37-6500

Tromp JM, Geest CR, Breij EC, Elias JA, van Laar J, Luijks DM, Kater AP, Beaumont T, van Oers MH, Eldering E
Clinical cancer research : an official journal of the American Association for Cancer Research 2012 Jan 15;18(2):487-98

Quantitative analysis of protein phosphorylations and interactions by multi-colour IP-FCM as an input for kinetic modelling of signalling networks.

Deswal S, Schulze AK, Höfer T, Schamel WW
PloS one 2011;6(7):e22928

Improved ZAP-70 assay using two clones, multiple methods of analysis and clinical correlation.

Degheidy HA, Venzon DJ, Farooqui MZ, Abbasi F, Arthur DC, Wilson WH, Wiestner A, Stetler-Stevenson MA, Marti GE
Cytometry. Part B, Clinical cytometry 2011 Sep;80(5):309-17

Methodological comparison of two anti-ZAP-70 antibodies.

Degheidy HA, Venzon DJ, Farooqui MZ, Abbasi F, Arthur DC, Wilson WH, Wiestner A, Stetler-Stevenson MA, Marti GE
Cytometry. Part B, Clinical cytometry 2011 Sep;80(5):300-8

Prospective study of clinical and biological prognostic factors at diagnosis in patients with early stage B-cell chronic lymphocytic leukemia.

Oliveira AC, de la Banda E, Domingo-Domenech E, Encuentra M, Mercadal S, Domingo A, Alonso E, Espinet B, Grau J, De Sevilla AF, Gonzalez-Barca E
Leukemia & lymphoma 2011 Mar;52(3):429-35

High expression of the immature laminin receptor protein correlates with mutated IGVH status and predicts a favorable prognosis in chronic lymphocytic leukemia.

Friedrichs B, Siegel S, Reimer R, Barsoum A, Coggin J Jr, Kabelitz D, Heidorn K, Schulte C, Schmitz N, Zeis M
Leukemia research 2011 Jun;35(6):721-9

FCRL6 receptor: expression and associated proteins.

Kulemzin SV, Zamoshnikova AY, Yurchenko MY, Vitak NY, Najakshin AM, Fayngerts SA, Chikaev NA, Reshetnikova ES, Kashirina NM, Peclo MM, Rutkevich PN, Shevelev AY, Yanushevskaya EV, Baranov KO, Mamonkin M, Vlasik TN, Sidorenko SP, Taranin AV, Mechetina LV
Immunology letters 2011 Jan 30;134(2):174-82

Cluster analysis of immunophenotypic data: the example of chronic lymphocytic leukemia.

Zucchetto A, Cattarossi I, Nanni P, Zaina E, Prato G, Gilestro M, Marconi D, Bulian P, Rossi FM, Del Vecchio L, Omedè P, Geuna M, Del Poeta G, Gattei V
Immunology letters 2011 Jan 30;134(2):137-44

Significant change in ZAP-70 expression during the course of chronic lymphocytic leukemia.

Vroblova V, Vrbacky F, Hrudkova M, Jankovicova K, Schmitzova D, Maly J, Krejsek J, Smolej L
European journal of haematology 2010 Jun;84(6):513-7

Recruitment of PKC-betaII to lipid rafts mediates apoptosis-resistance in chronic lymphocytic leukemia expressing ZAP-70.

zum Büschenfelde CM, Wagner M, Lutzny G, Oelsner M, Feuerstacke Y, Decker T, Bogner C, Peschel C, Ringshausen I
Leukemia 2010 Jan;24(1):141-52

Humoral immune responses against the immature laminin receptor protein show prognostic significance in patients with chronic lymphocytic leukemia.

Friedrichs B, Siegel S, Kloess M, Barsoum A, Coggin J Jr, Rohrer J, Jakob I, Tiemann M, Heidorn K, Schulte C, Kabelitz D, Steinmann J, Schmitz N, Zeis M
Journal of immunology (Baltimore, Md. : 1950) 2008 May 1;180(9):6374-84

Humoral immune responses against the immature laminin receptor protein show prognostic significance in patients with chronic lymphocytic leukemia.

Optimization of flow cytometric measurement of ZAP-70 in chronic lymphocytic leukemia.

