TBX21

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]

Description

T-box transcription factor 21

Tissue specificity

Group enriched (bone marrow, lung, lymphoid tissue)

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transcription factors

Chromosome

17 (47733236 - 47746122)

Ensembl ID

ENSG00000073861  (ver. 103.38)

Orthologs

Mouse Tbx21: ENSMUSG00000001444

UniProt

Q9UL17

neXtProt

NX_Q9UL17

Human splice variants
Mouse splice variants

Protein structure