Antibody data
- Antibody Data
- Antigen structure
- References [42]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 14906-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14906-1-AP, RRID:AB_2100486
- Product name
- FADD antibody
- Antibody type
- Polyclonal
- Description
- FADD antibody (Cat. #14906-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references FADD promotes type I interferon production to suppress porcine reproductive and respiratory syndrome virus infection.
LncRNA H19/miR-107 regulates endothelial progenitor cell pyroptosis and promotes flow recovery of lower extremity ischemia through targeting FADD.
Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency.
TNF and IFNγ-induced cell death requires IRF1 and ELAVL1 to promote CASP8 expression.
MiR-21 attenuates FAS-mediated cardiomyocyte apoptosis by regulating HIPK3 expression.
Identification of A novel anoikis-related genes-based signature for non-small cell lung cancer.
Quizartinib inhibits necroptosis by targeting receptor-interacting serine/threonine protein kinase 1.
PKM2/PDK1 dual-targeted shikonin derivatives restore the sensitivity of EGFR-mutated NSCLC cells to gefitinib by remodeling glucose metabolism.
Low-density small extracellular vesicles in bovine follicular fluid carrying let-7i target FASLG to inhibit granulosa cells apoptosis.
Silencing of FAM111B inhibits tumor growth and promotes apoptosis by decreasing AKT activity in ovarian cancer.
Effects of Treadmill Exercise on Liver Apoptosis in Fluoride-Exposed Mice.
EGFR-TNFR1 pathway in endothelial cell facilitates acute lung injury by NF-κB/MAPK-mediated inflammation and RIP3-dependent necroptosis.
Structural Characterization and Anti-breast Cancer Activity in vitro of a Novel Polysaccharide From Cymbopogon citratus.
Fructose Induces Insulin Resistance of Gestational Diabetes Mellitus in Mice via the NLRP3 Inflammasome Pathway.
Mannan-Binding Lectin Deficiency Limits Inflammation-induced Myeloid-Derived Suppressor Cells Expansion via Modulating Tumor Necrosis Factor Alpha-triggered Apoptosis.
A causal variant rs3769823 in 2q33.1 involved in apoptosis pathway leading to a decreased risk of non-small cell lung cancer.
Astragaloside IV Inhibits the Proliferation of Human Uterine Leiomyomas by Targeting IDO1.
N-acetylserotonin protects PC12 cells from hydrogen peroxide induced damage through ROS mediated PI3K / AKT pathway.
Human breast milk-derived exosomes through inhibiting AT II cell apoptosis to prevent bronchopulmonary dysplasia in rat lung.
Crosstalk Between NDP52 and LUBAC in Innate Immune Responses, Cell Death, and Xenophagy.
The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8.
MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIP(L).
Calcium alleviates fluoride-induced kidney damage via FAS/FASL, TNFR/TNF, DR5/TRAIL pathways in rats.
Nuclear respiratory factor 1 protects H9C2 cells against hypoxia-induced apoptosis via the death receptor pathway and mitochondrial pathway.
A unique death pathway keeps RIPK1 D325A mutant mice in check at embryonic day 10.5.
ROS-mediated PERK-eIF2α-ATF4 pathway plays an important role in arsenite-induced L-02 cells apoptosis via regulating CHOP-DR5 signaling.
Protective effect of astaxanthin against SnS(2) nanoflowers induced testes toxicity by suppressing RIPK1-RIPK3-MLKL signaling in mice.
Palmatine induces G2/M phase arrest and mitochondrial-associated pathway apoptosis in colon cancer cells by targeting AURKA.
Hic-5 deficiency attenuates hepatic ischemia reperfusion injury through TLR4/NF-κB signaling pathways.
Novel HSP90-PI3K Dual Inhibitor Suppresses Melanoma Cell Proliferation by Interfering with HSP90-EGFR Interaction and Downstream Signaling Pathways.
Synergetic inhibition of daidzein and regular exercise on breast cancer in bearing-4T1 mice by regulating NK cells and apoptosis pathway.
Aconitine induces cardiomyocyte damage by mitigating BNIP3-dependent mitophagy and the TNFα-NLRP3 signalling axis.
Long noncoding RNA UBE2R2-AS1 promotes glioma cell apoptosis via targeting the miR-877-3p/TLR4 axis.
SPOP inhibits mice pancreatic stellate cell activation by promoting FADD degradation in cerulein-induced chronic pancreatitis.
Glucocorticoid modulatory element-binding protein 1 (GMEB1) interacts with the de-ubiquitinase USP40 to stabilize CFLAR(L) and inhibit apoptosis in human non-small cell lung cancer cells.
A novel biphenyl urea compound, TPD7, stimulates apoptosis through modulating Fas signaling and Bcl-2 family proteins in cervical cancer.
