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Protein structure
DDIT3
DNA damage inducible transcript 3CHOP, CHOP10, GADD153
This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010]
Top validated antibodies |
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| Novus Biologicals |  NB600-1335 |
35 references | Monoclonal |
WB
EL
ICC
IP
IHC
FC
GS
ChIP
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| Proteintech Group | 15204-1-AP |
251 references | Polyclonal |
WB
EL
IHC
FC
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| Invitrogen Antibodies | MA1-250 |
84 references | Monoclonal |
WB
ICC
OA
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| Cell Signaling Technology, Inc | 2895 |
1 references | Monoclonal |
WB
ICC
IP
FC
ChIP
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| antibodies-online | ABIN269517 |
17 references | Monoclonal |
WB
ICC
IP
IHC
GS
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