of macrophages and impairs energy expenditure in obesity.
Shan B, Wang X, Wu Y, Xu C, Xia Z, Dai J, Shao M, Zhao F, He S, Yang L, Zhang M, Nan F, Li J, Liu J, Liu J, Jia W, Qiu Y, Song B, Han JJ, Rui L, Duan SZ, Liu Y
Nature immunology 2017 May;18(5):519-529
Nature immunology 2017 May;18(5):519-529
Calpain mobilizes Atg9/Bif-1 vesicles from Golgi stacks upon autophagy induction by thapsigargin.
Marcassa E, Raimondi M, Anwar T, Eskelinen EL, Myers MP, Triolo G, Schneider C, Demarchi F
Biology open 2017 May 15;6(5):551-562
Biology open 2017 May 15;6(5):551-562
Attenuation of endoplasmic reticulum stress by caffeine ameliorates hyperoxia-induced lung injury.
Teng RJ, Jing X, Michalkiewicz T, Afolayan AJ, Wu TJ, Konduri GG
American journal of physiology. Lung cellular and molecular physiology 2017 May 1;312(5):L586-L598
American journal of physiology. Lung cellular and molecular physiology 2017 May 1;312(5):L586-L598
α(7)β(1) Integrin regulation of gene transcription in skeletal muscle following an acute bout of eccentric exercise.
Mahmassani ZS, Son K, Pincu Y, Munroe M, Drnevich J, Chen J, Boppart MD
American journal of physiology. Cell physiology 2017 May 1;312(5):C638-C650
American journal of physiology. Cell physiology 2017 May 1;312(5):C638-C650
Astragaloside IV protects against podocyte injury via SERCA2-dependent ER stress reduction and AMPKα-regulated autophagy induction in streptozotocin-induced diabetic nephropathy.
Guo H, Wang Y, Zhang X, Zang Y, Zhang Y, Wang L, Wang H, Wang Y, Cao A, Peng W
Scientific reports 2017 Jul 31;7(1):6852
Scientific reports 2017 Jul 31;7(1):6852
The constitutive lipid droplet protein PLIN2 regulates autophagy in liver.
Tsai TH, Chen E, Li L, Saha P, Lee HJ, Huang LS, Shelness GS, Chan L, Chang BH
Autophagy 2017 Jul 3;13(7):1130-1144
Autophagy 2017 Jul 3;13(7):1130-1144
Activation of TGF-β signaling induces cell death via the unfolded protein response in Fuchs endothelial corneal dystrophy.
Okumura N, Hashimoto K, Kitahara M, Okuda H, Ueda E, Watanabe K, Nakahara M, Sato T, Kinoshita S, Tourtas T, Schlötzer-Schrehardt U, Kruse F, Koizumi N
Scientific reports 2017 Jul 28;7(1):6801
Scientific reports 2017 Jul 28;7(1):6801
Burn-induced muscle metabolic derangements and mitochondrial dysfunction are associated with activation of HIF-1α and mTORC1: Role of protein farnesylation.
Nakazawa H, Ikeda K, Shinozaki S, Kobayashi M, Ikegami Y, Fu M, Nakamura T, Yasuhara S, Yu YM, Martyn JAJ, Tompkins RG, Shimokado K, Yorozu T, Ito H, Inoue S, Kaneki M
Scientific reports 2017 Jul 26;7(1):6618
Scientific reports 2017 Jul 26;7(1):6618
Sustained Activation of the Unfolded Protein Response Induces Cell Death in Fuchs' Endothelial Corneal Dystrophy.
Okumura N, Kitahara M, Okuda H, Hashimoto K, Ueda E, Nakahara M, Kinoshita S, Young RD, Quantock AJ, Tourtas T, Schlötzer-Schrehardt U, Kruse F, Koizumi N
Investigative ophthalmology & visual science 2017 Jul 1;58(9):3697-3707
Investigative ophthalmology & visual science 2017 Jul 1;58(9):3697-3707
A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1α stability.
Liu J, Wang Y, Song L, Zeng L, Yi W, Liu T, Chen H, Wang M, Ju Z, Cong YS
Nature communications 2017 Jan 27;8:14186
Nature communications 2017 Jan 27;8:14186
The specialized proresolving lipid mediator maresin 1 protects hepatocytes from lipotoxic and hypoxia-induced endoplasmic reticulum stress.
Rius B, Duran-Güell M, Flores-Costa R, López-Vicario C, Lopategi A, Alcaraz-Quiles J, Casulleras M, Lozano JJ, Titos E, Clària J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Dec;31(12):5384-5398
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Dec;31(12):5384-5398
Salubrinal protects human skin fibroblasts against UVB-induced cell death by blocking endoplasmic reticulum (ER) stress and regulating calcium homeostasis.
Ji C, Yang B, Huang SY, Huang JW, Cheng B
Biochemical and biophysical research communications 2017 Dec 2;493(4):1371-1376
Biochemical and biophysical research communications 2017 Dec 2;493(4):1371-1376
Ultrastructure and immunohistochemical characterization of proteins concerned with the secretory machinery in goat ceruminous glands.
Yasui T, Gomi H, Kitahara T, Tsukise A
European journal of histochemistry : EJH 2017 Aug 8;61(3):2828
European journal of histochemistry : EJH 2017 Aug 8;61(3):2828
Wfs1- deficient rats develop primary symptoms of Wolfram syndrome: insulin-dependent diabetes, optic nerve atrophy and medullary degeneration.
Plaas M, Seppa K, Reimets R, Jagomäe T, Toots M, Koppel T, Vallisoo T, Nigul M, Heinla I, Meier R, Kaasik A, Piirsoo A, Hickey MA, Terasmaa A, Vasar E
Scientific reports 2017 Aug 31;7(1):10220
Scientific reports 2017 Aug 31;7(1):10220
Sigmar1 regulates endoplasmic reticulum stress-induced C/EBP-homologous protein expression in cardiomyocytes.
Alam S, Abdullah CS, Aishwarya R, Orr AW, Traylor J, Miriyala S, Panchatcharam M, Pattillo CB, Bhuiyan MS
Bioscience reports 2017 Aug 31;37(4)
Bioscience reports 2017 Aug 31;37(4)
IER3IP1 deficiency leads to increased β-cell death and decreased β-cell proliferation.
Sun J, Ren D
Oncotarget 2017 Aug 22;8(34):56768-56779
Oncotarget 2017 Aug 22;8(34):56768-56779
Astragaloside IV Attenuates Podocyte Apoptosis Mediated by Endoplasmic Reticulum Stress through Upregulating Sarco/Endoplasmic Reticulum Ca2+-ATPase 2 Expression in Diabetic Nephropathy.
Guo H, Cao A, Chu S, Wang Y, Zang Y, Mao X, Wang H, Wang Y, Liu C, Zhang X, Peng W
Frontiers in pharmacology 2016;7:500
Frontiers in pharmacology 2016;7:500
Role of chemokine C-C motif ligand-1 in acute and chronic pulmonary inflammations.
Kishi H, Sato M, Shibata Y, Sato K, Inoue S, Abe S, Kimura T, Nishiwaki M, Yamauchi K, Nemoto T, Igarashi A, Tokairin Y, Nakajima O, Kubota I
SpringerPlus 2016;5(1):1241
SpringerPlus 2016;5(1):1241
Effects of a Sublethal and Transient Stress of the Endoplasmic Reticulum on the Mitochondrial Population.
