FADD

gene product
GIG3, MORT1
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]
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428 antibodies from 28 providers.

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AntibodyRefsTypeKDWBELICCIPIHCFC
Abnova Corporation
15 antibodies
Santa Cruz Biotechnology
1 antibody
antibodies-online
165 antibodies
Proteintech Group
1 antibody
Novus Biologicals
19 antibodies
GeneTex
9 antibodies
Biorbyt
21 antibodies
Atlas Antibodies
1 antibody
Cell Signaling Technology, Inc
2 antibodies
Enzo Life Sciences
3 antibodies
Acris Antibodies GmbH
17 antibodies
Aviva Systems Biology
9 antibodies
LifeSpan BioSciences, Inc.
45 antibodies
R&D Systems
2 antibodies
OriGene
1 antibody
Abgent
5 antibodies
Bioworld Technology, Inc
2 antibodies
RabMAbs
8 antibodies
Abbiotec
1 antibody
BosterBio
1 antibody
Creative Biomart
30 antibodies
GenWay
7 antibodies
RayBiotech, Inc.
4 antibodies
EMD Millipore
5 antibodies
Sigma-Aldrich
4 antibodies
Thermo Fisher Scientific Pierce
4 antibodies
United States Biological
10 antibodies