ZAP70

gene product
SRK, STD, ZAP-70
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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1317 antibodies from 37 providers.

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AntibodyRefsTypeKDWBELICCIPIHCFC
NSJ Bioreagents
7 antibodies
antibodies-online
475 antibodies
NovoPro Bioscience Inc.
15 antibodies
Cell Signaling Technology, Inc
13 antibodies
Abnova Corporation
26 antibodies
Novus Biologicals
48 antibodies
Invitrogen Antibodies
25 antibodies
Signalway Antibody LLC
4 antibodies
GeneTex
22 antibodies
OriGene
18 antibodies
Abgent
12 antibodies
Proteintech Group
4 antibodies
LifeSpan BioSciences, Inc.
155 antibodies