Vannuvel K, Van Steenbrugge M, Demazy C, Ninane N, Fattaccioli A, Fransolet M, Renard P, Raes M, Arnould T
Journal of cellular physiology 2016 Sep;231(9):1913-31
Journal of cellular physiology 2016 Sep;231(9):1913-31
A super gene expression system enhances the anti-glioma effects of adenovirus-mediated REIC/Dkk-3 gene therapy.
Oka T, Kurozumi K, Shimazu Y, Ichikawa T, Ishida J, Otani Y, Shimizu T, Tomita Y, Sakaguchi M, Watanabe M, Nasu Y, Kumon H, Date I
Scientific reports 2016 Sep 14;6:33319
Scientific reports 2016 Sep 14;6:33319
Activation of the unfolded protein response and granulovacuolar degeneration are not common features of human prion pathology.
Wiersma VI, van Hecke W, Scheper W, van Osch MA, Hermsen WJ, Rozemuller AJ, Hoozemans JJ
Acta neuropathologica communications 2016 Oct 28;4(1):113
Acta neuropathologica communications 2016 Oct 28;4(1):113
MicroRNA-124 promotes hepatic triglyceride accumulation through targeting tribbles homolog 3.
Liu X, Zhao J, Liu Q, Xiong X, Zhang Z, Jiao Y, Li X, Liu B, Li Y, Lu Y
Scientific reports 2016 Nov 15;6:37170
Scientific reports 2016 Nov 15;6:37170
The small molecule '1-(4-biphenylylcarbonyl)-4-(5-bromo-2-methoxybenzyl) piperazine oxalate' and its derivatives regulate global protein synthesis by inactivating eukaryotic translation initiation factor 2-alpha.
Hong MN, Nam KY, Kim KK, Kim SY, Kim I
Cell stress & chaperones 2016 May;21(3):485-97
Cell stress & chaperones 2016 May;21(3):485-97
Global quantitative proteomics reveal up-regulation of endoplasmic reticulum stress response proteins upon depletion of eIF5A in HeLa cells.
Mandal A, Mandal S, Park MH
Scientific reports 2016 May 16;6:25795
Scientific reports 2016 May 16;6:25795
Vitamin C modulates the metabolic and cytokine profiles, alleviates hepatic endoplasmic reticulum stress, and increases the life span of Gulo-/- mice.
Aumailley L, Warren A, Garand C, Dubois MJ, Paquet ER, Le Couteur DG, Marette A, Cogger VC, Lebel M
Aging 2016 Mar;8(3):458-83
Aging 2016 Mar;8(3):458-83
Carnosic acid slows photoreceptor degeneration in the Pde6b(rd10) mouse model of retinitis pigmentosa.
Kang K, Tarchick MJ, Yu X, Beight C, Bu P, Yu M
Scientific reports 2016 Mar 10;6:22632
Scientific reports 2016 Mar 10;6:22632
Maternal obesity alters endoplasmic reticulum homeostasis in offspring pancreas.
Soeda J, Mouralidarane A, Cordero P, Li J, Nguyen V, Carter R, Kapur SR, Pombo J, Poston L, Taylor PD, Vinciguerra M, Oben JA
Journal of physiology and biochemistry 2016 Jun;72(2):281-91
Journal of physiology and biochemistry 2016 Jun;72(2):281-91
Carboxylesterase 2 prevents liver steatosis by modulating lipolysis, endoplasmic reticulum stress, and lipogenesis and is regulated by hepatocyte nuclear factor 4 alpha in mice.
Li Y, Zalzala M, Jadhav K, Xu Y, Kasumov T, Yin L, Zhang Y
Hepatology (Baltimore, Md.) 2016 Jun;63(6):1860-74
Hepatology (Baltimore, Md.) 2016 Jun;63(6):1860-74
Endoplasmic reticulum-associated degradation of the mouse PC1/3-N222D hypomorph and human PCSK1 mutations contributes to obesity.
Stijnen P, Brouwers B, Dirkx E, Ramos-Molina B, Van Lommel L, Schuit F, Thorrez L, Declercq J, Creemers JW
International journal of obesity (2005) 2016 Jun;40(6):973-81
International journal of obesity (2005) 2016 Jun;40(6):973-81
Asymmetric dimethylarginine (ADMA) treatment induces apoptosis in cultured rat mesangial cells via endoplasmic reticulum stress activation.
Park MJ, Oh KS, Nho JH, Kim GY, Kim DI
Cell biology international 2016 Jun;40(6):662-70
Cell biology international 2016 Jun;40(6):662-70
Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2α, IRE1α, ATF6 and calmodulin kinase.
Merlot AM, Shafie NH, Yu Y, Richardson V, Jansson PJ, Sahni S, Lane DJR, Kovacevic Z, Kalinowski DS, Richardson DR
Biochemical pharmacology 2016 Jun 1;109:27-47
Biochemical pharmacology 2016 Jun 1;109:27-47
IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation.
Takatani T, Shirakawa J, Roe MW, Leech CA, Maier BF, Mirmira RG, Kulkarni RN
Scientific reports 2016 Jul 5;6:28177
Scientific reports 2016 Jul 5;6:28177
Intravenous Lipid Infusion Induces Endoplasmic Reticulum Stress in Endothelial Cells and Blood Mononuclear Cells of Healthy Adults.
Tampakakis E, Tabit CE, Holbrook M, Linder EA, Berk BD, Frame AA, Bretón-Romero R, Fetterman JL, Gokce N, Vita JA, Hamburg NM
Journal of the American Heart Association 2016 Jan 11;5(1)
Journal of the American Heart Association 2016 Jan 11;5(1)
Limited Unfolded Protein Response and Inflammation in Neuroserpinopathy.
López-González I, Pérez-Mediavilla A, Zamarbide M, Carmona M, Torrejón Escribano B, Glatzel M, Galliciotti G, Ferrer I
Journal of neuropathology and experimental neurology 2016 Feb;75(2):121-33
Journal of neuropathology and experimental neurology 2016 Feb;75(2):121-33
Salidroside Protects Against 6-Hydroxydopamine-Induced Cytotoxicity by Attenuating ER Stress.
Tao K, Wang B, Feng D, Zhang W, Lu F, Lai J, Huang L, Nie T, Yang Q
Neuroscience bulletin 2016 Feb;32(1):61-9
Neuroscience bulletin 2016 Feb;32(1):61-9
Imiquimod-induced apoptosis of melanoma cells is mediated by ER stress-dependent Noxa induction and enhanced by NF-κB inhibition.
El-Khattouti A, Selimovic D, Hannig M, Taylor EB, Abd Elmageed ZY, Hassan SY, Haikel Y, Kandil E, Leverkus M, Brodell RT, Megahed M, Hassan M
Journal of cellular and molecular medicine 2016 Feb;20(2):266-86
Journal of cellular and molecular medicine 2016 Feb;20(2):266-86
Alkylating Agent-Induced NRF2 Blocks Endoplasmic Reticulum Stress-Mediated Apoptosis via Control of Glutathione Pools and Protein Thiol Homeostasis.
Zanotto-Filho A, Masamsetti VP, Loranc E, Tonapi SS, Gorthi A, Bernard X, Gonçalves RM, Moreira JC, Chen Y, Bishop AJ
Molecular cancer therapeutics 2016 Dec;15(12):3000-3014
Molecular cancer therapeutics 2016 Dec;15(12):3000-3014
VCP inhibitors induce endoplasmic reticulum stress, cause cell cycle arrest, trigger caspase-mediated cell death and synergistically kill ovarian cancer cells in combination with Salubrinal.
