Antibody data
- Antibody Data
- Antigen structure
- References [24]
- Comments [0]
- Validations [0]
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- Product number
- PB9511 - Provider product page
- Provider
- Boster Biological Technology
- Product name
- Anti-STAT3 Antibody Picoband™
- Antibody type
- Polyclonal
- Description
- Polyclonal antibody for STAT3 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: WB. Reactive species: Human. STAT3 information: Molecular Weight: 88068 MW; Subcellular Localization: Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1; Tissue Specificity: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Vial size
- 100μg/vial
- Concentration
- Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
- Storage
- At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquoted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
- Handling
- Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Submitted references α-Linolenic acid ameliorates pentylenetetrazol-induced neuron apoptosis and neurological impairment in mice with seizures via down-regulating JAK2/STAT3 pathway.
Modified Biejia Jianwan decoction restrains PD-L1-mediated immune evasion through the HIF-1α/STAT3/NF-κB signaling pathway.
Langat virus inhibits the gp130/JAK/STAT signaling by reducing the gp130 protein level.
Integration analysis using bioinformatics and experimental validation on the clinical and biological significance of TSLP in cancers.
Synthesis, biological activity and mechanism of action of novel allosecurinine derivatives as potential antitumor agents.
Cryptotanshinone ameliorates MPP(+)-induced oxidative stress and apoptosis of SH-SY5Y neuroblastoma cells: the role of STAT3 in Parkinson's disease.
miR-21, miR-125b, and let-7b contribute to the involution of atretic follicles and corpus lutea in Tibetan sheep ovaries.
Triptolide attenuates LPS-induced activation of RAW 264.7 macrophages by inducing M1-to-M2 repolarization via the mTOR/STAT3 signaling.
TIAM2 promotes proliferation and invasion of osteosarcoma cells by activating the JAK2/STAT3 signaling pathway.
Overexpression of miR-125a-5p Inhibits Hepatocyte Proliferation through the STAT3 Regulation In Vivo and In Vitro.
High-Fat Diet-Related Obesity Promotes Urethane-Induced Lung Tumorigenesis in C57BL/6J Mice.
Juglone regulates gut microbiota and Th17/Treg balance in DSS-induced ulcerative colitis.
JAK2-STAT3 signaling pathway is involved in rat periapical lesions induced by Enterococcus faecalis.
Glycosylation of dentin matrix protein 1 is critical for fracture healing via promoting chondrogenesis.
MiR-296-3p may affect the proliferation and migration of non-small cell lung cancer cells via regulating RABL3.
ELP2 negatively regulates osteoblastic differentiation impaired by tumor necrosis factor α in MC3T3-E1 cells through STAT3 activation.
Celecoxib suppresses proliferation and metastasis of pancreatic cancer cells by down-regulating STAT3 / NF-kB and L1CAM activities.
Autophagy suppresses isoprenaline-induced M2 macrophage polarization via the ROS/ERK and mTOR signaling pathway.
The role of cofilin-l in vulvar squamous cell carcinoma: A marker of carcinogenesis, progression and targeted therapy.
The effects of STAT3 and Survivin silencing on the growth of human bladder carcinoma cells.
Effect of iodine excess on Th1, Th2, Th17, and Treg cell subpopulations in the thyroid of NOD.H-2h4 mice.
Cucurbitacin B inhibits growth and induces apoptosis through the JAK2/STAT3 and MAPK pathways in SH‑SY5Y human neuroblastoma cells.
Delivery of the co-expression plasmid pEndo-Si-Stat3 by attenuated Salmonella serovar typhimurium for prostate cancer treatment.
The effects of HIF-1alpha on gene expression profiles of NCI-H446 human small cell lung cancer cells.
Zeng X, Luo F, Cheng YH, Gao J, Hong D
The British journal of nutrition 2024 May 22;:1-12
The British journal of nutrition 2024 May 22;:1-12
Modified Biejia Jianwan decoction restrains PD-L1-mediated immune evasion through the HIF-1α/STAT3/NF-κB signaling pathway.
