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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [6]
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- Product number
- ABIN362163 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70) (pTyr319) antibody
- Antibody type
- Polyclonal
- Antigen
- Peptide sequence around phosphorylation site of pTyr319 (S-P-Y (p) -S-D) derived from Human Zap-70. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
- Description
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Epitope
- pTyr319
- Isotype
- IgG
- Vial size
- 50 μL
- Concentration
- 1 mg/mL
- Storage
- Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Submitted references In vivo correction of ZAP-70 immunodeficiency by intrathymic gene transfer.
Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.
A PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT.
SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling.
Phosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor-dependent phospholipase C-gamma1 and Ras activation.
Enhancement of lymphocyte responsiveness by a gain-of-function mutation of ZAP-70.
Adjali O, Marodon G, Steinberg M, Mongellaz C, Thomas-Vaslin V, Jacquet C, Taylor N, Klatzmann D
The Journal of clinical investigation 2005 Aug;115(8):2287-95
The Journal of clinical investigation 2005 Aug;115(8):2287-95
Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.
Salomon AR, Ficarro SB, Brill LM, Brinker A, Phung QT, Ericson C, Sauer K, Brock A, Horn DM, Schultz PG, Peters EC
Proceedings of the National Academy of Sciences of the United States of America 2003 Jan 21;100(2):443-8
Proceedings of the National Academy of Sciences of the United States of America 2003 Jan 21;100(2):443-8
A PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT.
Ku GM, Yablonski D, Manser E, Lim L, Weiss A
The EMBO journal 2001 Feb 1;20(3):457-65
The EMBO journal 2001 Feb 1;20(3):457-65
SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling.
Tang J, Sawasdikosol S, Chang JH, Burakoff SJ
Proceedings of the National Academy of Sciences of the United States of America 1999 Aug 17;96(17):9775-80
Proceedings of the National Academy of Sciences of the United States of America 1999 Aug 17;96(17):9775-80
Phosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor-dependent phospholipase C-gamma1 and Ras activation.
Williams BL, Irvin BJ, Sutor SL, Chini CC, Yacyshyn E, Bubeck Wardenburg J, Dalton M, Chan AC, Abraham RT
The EMBO journal 1999 Apr 1;18(7):1832-44
The EMBO journal 1999 Apr 1;18(7):1832-44
Enhancement of lymphocyte responsiveness by a gain-of-function mutation of ZAP-70.
Zhao Q, Weiss A
Molecular and cellular biology 1996 Dec;16(12):6765-74
Molecular and cellular biology 1996 Dec;16(12):6765-74
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