HLA-DQA2

This gene belongs to the HLA class II alpha chain family. The encoded protein forms a heterodimer with a class II beta chain. It is located in intracellular vesicles and plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (B lymphocytes, dendritic cells, macrophages) and are used to present antigenic peptides on the cell surface to be recognized by CD4 T-cells. [provided by RefSeq, Jun 2010]

Description

Major histocompatibility complex, class II, DQ alpha 2

Tissue specificity

Tissue enhanced (lung, lymphoid tissue)

Predicted location

Membrane

Protein family

Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins

Chromosome

6 (32741391 - 32747198)

Ensembl ID

ENSG00000237541  (ver. 103.38)

Orthologs

-

UniProt

P01906

neXtProt

NX_P01906

Human splice variants

Protein structure