Protective effect of mild-induced hypothermia against moderate traumatic brain injury in rats involved in necroptotic and apoptotic pathways.
Capsular Polysaccharide of Mycoplasma ovipneumoniae Induces Sheep Airway Epithelial Cell Apoptosis via ROS-Dependent JNK/P38 MAPK Pathways.
TRAIL Deletion Prevents Liver, but Not Adipose Tissue, Inflammation during Murine Diet-Induced Obesity.
Non-hemolytic enterotoxin of Bacillus cereus induces apoptosis in Vero cells.
Dynamic quantitative proteomics characterization of TNF-α-induced necroptosis.
miR-155 inhibits oxidized low-density lipoprotein-induced apoptosis of RAW264.7 cells.
Chang X, Wang M, Li Z, Wang L, Zhang G, Chang Y, Hu J
Frontiers in veterinary science 2024;11:1380144
Frontiers in veterinary science 2024;11:1380144
LncRNA H19/miR-107 regulates endothelial progenitor cell pyroptosis and promotes flow recovery of lower extremity ischemia through targeting FADD.
Huang L, Ye Y, Sun Y, Zhou Z, Deng T, Liu Y, Wu R, Wang K, Yao C
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167323
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167323
Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency.
Oda H, Manthiram K, Chavan PP, Rieser E, Veli Ö, Kaya Ö, Rauch C, Nakabo S, Kuehn HS, Swart M, Wang Y, Çelik NI, Molitor A, Ziaee V, Movahedi N, Shahrooei M, Parvaneh N, Alipour-Olyei N, Carapito R, Xu Q, Preite S, Beck DB, Chae JJ, Nehrebecky M, Ombrello AK, Hoffmann P, Romeo T, Deuitch NT, Matthíasardóttir B, Mullikin J, Komarow H, Stoddard J, Niemela J, Dobbs K, Sweeney CL, Anderton H, Lawlor KE, Yoshitomi H, Yang D, Boehm M, Davis J, Mudd P, Randazzo D, Tsai WL, Gadina M, Kaplan MJ, Toguchida J, Mayer CT, Rosenzweig SD, Notarangelo LD, Iwai K, Silke J, Schwartzberg PL, Boisson B, Casanova JL, Bahram S, Rao AP, Peltzer N, Walczak H, Lalaoui N, Aksentijevich I, Kastner DL
Nature immunology 2024 May;25(5):764-777
Nature immunology 2024 May;25(5):764-777
TNF and IFNγ-induced cell death requires IRF1 and ELAVL1 to promote CASP8 expression.
Deng B, Wang J, Yang T, Deng Z, Yuan J, Zhang B, Zhou Z, Chen F, Fang L, Liang C, Yan B, Ai Y
The Journal of cell biology 2024 Mar 4;223(3)
The Journal of cell biology 2024 Mar 4;223(3)
MiR-21 attenuates FAS-mediated cardiomyocyte apoptosis by regulating HIPK3 expression.
Wang X, Zhang T, Zhai J, Wang Z, Wang Y, He L, Ma S, Xing H, Guo Y
Bioscience reports 2023 Sep 27;43(9)
Bioscience reports 2023 Sep 27;43(9)
Identification of A novel anoikis-related genes-based signature for non-small cell lung cancer.
Lei J, Guo G, Liang D, Gong L, Zhang L, Wang X
Biochemical and biophysical research communications 2023 Sep 17;673:137-144
Biochemical and biophysical research communications 2023 Sep 17;673:137-144
Quizartinib inhibits necroptosis by targeting receptor-interacting serine/threonine protein kinase 1.
Li M, Wei J, Zhu G, Fu S, He X, Hu X, Yu Y, Mou Y, Wang J, You X, Xiao X, Gu T, Ye Z, Zha Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Oct;37(10):e23178
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Oct;37(10):e23178
PKM2/PDK1 dual-targeted shikonin derivatives restore the sensitivity of EGFR-mutated NSCLC cells to gefitinib by remodeling glucose metabolism.
Lin H, Han H, Yang M, Wen Z, Chen Q, Ma Y, Wang X, Wang C, Yin T, Wang X, Lu G, Chen H, Qi J, Yang Y
European journal of medicinal chemistry 2023 Mar 5;249:115166
European journal of medicinal chemistry 2023 Mar 5;249:115166
Low-density small extracellular vesicles in bovine follicular fluid carrying let-7i target FASLG to inhibit granulosa cells apoptosis.
Zhao Y, Wang Y, Ling Z, Xue Y, Luan D, Kang J, Zhang Y, Quan F
Theriogenology 2023 Mar 15;199:121-130
Theriogenology 2023 Mar 15;199:121-130
Silencing of FAM111B inhibits tumor growth and promotes apoptosis by decreasing AKT activity in ovarian cancer.
