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Protein structure
ERN1
Endoplasmic reticulum to nucleus signaling 1IRE1, IRE1P
This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1. [provided by RefSeq, Aug 2017]
Top validated antibodies |
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| Novus Biologicals |  NB100-2323 |
208 references | Polyclonal |
WB
EL
ICC
IP
IHC
ChIP
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| Invitrogen Antibodies | PA1-16927 |
61 references | Polyclonal |
WB
EL
IP
IHC
ChIP
OA
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| Boster Biological Technology | A00683-1 |
11 references | Polyclonal |
WB
EL
ICC
FC
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| antibodies-online | ABIN250711 |
17 references | Polyclonal |
WB
ICC
IHC
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| Proteintech Group | 27528-1-AP |
91 references | Polyclonal |
WB
EL
IHC
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