Preobrazhensky SN, Bahler DW
Cytometry. Part B, Clinical cytometry 2008 Mar;74(2):118-27

FCRL2 expression predicts IGHV mutation status and clinical progression in chronic lymphocytic leukemia.

Li FJ, Ding S, Pan J, Shakhmatov MA, Kashentseva E, Wu J, Li Y, Soong SJ, Chiorazzi N, Davis RS
Blood 2008 Jul 1;112(1):179-87

An improved flow cytometric method using FACS Lysing Solution for measurement of ZAP-70 expression in B-cell chronic lymphocytic leukemia.

Bekkema R, Tadema A, Daenen SM, Kluin-Nelemans HC, Mulder AB
Cytometry. Part B, Clinical cytometry 2008 Jan;74(1):40-4

Multicenter study of ZAP-70 expression in patients with B-cell chronic lymphocytic leukemia using an optimized flow cytometry method.

Gachard N, Salviat A, Boutet C, Arnoulet C, Durrieu F, Lenormand B, Leprêtre S, Olschwang S, Jardin F, Lafage-Pochitaloff M, Penther D, Sainty D, Reminieras L, Feuillard J, Béné MC, GEIL
Haematologica 2008 Feb;93(2):215-23

Comprehensive biomarker and genomic analysis identifies p53 status as the major determinant of response to MDM2 inhibitors in chronic lymphocytic leukemia.

Saddler C, Ouillette P, Kujawski L, Shangary S, Talpaz M, Kaminski M, Erba H, Shedden K, Wang S, Malek SN
Blood 2008 Feb 1;111(3):1584-93

National standardization of ZAP-70 determination by flow cytometry: the French experience.

Le Garff-Tavernier M, Ticchioni M, Brissard M, Salmon C, Raynaud S, Davi F, Bernard A, Merle-Béral H, Ajchenbaum-Cymbalista F, Letestu R
Cytometry. Part B, Clinical cytometry 2007 Mar;72(2):103-8

ZAP-70 expression, as detected by immunohistochemistry on bone marrow biopsies from early-phase CLL patients, is a strong adverse prognostic factor.

Zanotti R, Ambrosetti A, Lestani M, Ghia P, Pattaro C, Remo A, Zanetti F, Stella S, Perbellini O, Prato G, Guida G, Caligaris-Cappio F, Menestrina F, Pizzolo G, Chilosi M
Leukemia 2007 Jan;21(1):102-9

Familial B-cell chronic lymphocytic leukemia: analysis of cytogenetic abnormalities, immunophenotypic profiles, and immunoglobulin heavy chain gene usage.

Aoun P, Zhou G, Chan WC, Page C, Neth K, Pickering D, Sanger W, Quinn-Laquer B, Watson P, Lynch JF, Lynch HT, Weisenburger DD
American journal of clinical pathology 2007 Jan;127(1):31-8

Modern prognostic factors and angiogenesis in chronic lymphocytic leukemia: more data needed.

Smolej L, Andrys C, Vroblova V
Leukemia research 2007 Dec;31(12):1763-4

The effect of immunoglobulin VH gene mutation status and other prognostic factors on the incidence of major infections in patients with chronic lymphocytic leukemia.

Francis S, Karanth M, Pratt G, Starczynski J, Hooper L, Fegan C, Pepper C, Valcarcel D, Milligan DW, Delgado J
Cancer 2006 Sep 1;107(5):1023-33

Feasibility of an easily applicable method of ZAP-70 measurement in chronic lymphocytic leukemia in the routine flow cytometry setting: A methodological approach.

Passam F, Tachynopoulou V, Skoumi D, Tsompanakou A, Stavropoulos-Giokas A, Vadikolia C, Anagnostopoulos A, Paterakis G
Annals of hematology 2006 Nov;85(11):795-805

A scoring system based on the expression of six surface molecules allows the identification of three prognostic risk groups in B-cell chronic lymphocytic leukemia.