Wang W, Gu Y, Ni H, Quan Q, Guo L
Experimental biology and medicine (Maywood, N.J.) 2023 Jun;248(12):1043-1055
Experimental biology and medicine (Maywood, N.J.) 2023 Jun;248(12):1043-1055
Effects of Treadmill Exercise on Liver Apoptosis in Fluoride-Exposed Mice.
Liu K, Chai L, Zhao T, Zhang S, Wang J, Yu Y, Niu R, Sun Z
Biological trace element research 2023 Dec;201(12):5734-5746
Biological trace element research 2023 Dec;201(12):5734-5746
EGFR-TNFR1 pathway in endothelial cell facilitates acute lung injury by NF-κB/MAPK-mediated inflammation and RIP3-dependent necroptosis.
Zhang H, Zhang X, Ling C, Liu C, Hua S, Xiong Z, Zhao H, Feng Q, Feng Z, Tang J, Hong X
International immunopharmacology 2023 Apr;117:109902
International immunopharmacology 2023 Apr;117:109902
Structural Characterization and Anti-breast Cancer Activity in vitro of a Novel Polysaccharide From Cymbopogon citratus.
Chen Y, Qiao S, Liu H, Xing H, Chen P
Frontiers in nutrition 2022;9:911838
Frontiers in nutrition 2022;9:911838
Fructose Induces Insulin Resistance of Gestational Diabetes Mellitus in Mice via the NLRP3 Inflammasome Pathway.
Liu Y, Wei Y, Wu L, Lin X, Sun R, Chen H, Shen S, Deng G
Frontiers in nutrition 2022;9:839174
Frontiers in nutrition 2022;9:839174
Mannan-Binding Lectin Deficiency Limits Inflammation-induced Myeloid-Derived Suppressor Cells Expansion via Modulating Tumor Necrosis Factor Alpha-triggered Apoptosis.
Dong L, Jiang H, Chen K, Xie J, An Q, Deng F, Sun Z, Liu Y, Zhou J, Zhang L, Lu X, Wang M, Chen Z, Zou X, Zuo D
International journal of biological sciences 2022;18(4):1580-1593
International journal of biological sciences 2022;18(4):1580-1593
A causal variant rs3769823 in 2q33.1 involved in apoptosis pathway leading to a decreased risk of non-small cell lung cancer.
Zhang X, Qin N, Fan J, Zhang C, Sun Q, Gu Y, Zhu M, Zhang E, Dai J, Jin G, Ma H, Hu Z, Shen H
Cancer biology & medicine 2022 Sep 2;19(9):1385-96
Cancer biology & medicine 2022 Sep 2;19(9):1385-96
Astragaloside IV Inhibits the Proliferation of Human Uterine Leiomyomas by Targeting IDO1.
Qiu T, Li D, Liu Y, Ren H, Yang X, Luo W
Cancers 2022 Sep 12;14(18)
Cancers 2022 Sep 12;14(18)
N-acetylserotonin protects PC12 cells from hydrogen peroxide induced damage through ROS mediated PI3K / AKT pathway.
Kang J, Wang Y, Guo X, He X, Liu W, Chen H, Wang Z, Lin A, Kang X
Cell cycle (Georgetown, Tex.) 2022 Nov;21(21):2268-2282
Cell cycle (Georgetown, Tex.) 2022 Nov;21(21):2268-2282
Human breast milk-derived exosomes through inhibiting AT II cell apoptosis to prevent bronchopulmonary dysplasia in rat lung.
Zhou Y, Liu Y, Xu G, Liu L, Li H, Li Y, Yin J, Wang X, Yu Z
Journal of cellular and molecular medicine 2022 Aug;26(15):4169-4182
Journal of cellular and molecular medicine 2022 Aug;26(15):4169-4182
Crosstalk Between NDP52 and LUBAC in Innate Immune Responses, Cell Death, and Xenophagy.
Miyashita H, Oikawa D, Terawaki S, Kabata D, Shintani A, Tokunaga F
Frontiers in immunology 2021;12:635475
Frontiers in immunology 2021;12:635475
The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8.
Zhang JY, Zhou B, Sun RY, Ai YL, Cheng K, Li FN, Wang BR, Liu FJ, Jiang ZH, Wang WJ, Zhou D, Chen HZ, Wu Q
Cell research 2021 Sep;31(9):980-997
Cell research 2021 Sep;31(9):980-997
MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIP(L).
Nakabayashi O, Takahashi H, Moriwaki K, Komazawa-Sakon S, Ohtake F, Murai S, Tsuchiya Y, Koyahara Y, Saeki Y, Yoshida Y, Yamazaki S, Tokunaga F, Sawasaki T, Nakano H
Communications biology 2021 Jan 19;4(1):80
Communications biology 2021 Jan 19;4(1):80
Calcium alleviates fluoride-induced kidney damage via FAS/FASL, TNFR/TNF, DR5/TRAIL pathways in rats.