Bastola P, Neums L, Schoenen FJ, Chien J
Molecular oncology 2016 Dec;10(10):1559-1574
Molecular oncology 2016 Dec;10(10):1559-1574
Knockout of inositol-requiring enzyme 1α in pro-opiomelanocortin neurons decreases fat mass via increasing energy expenditure.
Xiao Y, Xia T, Yu J, Deng Y, Liu H, Liu B, Chen S, Liu Y, Guo F
Open biology 2016 Aug;6(8)
Open biology 2016 Aug;6(8)
β-Asarone Inhibits IRE1/XBP1 Endoplasmic Reticulum Stress Pathway in 6-OHDA-Induced Parkinsonian Rats.
Ning B, Deng M, Zhang Q, Wang N, Fang Y
Neurochemical research 2016 Aug;41(8):2097-101
Neurochemical research 2016 Aug;41(8):2097-101
Spontaneous nonalcoholic fatty liver disease and ER stress in Sidt2 deficiency mice.
Gao J, Zhang Y, Yu C, Tan F, Wang L
Biochemical and biophysical research communications 2016 Aug 5;476(4):326-332
Biochemical and biophysical research communications 2016 Aug 5;476(4):326-332
Ursodeoxycholic Acid Ameliorated Diabetic Nephropathy by Attenuating Hyperglycemia-Mediated Oxidative Stress.
Cao A, Wang L, Chen X, Guo H, Chu S, Zhang X, Peng W
Biological & pharmaceutical bulletin 2016 Aug 1;39(8):1300-8
Biological & pharmaceutical bulletin 2016 Aug 1;39(8):1300-8
Cytokines Regulate β-Cell Thioredoxin-interacting Protein (TXNIP) via Distinct Mechanisms and Pathways.
Hong K, Xu G, Grayson TB, Shalev A
The Journal of biological chemistry 2016 Apr 15;291(16):8428-39
The Journal of biological chemistry 2016 Apr 15;291(16):8428-39
Cudrania tricuspidata water extract improved obesity-induced hepatic insulin resistance in db/db mice by suppressing ER stress and inflammation.
Kim OK, Nam DE, Jun W, Lee J
Food & nutrition research 2015;59:29165
Food & nutrition research 2015;59:29165
Endoplasmic reticulum stress impairs insulin receptor signaling in the brains of obese rats.
Liang L, Chen J, Zhan L, Lu X, Sun X, Sui H, Zheng L, Xiang H, Zhang F
PloS one 2015;10(5):e0126384
PloS one 2015;10(5):e0126384
Liver inflammation and metabolic signaling in ApcMin/+ mice: the role of cachexia progression.
Narsale AA, Enos RT, Puppa MJ, Chatterjee S, Murphy EA, Fayad R, Pena MO, Durstine JL, Carson JA
PloS one 2015;10(3):e0119888
PloS one 2015;10(3):e0119888
Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice.
Aumailley L, Garand C, Dubois MJ, Johnson FB, Marette A, Lebel M
PloS one 2015;10(10):e0140292
PloS one 2015;10(10):e0140292
Imaging of single cell responses to ER stress indicates that the relative dynamics of IRE1/XBP1 and PERK/ATF4 signalling rather than a switch between signalling branches determine cell survival.
Walter F, Schmid J, Düssmann H, Concannon CG, Prehn JH
Cell death and differentiation 2015 Sep;22(9):1502-16
Cell death and differentiation 2015 Sep;22(9):1502-16
PERK/CHOP contributes to the CGK733-induced vesicular calcium sequestration which is accompanied by non-apoptotic cell death.
Wang Y, Kuramitsu Y, Baron B, Kitagawa T, Akada J, Tokuda K, Cui D, Nakamura K
Oncotarget 2015 Sep 22;6(28):25252-65
Oncotarget 2015 Sep 22;6(28):25252-65
Fyn Activation of mTORC1 Stimulates the IRE1α-JNK Pathway, Leading to Cell Death.
Wang Y, Yamada E, Zong H, Pessin JE
The Journal of biological chemistry 2015 Oct 9;290(41):24772-83
The Journal of biological chemistry 2015 Oct 9;290(41):24772-83
Altered Oligodendrocyte Maturation and Myelin Maintenance: The Role of Antiretrovirals in HIV-Associated Neurocognitive Disorders.
Jensen BK, Monnerie H, Mannell MV, Gannon PJ, Espinoza CA, Erickson MA, Bruce-Keller AJ, Gelman BB, Briand LA, Pierce RC, Jordan-Sciutto KL, Grinspan JB
Journal of neuropathology and experimental neurology 2015 Nov;74(11):1093-118
Journal of neuropathology and experimental neurology 2015 Nov;74(11):1093-118
Correlation of ER stress and retinal degeneration in tubby mice.
Cai X, Chen L, McGinnis JF
Experimental eye research 2015 Nov;140:130-138
Experimental eye research 2015 Nov;140:130-138
Endoplasmic reticulum stress-mediated apoptotic pathway is involved in corpus luteum regression in rats.
Yang Y, Sun M, Shan Y, Zheng X, Ma H, Ma W, Wang Z, Pei X, Wang Y
Reproductive sciences (Thousand Oaks, Calif.) 2015 May;22(5):572-84
Reproductive sciences (Thousand Oaks, Calif.) 2015 May;22(5):572-84
HIV infection and antiretroviral therapy lead to unfolded protein response activation.
Borsa M, Ferreira PL, Petry A, Ferreira LG, Camargo MM, Bou-Habib DC, Pinto AR
Virology journal 2015 May 15;12:77
Virology journal 2015 May 15;12:77
Lipid-induced NOX2 activation inhibits autophagic flux by impairing lysosomal enzyme activity.
Jaishy B, Zhang Q, Chung HS, Riehle C, Soto J, Jenkins S, Abel P, Cowart LA, Van Eyk JE, Abel ED
Journal of lipid research 2015 Mar;56(3):546-61
Journal of lipid research 2015 Mar;56(3):546-61
Regulation of glutamine carrier proteins by RNF5 determines breast cancer response to ER stress-inducing chemotherapies.
Jeon YJ, Khelifa S, Ratnikov B, Scott DA, Feng Y, Parisi F, Ruller C, Lau E, Kim H, Brill LM, Jiang T, Rimm DL, Cardiff RD, Mills GB, Smith JW, Osterman AL, Kluger Y, Ronai ZA
Cancer cell 2015 Mar 9;27(3):354-69
Cancer cell 2015 Mar 9;27(3):354-69
HIF2α-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma.
Qiu B, Ackerman D, Sanchez DJ, Li B, Ochocki JD, Grazioli A, Bobrovnikova-Marjon E, Diehl JA, Keith B, Simon MC
Cancer discovery 2015 Jun;5(6):652-67
Cancer discovery 2015 Jun;5(6):652-67
Acute Lung Injury Results from Innate Sensing of Viruses by an ER Stress Pathway.
Hrincius ER, Liedmann S, Finkelstein D, Vogel P, Gansebom S, Samarasinghe AE, You D, Cormier SA, McCullers JA
Cell reports 2015 Jun 16;11(10):1591-603
Cell reports 2015 Jun 16;11(10):1591-603
The switch from ER stress-induced apoptosis to autophagy via ROS-mediated JNK/p62 signals: A survival mechanism in methotrexate-resistant choriocarcinoma cells.
Shen Y, Yang J, Zhao J, Xiao C, Xu C, Xiang Y
Experimental cell research 2015 Jun 10;334(2):207-18
Experimental cell research 2015 Jun 10;334(2):207-18
Pressure Overload-Induced Cardiac Dysfunction in Aged Male Adiponectin Knockout Mice Is Associated With Autophagy Deficiency.