Zucchetto A, Bomben R, Dal Bo M, Sonego P, Nanni P, Rupolo M, Bulian P, Dal Maso L, Del Poeta G, Del Principe MI, Degan M, Gattei V
Journal of cellular physiology 2006 May;207(2):354-63

Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells.

de Totero D, Meazza R, Zupo S, Cutrona G, Matis S, Colombo M, Balleari E, Pierri I, Fabbi M, Capaia M, Azzarone B, Gobbi M, Ferrarini M, Ferrini S
Blood 2006 May 1;107(9):3708-15

Comparison of bone marrow and peripheral blood ZAP-70 status examined by flow cytometric immunophenotyping in patients with chronic lymphocytic leukemia.

Sheridan R, Mounajjed T, Ehrmann DE, Hurtubise PE, Schrager JA
Cytometry. Part B, Clinical cytometry 2006 Jul 15;70(4):320-1

Evaluation of ZAP-70 expression by flow cytometry in chronic lymphocytic leukemia: A multicentric international harmonization process.

Letestu R, Rawstron A, Ghia P, Villamor N, Boeckx N, Boettcher S, Buhl AM, Duerig J, Ibbotson R, Kroeber A, Langerak A, Le Garff-Tavernier M, Mockridge I, Morilla A, Padmore R, Rassenti L, Ritgen M, Shehata M, Smolewski P, Staib P, Ticchioni M, Walker C, Ajchenbaum-Cymbalista F
Cytometry. Part B, Clinical cytometry 2006 Jul 15;70(4):309-14

Comparison of methods for determining zeta-chain associated protein - 70 (ZAP-70) expression in patients with B-cell chronic lymphocytic leukemia (B-CLL).

Bojarska-Junak A, Giannopoulos K, Kowal M, Dmoszyńska A, Roliński J
Cytometry. Part B, Clinical cytometry 2006 Jul 15;70(4):293-301

ZAP-70 expression in B-cell chronic lymphocytic leukemia: evaluation by external (isotypic) or internal (T/NK cells) controls and correlation with IgV(H) mutations.

Zucchetto A, Bomben R, Bo MD, Nanni P, Bulian P, Rossi FM, Del Principe MI, Santini S, Del Poeta G, Degan M, Gattei V
Cytometry. Part B, Clinical cytometry 2006 Jul 15;70(4):284-92

An optimized whole blood method for flow cytometric measurement of ZAP-70 protein expression in chronic lymphocytic leukemia.

Shankey TV, Forman M, Scibelli P, Cobb J, Smith CM, Mills R, Holdaway K, Bernal-Hoyos E, Van Der Heiden M, Popma J, Keeney M
Cytometry. Part B, Clinical cytometry 2006 Jul 15;70(4):259-69

ZAP-70 by flow cytometry: a comparison of different antibodies, anticoagulants, and methods of analysis.

Best OG, Ibbotson RE, Parker AE, Davis ZA, Orchard JA, Oscier DG
Cytometry. Part B, Clinical cytometry 2006 Jul 15;70(4):235-41

A robust ratio metric method for analysis of Zap-70 expression in chronic lymphocytic leukemia (CLL).

Bakke AC, Purtzer Z, Leis J, Huang J
Cytometry. Part B, Clinical cytometry 2006 Jul 15;70(4):227-34

Clinical utility of assessing ZAP-70 and CD38 in chronic lymphocytic leukemia.

Rassenti LZ, Kipps TJ
Cytometry. Part B, Clinical cytometry 2006 Jul 15;70(4):209-13

ZAP-70 in CLL: towards standardization of a biomarker for patient management: history of clinical cytometry special issue.

Marti G, Orfao A, Goolsby C
Cytometry. Part B, Clinical cytometry 2006 Jul 15;70(4):197-200

ZAP-70 is expressed by normal and malignant human B-cell subsets of different maturational stage.

Scielzo C, Camporeale A, Geuna M, Alessio M, Poggi A, Zocchi MR, Chilosi M, Caligaris-Cappio F, Ghia P
Leukemia 2006 Apr;20(4):689-95

Comparison of flow cytometric methods for the measurement of ZAP-70 expression in a routine diagnostic laboratory.

Gibbs G, Bromidge T, Howe D, Hopkins J, Johnson S
Clinical and laboratory haematology 2005 Aug;27(4):258-66

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Supportive validation

Submitted by: Invitrogen Antibodies (provider)
Main image
Experimental details: Western blot analysis of Jurkat cell lysates using Ms anti-ZAP-70 (Product # 37-6500).