orb131830

antibody from Biorbyt

Targeting: STAT3 APRF

Western blot

Antibody data

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Validation data

Product number: orb131830 - Provider product page
Provider: Biorbyt
Product name: STAT3 antibody
Antibody type: Polyclonal
Description: Rabbit polyclonal to STAT3. Signal transducer and activator of transcription 3 (STAT3) is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo-or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT3 is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. STAT3 mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of STAT3. PIAS3 protein is a specific inhibitor of STAT3. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Vial size: 100 ul
Concentration: 100 μg/ml BSA
Storage: -20°C

STAT3 protein structure - orb131830 shown in red.