Jahng JW, Turdi S, Kovacevic V, Dadson K, Li RK, Sweeney G
Endocrinology 2015 Jul;156(7):2667-77
Endocrinology 2015 Jul;156(7):2667-77
An ATF4-Signal-Modulating Machine Other Than GADD34 Acts in ATF4-to-CHOP Signaling to Block CHOP Expression in ER-Stress-Related Autophagy.
Iwasaki N, Sugiyama Y, Miyazaki S, Nakagawa H, Nishimura K, Matsuo S
Journal of cellular biochemistry 2015 Jul;116(7):1300-9
Journal of cellular biochemistry 2015 Jul;116(7):1300-9
Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation.
Clarke JR, Lyra E Silva NM, Figueiredo CP, Frozza RL, Ledo JH, Beckman D, Katashima CK, Razolli D, Carvalho BM, Frazão R, Silveira MA, Ribeiro FC, Bomfim TR, Neves FS, Klein WL, Medeiros R, LaFerla FM, Carvalheira JB, Saad MJ, Munoz DP, Velloso LA, Ferreira ST, De Felice FG
EMBO molecular medicine 2015 Feb;7(2):190-210
EMBO molecular medicine 2015 Feb;7(2):190-210
Hyperglycemia-induced GLP-1R downregulation causes RPE cell apoptosis.
Kim DI, Park MJ, Choi JH, Lim SK, Choi HJ, Park SH
The international journal of biochemistry & cell biology 2015 Feb;59:41-51
The international journal of biochemistry & cell biology 2015 Feb;59:41-51
Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis.
Wu H, Wei L, Fan F, Ji S, Zhang S, Geng J, Hong L, Fan X, Chen Q, Tian J, Jiang M, Sun X, Jin C, Yin ZY, Liu Q, Zhang J, Qin F, Lin KH, Yu JS, Deng X, Wang HR, Zhao B, Johnson RL, Chen L, Zhou D
Nature communications 2015 Feb 19;6:6239
Nature communications 2015 Feb 19;6:6239
Long-Range Inhibitor-Induced Conformational Regulation of Human IRE1α Endoribonuclease Activity.
Concha NO, Smallwood A, Bonnette W, Totoritis R, Zhang G, Federowicz K, Yang J, Qi H, Chen S, Campobasso N, Choudhry AE, Shuster LE, Evans KA, Ralph J, Sweitzer S, Heerding DA, Buser CA, Su DS, DeYoung MP
Molecular pharmacology 2015 Dec;88(6):1011-23
Molecular pharmacology 2015 Dec;88(6):1011-23
Differential activation of ER stress pathways in myelinating cerebellar tracts.
Naughton MC, McMahon JM, FitzGerald U
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2015 Dec;47(Pt B):347-60
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2015 Dec;47(Pt B):347-60
Lack of phosphatidylethanolamine N-methyltransferase alters hepatic phospholipid composition and induces endoplasmic reticulum stress.
Gao X, van der Veen JN, Vance JE, Thiesen A, Vance DE, Jacobs RL
Biochimica et biophysica acta 2015 Dec;1852(12):2689-99
Biochimica et biophysica acta 2015 Dec;1852(12):2689-99
Melatonin inhibits tunicamycin-induced endoplasmic reticulum stress and insulin resistance in skeletal muscle cells.
Quan X, Wang J, Liang C, Zheng H, Zhang L
Biochemical and biophysical research communications 2015 Aug 7;463(4):1102-7
Biochemical and biophysical research communications 2015 Aug 7;463(4):1102-7
Acetylcholine ameliorates endoplasmic reticulum stress in endothelial cells after hypoxia/reoxygenation via M3 AChR-AMPK signaling.
Bi X, He X, Xu M, Zhao M, Yu X, Lu X, Zang W
Cell cycle (Georgetown, Tex.) 2015 Aug 3;14(15):2461-72
Cell cycle (Georgetown, Tex.) 2015 Aug 3;14(15):2461-72
cGMP/Protein Kinase G Signaling Suppresses Inositol 1,4,5-Trisphosphate Receptor Phosphorylation and Promotes Endoplasmic Reticulum Stress in Photoreceptors of Cyclic Nucleotide-gated Channel-deficient Mice.
Ma H, Butler MR, Thapa A, Belcher J, Yang F, Baehr W, Biel M, Michalakis S, Ding XQ
The Journal of biological chemistry 2015 Aug 21;290(34):20880-92
The Journal of biological chemistry 2015 Aug 21;290(34):20880-92
GSK-3β-dependent downregulation of γ-taxilin and αNAC merge to regulate ER stress responses.
Hotokezaka Y, Katayama I, van Leyen K, Nakamura T
Cell death & disease 2015 Apr 16;6(4):e1719
Cell death & disease 2015 Apr 16;6(4):e1719
Impairment of visual function and retinal ER stress activation in Wfs1-deficient mice.
Bonnet Wersinger D, Benkafadar N, Jagodzinska J, Hamel C, Tanizawa Y, Lenaers G, Delettre C
PloS one 2014;9(5):e97222
PloS one 2014;9(5):e97222
Endoplasmic reticulum stress and unfolded protein response are involved in paediatric inflammatory bowel disease.
Negroni A, Prete E, Vitali R, Cesi V, Aloi M, Civitelli F, Cucchiara S, Stronati L
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2014 Sep;46(9):788-94
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2014 Sep;46(9):788-94
Reductive detoxification of acrolein as a potential role for aldehyde reductase (AKR1A) in mammals.
Kurahashi T, Kwon M, Homma T, Saito Y, Lee J, Takahashi M, Yamada K, Miyata S, Fujii J
Biochemical and biophysical research communications 2014 Sep 12;452(1):136-41
Biochemical and biophysical research communications 2014 Sep 12;452(1):136-41
Glucosamine-induced Sp1 O-GlcNAcylation ameliorates hypoxia-induced SGLT dysfunction in primary cultured renal proximal tubule cells.
Suh HN, Lee YJ, Kim MO, Ryu JM, Han HJ
Journal of cellular physiology 2014 Oct;229(10):1557-68
Journal of cellular physiology 2014 Oct;229(10):1557-68
Ubiquitination of inositol-requiring enzyme 1 (IRE1) by the E3 ligase CHIP mediates the IRE1/TRAF2/JNK pathway.
Zhu X, Zhang J, Sun H, Jiang C, Dong Y, Shan Q, Su S, Xie Y, Xu N, Lou X, Liu S
The Journal of biological chemistry 2014 Oct 31;289(44):30567-30577
The Journal of biological chemistry 2014 Oct 31;289(44):30567-30577
Deficiency of osteoblastic Arl6ip5 impaired osteoblast differentiation and enhanced osteoclastogenesis via disturbance of ER calcium homeostasis and induction of ER stress-mediated apoptosis.
Wu Y, Yang M, Fan J, Peng Y, Deng L, Ding Y, Yang R, Zhou J, Miao D, Fu Q
Cell death & disease 2014 Oct 16;5:e1464
Cell death & disease 2014 Oct 16;5:e1464
Granulovacuolar degeneration and unfolded protein response in mouse models of tauopathy and Aβ amyloidosis.
Köhler C, Dinekov M, Götz J
Neurobiology of disease 2014 Nov;71:169-79
Neurobiology of disease 2014 Nov;71:169-79
Reduction of endoplasmic reticulum stress inhibits neointima formation after vascular injury.
