Tissue expression
Cell line expression
Protein structure
ZAP70
Zeta chain of T cell receptor associated protein kinase 70SRK, STD, ZAP-70
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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GeneTex | GTX107950 | 1 references | Polyclonal |
WB
ICC
IP
IHC |
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NSJ Bioreagents | V2934 | 9 references | Monoclonal |
WB
ICC
IHC
FC
OA
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Invitrogen Antibodies | 14-6695-82 | 5 references | Monoclonal |
WB
ICC
IP
FC |
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NovoPro Bioscience Inc. | 116905 | Polyclonal |
WB
EL
ICC
IP
IHC
FC |
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FineTest Biotech | FNab09583 | Polyclonal |
WB
EL
ICC
IP
IHC
FC |
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