Tian X, Liu F, Wang Z, Zhang J, Liu Q, Zhang Y, Zhang D, Huang C, Zhao J, Jiang S
Journal of ethnopharmacology 2024 Mar 25;322:117577
Journal of ethnopharmacology 2024 Mar 25;322:117577
Langat virus inhibits the gp130/JAK/STAT signaling by reducing the gp130 protein level.
Lin S, Wang X, Sallapalli BT, Hage A, Chang P, He J, Best SM, Zhang Y
Journal of medical virology 2024 Apr;96(4):e29522
Journal of medical virology 2024 Apr;96(4):e29522
Integration analysis using bioinformatics and experimental validation on the clinical and biological significance of TSLP in cancers.
Qu H, Liu X, Jiang T, Huang G, Cai H, Xing D, Mao Y, Zheng X
Cellular signalling 2023 Nov;111:110874
Cellular signalling 2023 Nov;111:110874
Synthesis, biological activity and mechanism of action of novel allosecurinine derivatives as potential antitumor agents.
Xu XL, Lan JX, Huang H, Dai W, Peng XP, Liu SL, Chen WM, Huang LJ, Liu J, Li XJ, Zeng JL, Huang XH, Zhao GN, Hou W
Bioorganic & medicinal chemistry 2023 Mar 15;82:117234
Bioorganic & medicinal chemistry 2023 Mar 15;82:117234
Cryptotanshinone ameliorates MPP(+)-induced oxidative stress and apoptosis of SH-SY5Y neuroblastoma cells: the role of STAT3 in Parkinson's disease.
Wang Q, Liu Y
Metabolic brain disease 2022 Jun;37(5):1477-1485
Metabolic brain disease 2022 Jun;37(5):1477-1485
miR-21, miR-125b, and let-7b contribute to the involution of atretic follicles and corpus lutea in Tibetan sheep ovaries.
Zhang T, Huo S, Wei S, Cui S
Animal science journal = Nihon chikusan Gakkaiho 2022 Jan-Dec;93(1):e13756
Animal science journal = Nihon chikusan Gakkaiho 2022 Jan-Dec;93(1):e13756
Triptolide attenuates LPS-induced activation of RAW 264.7 macrophages by inducing M1-to-M2 repolarization via the mTOR/STAT3 signaling.
Zhu H, Tong S, Yan C, Zhou A, Wang M, Li C
Immunopharmacology and immunotoxicology 2022 Dec;44(6):894-901
Immunopharmacology and immunotoxicology 2022 Dec;44(6):894-901
TIAM2 promotes proliferation and invasion of osteosarcoma cells by activating the JAK2/STAT3 signaling pathway.
Cheng S, Huang X, Guo W
Journal of bone oncology 2022 Dec;37:100461
Journal of bone oncology 2022 Dec;37:100461
Overexpression of miR-125a-5p Inhibits Hepatocyte Proliferation through the STAT3 Regulation In Vivo and In Vitro.
Zhang C, Zhao Y, Wang Q, Qin J, Ye B, Xu C, Yu G
International journal of molecular sciences 2022 Aug 4;23(15)
International journal of molecular sciences 2022 Aug 4;23(15)
High-Fat Diet-Related Obesity Promotes Urethane-Induced Lung Tumorigenesis in C57BL/6J Mice.
Shi D, Wu J, Wu Y, Lin X, Xu C, Lian X
Frontiers in oncology 2021;11:620993
Frontiers in oncology 2021;11:620993
Juglone regulates gut microbiota and Th17/Treg balance in DSS-induced ulcerative colitis.
Hua Y, Liu R, Lu M, Guan X, Zhuang S, Tian Y, Zhang Z, Cui L
International immunopharmacology 2021 Aug;97:107683
International immunopharmacology 2021 Aug;97:107683
JAK2-STAT3 signaling pathway is involved in rat periapical lesions induced by Enterococcus faecalis.
Wang L, Jin H, Ao X, Dong M, Liu S, Lu Y, Niu W
Oral diseases 2019 Oct;25(7):1769-1779
Oral diseases 2019 Oct;25(7):1769-1779
Glycosylation of dentin matrix protein 1 is critical for fracture healing via promoting chondrogenesis.
