NLRP6

The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

Description

NLR family pyrin domain containing 6

Tissue specificity

Tissue enriched (intestine)

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

11 (278407 - 285388)

Ensembl ID

ENSG00000174885  (ver. 103.38)

Orthologs

Mouse Nlrp6: ENSMUSG00000038745

UniProt

P59044

neXtProt

NX_P59044

Human splice variants
Mouse splice variants

Protein structure