Tissue expression
Cell line expression
Protein structure
PSENEN
Presenilin enhancer, gamma-secretase subunitPEN2
Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Top validated antibodies |
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Invitrogen Antibodies | MA5-34830 | Monoclonal |
WB
ICC
IHC
FC |
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antibodies-online | ABIN500471 | 4 references | Polyclonal |
WB
EL
ICC
|
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GeneTex | GTX85063 | Polyclonal |
WB
EL
ICC
IHC |
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Novus Biologicals | NBP2-75632 | Monoclonal |
WB
ICC
IHC
FC |
||
Boster Biological Technology | A04504-1 | Polyclonal |
WB
ICC
IHC
FC |
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