Ishimura S, Furuhashi M, Mita T, Fuseya T, Watanabe Y, Hoshina K, Kokubu N, Inoue K, Yoshida H, Miura T
Scientific reports 2014 Nov 6;4:6943
Scientific reports 2014 Nov 6;4:6943
Transcription elongation factor ELL2 drives Ig secretory-specific mRNA production and the unfolded protein response.
Park KS, Bayles I, Szlachta-McGinn A, Paul J, Boiko J, Santos P, Liu J, Wang Z, Borghesi L, Milcarek C
Journal of immunology (Baltimore, Md. : 1950) 2014 Nov 1;193(9):4663-74
Journal of immunology (Baltimore, Md. : 1950) 2014 Nov 1;193(9):4663-74
HKH40A downregulates GRP78/BiP expression in cancer cells.
Kosakowska-Cholody T, Lin J, Srideshikan SM, Scheffer L, Tarasova NI, Acharya JK
Cell death & disease 2014 May 22;5:e1240
Cell death & disease 2014 May 22;5:e1240
TERT attenuated ER stress-induced cell death.
Hosoi T, Inoue Y, Nakatsu K, Matsushima N, Kiyose N, Shimamoto A, Tahara H, Ozawa K
Biochemical and biophysical research communications 2014 May 2;447(2):378-82
Biochemical and biophysical research communications 2014 May 2;447(2):378-82
The resveratrol attenuates ethanol-induced hepatocyte apoptosis via inhibiting ER-related caspase-12 activation and PDE activity in vitro.
Liu LQ, Fan ZQ, Tang YF, Ke ZJ
Alcoholism, clinical and experimental research 2014 Mar;38(3):683-93
Alcoholism, clinical and experimental research 2014 Mar;38(3):683-93
Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARα axis signalling.
Shao M, Shan B, Liu Y, Deng Y, Yan C, Wu Y, Mao T, Qiu Y, Zhou Y, Jiang S, Jia W, Li J, Li J, Rui L, Yang L, Liu Y
Nature communications 2014 Mar 27;5:3528
Nature communications 2014 Mar 27;5:3528
Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic β cells.
Liew CW, Assmann A, Templin AT, Raum JC, Lipson KL, Rajan S, Qiang G, Hu J, Kawamori D, Lindberg I, Philipson LH, Sonenberg N, Goldfine AB, Stoffers DA, Mirmira RG, Urano F, Kulkarni RN
Proceedings of the National Academy of Sciences of the United States of America 2014 Jun 3;111(22):E2319-28
Proceedings of the National Academy of Sciences of the United States of America 2014 Jun 3;111(22):E2319-28
Endoplasmic reticulum stress plays critical role in brain damage after chronic intermittent hypoxia in growing rats.
Cai XH, Li XC, Jin SW, Liang DS, Wen ZW, Cao HC, Mei HF, Wu Y, Lin ZD, Wang LX
Experimental neurology 2014 Jul;257:148-56
Experimental neurology 2014 Jul;257:148-56
Continual exposure to cigarette smoke extracts induces tumor-like transformation of human nontumor bronchial epithelial cells in a microfluidic chip.
Li E, Xu Z, Liu F, Wang H, Wen J, Shao S, Zhang L, Wang L, Liu C, Lu J, Wang W, Gao Z, Wang Q
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2014 Aug;9(8):1091-100
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2014 Aug;9(8):1091-100
Cytomegalovirus downregulates IRE1 to repress the unfolded protein response.
Stahl S, Burkhart JM, Hinte F, Tirosh B, Mohr H, Zahedi RP, Sickmann A, Ruzsics Z, Budt M, Brune W
PLoS pathogens 2013;9(8):e1003544
PLoS pathogens 2013;9(8):e1003544
Differential responses of hepatic endoplasmic reticulum stress and inflammation in diet-induced obese rats with high-fat diet rich in lard oil or soybean oil.
Zhao M, Zang B, Cheng M, Ma Y, Yang Y, Yang N
PloS one 2013;8(11):e78620
PloS one 2013;8(11):e78620
Triglyceride-rich lipoprotein modulates endothelial vascular cell adhesion molecule (VCAM)-1 expression via differential regulation of endoplasmic reticulum stress.
Wang YI, Bettaieb A, Sun C, DeVerse JS, Radecke CE, Mathew S, Edwards CM, Haj FG, Passerini AG, Simon SI
PloS one 2013;8(10):e78322
PloS one 2013;8(10):e78322
KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance.
Jung DY, Chalasani U, Pan N, Friedline RH, Prosdocimo DA, Nam M, Azuma Y, Maganti R, Yu K, Velagapudi A, O'Sullivan-Murphy B, Sartoretto JL, Jain MK, Cooper MP, Urano F, Kim JK, Gray S
PloS one 2013;8(10):e77851
PloS one 2013;8(10):e77851
Tribbles 3 mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle.
Koh HJ, Toyoda T, Didesch MM, Lee MY, Sleeman MW, Kulkarni RN, Musi N, Hirshman MF, Goodyear LJ
Nature communications 2013;4:1871
Nature communications 2013;4:1871
PPM1l encodes an inositol requiring-protein 1 (IRE1) specific phosphatase that regulates the functional outcome of the ER stress response.
Lu G, Ota A, Ren S, Franklin S, Rau CD, Ping P, Lane TF, Zhou ZH, Reue K, Lusis AJ, Vondriska T, Wang Y
Molecular metabolism 2013;2(4):405-16
Molecular metabolism 2013;2(4):405-16
Selection of autophagy or apoptosis in cells exposed to ER-stress depends on ATF4 expression pattern with or without CHOP expression.
Matsumoto H, Miyazaki S, Matsuyama S, Takeda M, Kawano M, Nakagawa H, Nishimura K, Matsuo S
Biology open 2013;2(10):1084-90
Biology open 2013;2(10):1084-90
Membrane lipid saturation activates IRE1α without inducing clustering.
Kitai Y, Ariyama H, Kono N, Oikawa D, Iwawaki T, Arai H
Genes to cells : devoted to molecular & cellular mechanisms 2013 Sep;18(9):798-809
Genes to cells : devoted to molecular & cellular mechanisms 2013 Sep;18(9):798-809
Inhibition of x-box binding protein 1 reduces tunicamycin-induced apoptosis in aged murine macrophages.
Song Y, Shen H, Du W, Goldstein DR
Aging cell 2013 Oct;12(5):794-801
Aging cell 2013 Oct;12(5):794-801
Endoplasmic reticulum stress signaling involvement in manganese-induced nerve cell damage in organotypic brain slice cultures.
Xu B, Shan M, Wang F, Deng Y, Liu W, Feng S, Yang TY, Xu ZF
Toxicology letters 2013 Oct 9;222(3):239-46
Toxicology letters 2013 Oct 9;222(3):239-46
ER stress in rodent islets of Langerhans is concomitant with obesity and β-cell compensation but not with β-cell dysfunction and diabetes.
Omikorede O, Qi C, Gorman T, Chapman P, Yu A, Smith DM, Herbert TP
Nutrition & diabetes 2013 Oct 21;3:e93
Nutrition & diabetes 2013 Oct 21;3:e93
Rutaecarpine analogues reduce lipid accumulation in adipocytes via inhibiting adipogenesis/lipogenesis with AMPK activation and UPR suppression.