Xue H, Tao D, Weng Y, Fan Q, Zhou S, Zhang R, Zhang H, Yue R, Wang X, Wang Z, Sun Y
Frontiers of medicine 2019 Oct;13(5):575-589
Frontiers of medicine 2019 Oct;13(5):575-589
MiR-296-3p may affect the proliferation and migration of non-small cell lung cancer cells via regulating RABL3.
Ge T, Wu HC, Zhou YY, Shen SM, Zhu LG, You GX
European review for medical and pharmacological sciences 2019 Jul;23(13):5823-5830
European review for medical and pharmacological sciences 2019 Jul;23(13):5823-5830
ELP2 negatively regulates osteoblastic differentiation impaired by tumor necrosis factor α in MC3T3-E1 cells through STAT3 activation.
Xu CP, Sun HT, Yang YJ, Cui Z, Wang J, Yu B, Wang FZ, Yang QP, Qi Y
Journal of cellular physiology 2019 Aug;234(10):18075-18085
Journal of cellular physiology 2019 Aug;234(10):18075-18085
Celecoxib suppresses proliferation and metastasis of pancreatic cancer cells by down-regulating STAT3 / NF-kB and L1CAM activities.
Zuo C, Hong Y, Qiu X, Yang D, Liu N, Sheng X, Zhou K, Tang B, Xiong S, Ma M, Liu Z
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2018 Apr;18(3):328-333
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2018 Apr;18(3):328-333
Autophagy suppresses isoprenaline-induced M2 macrophage polarization via the ROS/ERK and mTOR signaling pathway.
Shan M, Qin J, Jin F, Han X, Guan H, Li X, Zhang J, Zhang H, Wang Y
Free radical biology & medicine 2017 Sep;110:432-443
Free radical biology & medicine 2017 Sep;110:432-443
The role of cofilin-l in vulvar squamous cell carcinoma: A marker of carcinogenesis, progression and targeted therapy.
Wu Q, Jiang Y, Cui S, Wang Y, Wu X
Oncology reports 2016 May;35(5):2743-54
Oncology reports 2016 May;35(5):2743-54
The effects of STAT3 and Survivin silencing on the growth of human bladder carcinoma cells.
Zhang B, Lu Z, Hou Y, Hu J, Wang C
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2014 Jun;35(6):5401-7
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2014 Jun;35(6):5401-7
Effect of iodine excess on Th1, Th2, Th17, and Treg cell subpopulations in the thyroid of NOD.H-2h4 mice.
Yang X, Gao T, Shi R, Zhou X, Qu J, Xu J, Shan Z, Teng W
Biological trace element research 2014 Jun;159(1-3):288-96
Biological trace element research 2014 Jun;159(1-3):288-96
Cucurbitacin B inhibits growth and induces apoptosis through the JAK2/STAT3 and MAPK pathways in SH‑SY5Y human neuroblastoma cells.
Zheng Q, Liu Y, Liu W, Ma F, Zhou Y, Chen M, Chang J, Wang Y, Yang G, He G
Molecular medicine reports 2014 Jul;10(1):89-94
Molecular medicine reports 2014 Jul;10(1):89-94
Delivery of the co-expression plasmid pEndo-Si-Stat3 by attenuated Salmonella serovar typhimurium for prostate cancer treatment.
Li X, Li Y, Wang B, Ji K, Liang Z, Guo B, Hu J, Yin D, Du Y, Kopecko DJ, Kalvakolanu DV, Zhao X, Xu D, Zhang L
Journal of cancer research and clinical oncology 2013 Jun;139(6):971-80
Journal of cancer research and clinical oncology 2013 Jun;139(6):971-80
The effects of HIF-1alpha on gene expression profiles of NCI-H446 human small cell lung cancer cells.
Wan J, Ma J, Mei J, Shan G
Journal of experimental & clinical cancer research : CR 2009 Dec 10;28(1):150
Journal of experimental & clinical cancer research : CR 2009 Dec 10;28(1):150
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