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Protein structure
FADD
Fas associated via death domainGIG3, MORT1
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| Proteintech Group |  14906-1-AP |
23 references | Polyclonal |
WB
EL
ICC
IP
IHC
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| Invitrogen Antibodies | 14906-1-AP |
Polyclonal |
WB
ICC
IP
IHC
OA
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| antibodies-online | ABIN395764 |
5 references | Monoclonal |
WB
EL
IHC
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| GeneTex | GTX116064 |
1 references | Polyclonal |
WB
ICC
IHC
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| NovoPro Bioscience Inc. | 110447 |
Polyclonal |
WB
EL
ICC
IP
IHC
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