Chen YC, Zeng XY, He Y, Liu H, Wang B, Zhou H, Chen JW, Liu PQ, Gu LQ, Ye JM, Huang ZS
ACS chemical biology 2013 Oct 18;8(10):2301-11
ACS chemical biology 2013 Oct 18;8(10):2301-11
The serine-threonine kinase inositol-requiring enzyme 1α (IRE1α) promotes IL-4 production in T helper cells.
Kemp KL, Lin Z, Zhao F, Gao B, Song J, Zhang K, Fang D
The Journal of biological chemistry 2013 Nov 15;288(46):33272-82
The Journal of biological chemistry 2013 Nov 15;288(46):33272-82
Paneth cells as a site of origin for intestinal inflammation.
Adolph TE, Tomczak MF, Niederreiter L, Ko HJ, Böck J, Martinez-Naves E, Glickman JN, Tschurtschenthaler M, Hartwig J, Hosomi S, Flak MB, Cusick JL, Kohno K, Iwawaki T, Billmann-Born S, Raine T, Bharti R, Lucius R, Kweon MN, Marciniak SJ, Choi A, Hagen SJ, Schreiber S, Rosenstiel P, Kaser A, Blumberg RS
Nature 2013 Nov 14;503(7475):272-6
Nature 2013 Nov 14;503(7475):272-6
Proteasome dysfunction mediates obesity-induced endoplasmic reticulum stress and insulin resistance in the liver.
Otoda T, Takamura T, Misu H, Ota T, Murata S, Hayashi H, Takayama H, Kikuchi A, Kanamori T, Shima KR, Lan F, Takeda T, Kurita S, Ishikura K, Kita Y, Iwayama K, Kato K, Uno M, Takeshita Y, Yamamoto M, Tokuyama K, Iseki S, Tanaka K, Kaneko S
Diabetes 2013 Mar;62(3):811-24
Diabetes 2013 Mar;62(3):811-24
Curcumin induces apoptotic cell death of activated human CD4+ T cells via increasing endoplasmic reticulum stress and mitochondrial dysfunction.
Zheng M, Zhang Q, Joe Y, Lee BH, Ryu DG, Kwon KB, Ryter SW, Chung HT
International immunopharmacology 2013 Mar;15(3):517-23
International immunopharmacology 2013 Mar;15(3):517-23
RNF13, a RING finger protein, mediates endoplasmic reticulum stress-induced apoptosis through the inositol-requiring enzyme (IRE1α)/c-Jun NH2-terminal kinase pathway.
Arshad M, Ye Z, Gu X, Wong CK, Liu Y, Li D, Zhou L, Zhang Y, Bay WP, Yu VC, Li P
The Journal of biological chemistry 2013 Mar 22;288(12):8726-36
The Journal of biological chemistry 2013 Mar 22;288(12):8726-36
X-box binding protein 1 is essential for insulin regulation of pancreatic α-cell function.
Akiyama M, Liew CW, Lu S, Hu J, Martinez R, Hambro B, Kennedy RT, Kulkarni RN
Diabetes 2013 Jul;62(7):2439-49
Diabetes 2013 Jul;62(7):2439-49
The ER stress-mediated decrease in DDAH1 expression is involved in formaldehyde-induced apoptosis in lung epithelial cells.
Lim SK, Choi H, Park MJ, Kim DI, Kim JC, Kim GY, Jeong SY, Rodionov RN, Han HJ, Yoon KC, Park SH
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013 Dec;62:763-9
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013 Dec;62:763-9
Pathological endoplasmic reticulum stress mediated by the IRE1 pathway contributes to pre-insulitic beta cell apoptosis in a virus-induced rat model of type 1 diabetes.
Yang C, Diiorio P, Jurczyk A, O'Sullivan-Murphy B, Urano F, Bortell R
Diabetologia 2013 Dec;56(12):2638-46
Diabetologia 2013 Dec;56(12):2638-46
Hepatic extracellular signal-regulated kinase 2 suppresses endoplasmic reticulum stress and protects from oxidative stress and endothelial dysfunction.
Kujiraoka T, Satoh Y, Ayaori M, Shiraishi Y, Arai-Nakaya Y, Hakuno D, Yada H, Kuwada N, Endo S, Isoda K, Adachi T
Journal of the American Heart Association 2013 Aug 16;2(4):e000361
Journal of the American Heart Association 2013 Aug 16;2(4):e000361
The unfolded protein response to endoplasmic reticulum stress in cultured astrocytes and rat brain during experimental diabetes.
Lind KR, Ball KK, Cruz NF, Dienel GA
Neurochemistry international 2013 Apr;62(5):784-95
Neurochemistry international 2013 Apr;62(5):784-95
ER stress signalling through eIF2α and CHOP, but not IRE1α, attenuates adipogenesis in mice.
Han J, Murthy R, Wood B, Song B, Wang S, Sun B, Malhi H, Kaufman RJ
Diabetologia 2013 Apr;56(4):911-24
Diabetologia 2013 Apr;56(4):911-24
Vitiligo-inducing phenols activate the unfolded protein response in melanocytes resulting in upregulation of IL6 and IL8.
Toosi S, Orlow SJ, Manga P
The Journal of investigative dermatology 2012 Nov;132(11):2601-9
The Journal of investigative dermatology 2012 Nov;132(11):2601-9
Cleaved cytokeratin-18 is a mechanistically informative biomarker in idiopathic pulmonary fibrosis.
Cha SI, Ryerson CJ, Lee JS, Kukreja J, Barry SS, Jones KD, Elicker BM, Kim DS, Papa FR, Collard HR, Wolters PJ
Respiratory research 2012 Nov 20;13:105
Respiratory research 2012 Nov 20;13:105
Insulin and insulin-like growth factor II differentially regulate endocytic sorting and stability of insulin receptor isoform A.
Morcavallo A, Genua M, Palummo A, Kletvikova E, Jiracek J, Brzozowski AM, Iozzo RV, Belfiore A, Morrione A
The Journal of biological chemistry 2012 Mar 30;287(14):11422-36
The Journal of biological chemistry 2012 Mar 30;287(14):11422-36
Sensing endoplasmic reticulum stress by protein kinase RNA-like endoplasmic reticulum kinase promotes adaptive mitochondrial DNA biogenesis and cell survival via heme oxygenase-1/carbon monoxide activity.
Zheng M, Kim SK, Joe Y, Back SH, Cho HR, Kim HP, Ignarro LJ, Chung HT
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 Jun;26(6):2558-68
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 Jun;26(6):2558-68
Acute hypoxia induces apoptosis of pancreatic β-cell by activation of the unfolded protein response and upregulation of CHOP.
Zheng X, Zheng X, Wang X, Ma Z, Gupta Sunkari V, Botusan I, Takeda T, Björklund A, Inoue M, Catrina SB, Brismar K, Poellinger L, Pereira TS
Cell death & disease 2012 Jun 14;3(6):e322
Cell death & disease 2012 Jun 14;3(6):e322
Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing.
Ri M, Tashiro E, Oikawa D, Shinjo S, Tokuda M, Yokouchi Y, Narita T, Masaki A, Ito A, Ding J, Kusumoto S, Ishida T, Komatsu H, Shiotsu Y, Ueda R, Iwawaki T, Imoto M, Iida S
Blood cancer journal 2012 Jul;2(7):e79
Blood cancer journal 2012 Jul;2(7):e79
Synergistic effects of nelfinavir and bortezomib on proteotoxic death of NSCLC and multiple myeloma cells.
Kawabata S, Gills JJ, Mercado-Matos JR, Lopiccolo J, Wilson W 3rd, Hollander MC, Dennis PA
Cell death & disease 2012 Jul 19;3:e353
Cell death & disease 2012 Jul 19;3:e353
Endoplasmic reticulum stress inhibits STAT3-dependent suppression of hepatic gluconeogenesis via dephosphorylation and deacetylation.
Kimura K, Yamada T, Matsumoto M, Kido Y, Hosooka T, Asahara S, Matsuda T, Ota T, Watanabe H, Sai Y, Miyamoto K, Kaneko S, Kasuga M, Inoue H
Diabetes 2012 Jan;61(1):61-73
Diabetes 2012 Jan;61(1):61-73
Endoplasmic reticulum stress does not mediate palmitate-induced insulin resistance in mouse and human muscle cells.
Hage Hassan R, Hainault I, Vilquin JT, Samama C, Lasnier F, Ferré P, Foufelle F, Hajduch E
Diabetologia 2012 Jan;55(1):204-14
Diabetologia 2012 Jan;55(1):204-14
Decreased expression of endoplasmic reticulum chaperone GRP78 in liver of diabetic mice.
Yamagishi N, Ueda T, Mori A, Saito Y, Hatayama T
Biochemical and biophysical research communications 2012 Jan 6;417(1):364-70
Biochemical and biophysical research communications 2012 Jan 6;417(1):364-70
Cdc37/Hsp90 protein-mediated regulation of IRE1α protein activity in endoplasmic reticulum stress response and insulin synthesis in INS-1 cells.
Ota A, Wang Y
The Journal of biological chemistry 2012 Feb 24;287(9):6266-74
The Journal of biological chemistry 2012 Feb 24;287(9):6266-74
Autophagy plays a protective role in endoplasmic reticulum stress-mediated pancreatic β cell death.
Bartolome A, Guillen C, Benito M
Autophagy 2012 Dec;8(12):1757-68
Autophagy 2012 Dec;8(12):1757-68
Involvement of X-box binding protein 1 and reactive oxygen species pathways in the pathogenesis of tumour necrosis factor receptor-associated periodic syndrome.
Dickie LJ, Aziz AM, Savic S, Lucherini OM, Cantarini L, Geiler J, Wong CH, Coughlan R, Lane T, Lachmann HJ, Hawkins PN, Robinson PA, Emery P, McGonagle D, McDermott MF
Annals of the rheumatic diseases 2012 Dec;71(12):2035-43
Annals of the rheumatic diseases 2012 Dec;71(12):2035-43
Endoplasmic reticulum (ER) stress in cumulus-oocyte complexes impairs pentraxin-3 secretion, mitochondrial membrane potential (DeltaPsi m), and embryo development.
Wu LL, Russell DL, Norman RJ, Robker RL
Molecular endocrinology (Baltimore, Md.) 2012 Apr;26(4):562-73
Molecular endocrinology (Baltimore, Md.) 2012 Apr;26(4):562-73
The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies.
Nijholt DA, van Haastert ES, Rozemuller AJ, Scheper W, Hoozemans JJ
The Journal of pathology 2012 Apr;226(5):693-702
The Journal of pathology 2012 Apr;226(5):693-702
Inhibition of enterovirus 71 entry by transcription factor XBP1.
Jheng JR, Lin CY, Horng JT, Lau KS
Biochemical and biophysical research communications 2012 Apr 20;420(4):882-7
Biochemical and biophysical research communications 2012 Apr 20;420(4):882-7
Pancreatic β-cells depend on basal expression of active ATF6α-p50 for cell survival even under nonstress conditions.
Teodoro T, Odisho T, Sidorova E, Volchuk A
American journal of physiology. Cell physiology 2012 Apr 1;302(7):C992-1003
American journal of physiology. Cell physiology 2012 Apr 1;302(7):C992-1003
HCV causes chronic endoplasmic reticulum stress leading to adaptation and interference with the unfolded protein response.
Merquiol E, Uzi D, Mueller T, Goldenberg D, Nahmias Y, Xavier RJ, Tirosh B, Shibolet O
PloS one 2011;6(9):e24660
PloS one 2011;6(9):e24660
Accumulation of wildtype and ALS-linked mutated VAPB impairs activity of the proteasome.
Moumen A, Virard I, Raoul C
PloS one 2011;6(10):e26066
PloS one 2011;6(10):e26066
Compromising the unfolded protein response induces autophagy-mediated cell death in multiple myeloma cells.
Michallet AS, Mondiere P, Taillardet M, Leverrier Y, Genestier L, Defrance T
PloS one 2011;6(10):e25820
PloS one 2011;6(10):e25820
Measuring ER stress and the unfolded protein response using mammalian tissue culture system.
Oslowski CM, Urano F
Methods in enzymology 2011;490:71-92
Methods in enzymology 2011;490:71-92
Measurement of ER stress response and inflammation in the mouse model of nonalcoholic fatty liver disease.
Zheng Z, Zhang C, Zhang K
Methods in enzymology 2011;489:329-48
Methods in enzymology 2011;489:329-48
Endoplasmic reticulum stress implicated in the development of renal fibrosis.
Chiang CK, Hsu SP, Wu CT, Huang JW, Cheng HT, Chang YW, Hung KY, Wu KD, Liu SH
Molecular medicine (Cambridge, Mass.) 2011;17(11-12):1295-305
Molecular medicine (Cambridge, Mass.) 2011;17(11-12):1295-305
BAX inhibitor-1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response.
Castillo K, Rojas-Rivera D, Lisbona F, Caballero B, Nassif M, Court FA, Schuck S, Ibar C, Walter P, Sierralta J, Glavic A, Hetz C
The EMBO journal 2011 Sep 16;30(21):4465-78
The EMBO journal 2011 Sep 16;30(21):4465-78
Resveratrol triggers the pro-apoptotic endoplasmic reticulum stress response and represses pro-survival XBP1 signaling in human multiple myeloma cells.
Wang FM, Galson DL, Roodman GD, Ouyang H
Experimental hematology 2011 Oct;39(10):999-1006
Experimental hematology 2011 Oct;39(10):999-1006
Inhibition of the unfolded protein response by ricin a-chain enhances its cytotoxicity in mammalian cells.
Wang CT, Jetzt AE, Cheng JS, Cohick WS
Toxins 2011 May;3(5):453-68
Toxins 2011 May;3(5):453-68
Cannabidiol causes activated hepatic stellate cell death through a mechanism of endoplasmic reticulum stress-induced apoptosis.
Lim MP, Devi LA, Rozenfeld R
Cell death & disease 2011 Jun 9;2:e170
Cell death & disease 2011 Jun 9;2:e170
Endoplasmic reticulum stress induces autophagy through activation of p38 MAPK in fibroblasts from Pompe disease patients carrying c.546G>T mutation.
Shimada Y, Kobayashi H, Kawagoe S, Aoki K, Kaneshiro E, Shimizu H, Eto Y, Ida H, Ohashi T
Molecular genetics and metabolism 2011 Dec;104(4):566-73
Molecular genetics and metabolism 2011 Dec;104(4):566-73
Magnolol down-regulates HER2 gene expression, leading to inhibition of HER2-mediated metastatic potential in ovarian cancer cells.
Chuang TC, Hsu SC, Cheng YT, Shao WS, Wu K, Fang GS, Ou CC, Wang V
Cancer letters 2011 Dec 1;311(1):11-9
Cancer letters 2011 Dec 1;311(1):11-9
Overexpression of Insig-1 protects β cell against glucolipotoxicity via SREBP-1c.
Chen K, Jin P, He HH, Xie YH, Xie XY, Mo ZH
Journal of biomedical science 2011 Aug 16;18:57
Journal of biomedical science 2011 Aug 16;18:57
Involvement of endoplasmic reticulum stress defined by activated unfolded protein response in multiple system atrophy.
Makioka K, Yamazaki T, Fujita Y, Takatama M, Nakazato Y, Okamoto K
Journal of the neurological sciences 2010 Oct 15;297(1-2):60-5
Journal of the neurological sciences 2010 Oct 15;297(1-2):60-5
Circadian clock-coordinated 12 Hr period rhythmic activation of the IRE1alpha pathway controls lipid metabolism in mouse liver.
Cretenet G, Le Clech M, Gachon F
Cell metabolism 2010 Jan;11(1):47-57
Cell metabolism 2010 Jan;11(1):47-57
A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells.
Qiu Y, Mao T, Zhang Y, Shao M, You J, Ding Q, Chen Y, Wu D, Xie D, Lin X, Gao X, Kaufman RJ, Li W, Liu Y
Science signaling 2010 Jan 26;3(106):ra7
Science signaling 2010 Jan 26;3(106):ra7
AAV-mediated expression of wild-type and ALS-linked mutant VAPB selectively triggers death of motoneurons through a Ca2+-dependent ER-associated pathway.
Langou K, Moumen A, Pellegrino C, Aebischer J, Medina I, Aebischer P, Raoul C
Journal of neurochemistry 2010 Aug;114(3):795-809
Journal of neurochemistry 2010 Aug;114(3):795-809
A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response.
Winnay JN, Boucher J, Mori MA, Ueki K, Kahn CR
Nature medicine 2010 Apr;16(4):438-45
Nature medicine 2010 Apr;16(4):438-45
Astragalus polysaccharides decreased the expression of PTP1B through relieving ER stress induced activation of ATF6 in a rat model of type 2 diabetes.
Wang N, Zhang D, Mao X, Zou F, Jin H, Ouyang J
Molecular and cellular endocrinology 2009 Aug 13;307(1-2):89-98
Molecular and cellular endocrinology 2009 Aug 13;307(1-2):89-98
The unfolded protein response is activated in pretangle neurons in Alzheimer's disease hippocampus.
Hoozemans JJ, van Haastert ES, Nijholt DA, Rozemuller AJ, Eikelenboom P, Scheper W
The American journal of pathology 2009 Apr;174(4):1241-51
The American journal of pathology 2009 Apr;174(4):1241-51
Down-regulation of inhibition of differentiation-1 via activation of activating transcription factor 3 and Smad regulates REIC/Dickkopf-3-induced apoptosis.
Kashiwakura Y, Ochiai K, Watanabe M, Abarzua F, Sakaguchi M, Takaoka M, Tanimoto R, Nasu Y, Huh NH, Kumon H
Cancer research 2008 Oct 15;68(20):8333-41
Cancer research 2008 Oct 15;68(20):8333-41
AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress response.
Luo D, He Y, Zhang H, Yu L, Chen H, Xu Z, Tang S, Urano F, Min W
The Journal of biological chemistry 2008 May 2;283(18):11905-12
The Journal of biological chemistry 2008 May 2;283(18):11905-12
Serine 129 phosphorylation of alpha-synuclein induces unfolded protein response-mediated cell death.
Sugeno N, Takeda A, Hasegawa T, Kobayashi M, Kikuchi A, Mori F, Wakabayashi K, Itoyama Y
The Journal of biological chemistry 2008 Aug 22;283(34):23179-88
The Journal of biological chemistry 2008 Aug 22;283(34):23179-88
Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1.
Lipson KL, Fonseca SG, Ishigaki S, Nguyen LX, Foss E, Bortell R, Rossini AA, Urano F
Cell metabolism 2006 Sep;4(3):245-54
Cell metabolism 2006 Sep;4(3):245-54
No comments: Submit comment
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: IRE1 alpha [p Ser724] Antibody [NB100-2323] - Analysis of anti-IRE1 alpha (pSer724) using Lot AN and AO of NB100-2323. HeLa cells were treated (+) or untreated (-) with 10 mM DTT for 60 min to activate the UPR. Total protein was separated on a 7.5% gel by SDS-PAGE, transferred to PVDF membrane and blocked in 5% BSA in TBST. The membrane was probed with 2.0 ug/ml antibody in 5% BSA, and detected with an anti-rabbit HRP secondary antibody using chemiluminescence. Theoretical molecular weight: 110 kDa.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: IRE1 alpha [p Ser724] Antibody [NB100-2323] - Analysis using HRP conjugate of NB100-2323. Detection of phosphorylated IRE-1 alpha using NB100-2323. Lane 1: COS-7 untransfected Lane 2: COS-7 expressing wild-type IRE1 alpha Lane 3: COS-7 expressing kinase-dead IRE1 alpha. Theoretical molecular weight: 110 kDa.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: IRE1 alpha [p Ser724] Antibody [NB100-2323] - Detection in Min6 cells which were treated with different concentrations of glucose for 3 hours prior to lysates preparation.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: IRE1 alpha [p Ser724] Antibody [NB100-2323] - Hepatic ER stress markers with cachexia progression. ER stress markers Bip, IRE1a, ATF6p50 and CHOP were examined in the liver of non, pre and severely cachectic mice. (n = 6-8 per group, p < 0.05) Dotted line indicates levels of Non-cachectic mice. Non = Non-Cachectic Apc Min/+ Sev = severely cachectic Apc Min/+; * denotes significantly different from Non-cachectic Apc Min/+ Image collected and cropped by CiteAb from the following publication (//doi.org/10.1371/journal.pone.0119888) licensed under a CC-BY licence.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: IRE1 alpha [p Ser724] Antibody [NB100-2323] - IRF-1 plays a central role in ER stress-mediated modulation of VCAM-1 expression by TGRL. HAEC were conditioned for 4 hr with TNFa (0.3 ng/ml) E: CHOP knockdown decreased TNFa-induced VCAM-1 expression. n=4. **P
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: IRE1 alpha [p Ser724] Antibody [NB100-2323] - Regulation of the unfolded protein response by KLF15. Western analysis of UPR activity in WT versus KLF15-/- primary hepatocytes. Hepatocytes were isolated from standard chow-fed 4-month-old male WT and KLF15 -/- mice. Two individual experiments were performed in triplicate; each lane indicates a technical replicate. Image collected and cropped by CiteAb from the following publication (//doi.org/10.1371/journal.pone.0077851) licensed under a CC-BY licence.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: IRE1 alpha [p Ser724] Antibody [NB100-2323] - IRE1 (pS724) was detected in immersion fixed paraffin-embedded sections of human spleen using Rabbit Anti-Human IRE1 (pS724) polyclonal Antibody (Catalog # NB100-2323) at 1:300 for 1 hour at room temperature followed by incubation with the Anti-Rabbit IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC003). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to the perinuclear cytoplasm in splenocytes.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry: IRE1 alpha [p Ser724] Antibody [NB100-2323] - P-Ire1a activation correlates with WFS1 cell expression. Cryosections of retina from 12 month old Wfs1+/+ and Wfs1-/- mouse were immunostained with anti-P-Ire1a antibody (red). DAPI was used for staining of cell nuclei (blue). RPE, retinal pigment epithelium; ONL, outer nuclear layer; INL, inner nuclear layer, RGC, retinal ganglion cells. Scale bars=50 um. Image collected and cropped by CiteAb from the following publication (//doi.org/10.1371/journal.pone.0097222) licensed under a CC-BY licence.