Li H, Fan J, Zhao Y, Yang J, Xu H, Manthari RK, Cheng X, Wang J, Wang J
Ecotoxicology and environmental safety 2021 Dec 15;226:112851
Ecotoxicology and environmental safety 2021 Dec 15;226:112851
Nuclear respiratory factor 1 protects H9C2 cells against hypoxia-induced apoptosis via the death receptor pathway and mitochondrial pathway.
Li H, Niu N, Yang J, Dong F, Zhang T, Li S, Zhao W
Cell biology international 2021 Aug;45(8):1784-1796
Cell biology international 2021 Aug;45(8):1784-1796
A unique death pathway keeps RIPK1 D325A mutant mice in check at embryonic day 10.5.
Zhang Y, Huang K, Zhang Y, Han T, Li L, Ruan C, Sun YH, Shi W, Han W, Wu SQ, Song J, Liu J, Han J
PLoS biology 2021 Aug;19(8):e3001304
PLoS biology 2021 Aug;19(8):e3001304
ROS-mediated PERK-eIF2α-ATF4 pathway plays an important role in arsenite-induced L-02 cells apoptosis via regulating CHOP-DR5 signaling.
Liu C, Zhang A
Environmental toxicology 2020 Oct;35(10):1100-1113
Environmental toxicology 2020 Oct;35(10):1100-1113
Protective effect of astaxanthin against SnS(2) nanoflowers induced testes toxicity by suppressing RIPK1-RIPK3-MLKL signaling in mice.
Yuan L, Liang P, Qu Y, An T, Wang J, Deng X, Bai L, Shen P, Bai D
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Nov;145:111736
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Nov;145:111736
Palmatine induces G2/M phase arrest and mitochondrial-associated pathway apoptosis in colon cancer cells by targeting AURKA.
Liu X, Zhang Y, Wu S, Xu M, Shen Y, Yu M, Fan J, Wei S, Xu C, Huang L, Zhao H, Li X, Ye X
Biochemical pharmacology 2020 May;175:113933
Biochemical pharmacology 2020 May;175:113933
Hic-5 deficiency attenuates hepatic ischemia reperfusion injury through TLR4/NF-κB signaling pathways.
Gao L, Qian B, Chen H, Wang A, Li Q, Li J, Tan P, Xia X, Du Y, Fu W
Life sciences 2020 May 15;249:117517
Life sciences 2020 May 15;249:117517
Novel HSP90-PI3K Dual Inhibitor Suppresses Melanoma Cell Proliferation by Interfering with HSP90-EGFR Interaction and Downstream Signaling Pathways.
Zhao Q, Zhu HP, Xie X, Mao Q, Liu YQ, He XH, Peng C, Jiang QL, Huang W
International journal of molecular sciences 2020 Mar 7;21(5)
International journal of molecular sciences 2020 Mar 7;21(5)
Synergetic inhibition of daidzein and regular exercise on breast cancer in bearing-4T1 mice by regulating NK cells and apoptosis pathway.
Wang B, Xu H, Hu X, Ma W, Zhang J, Li Y, Yu M, Zhang Y, Li X, Ye X
Life sciences 2020 Mar 15;245:117387
Life sciences 2020 Mar 15;245:117387
Aconitine induces cardiomyocyte damage by mitigating BNIP3-dependent mitophagy and the TNFα-NLRP3 signalling axis.
Peng F, Zhang N, Wang C, Wang X, Huang W, Peng C, He G, Han B
Cell proliferation 2020 Jan;53(1):e12701
Cell proliferation 2020 Jan;53(1):e12701
Long noncoding RNA UBE2R2-AS1 promotes glioma cell apoptosis via targeting the miR-877-3p/TLR4 axis.
Xu W, Hu GQ, Da Costa C, Tang JH, Li QR, Du L, Pan YW, Lv SQ
OncoTargets and therapy 2019;12:3467-3480
OncoTargets and therapy 2019;12:3467-3480
SPOP inhibits mice pancreatic stellate cell activation by promoting FADD degradation in cerulein-induced chronic pancreatitis.
Tan P, Wang A, Chen H, Du Y, Qian B, Shi H, Zhang Y, Xia X, Fu W
Experimental cell research 2019 Nov 1;384(1):111606
Experimental cell research 2019 Nov 1;384(1):111606
Glucocorticoid modulatory element-binding protein 1 (GMEB1) interacts with the de-ubiquitinase USP40 to stabilize CFLAR(L) and inhibit apoptosis in human non-small cell lung cancer cells.
An W, Yao S, Sun X, Hou Z, Lin Y, Su L, Liu X
Journal of experimental & clinical cancer research : CR 2019 May 2;38(1):181
Journal of experimental & clinical cancer research : CR 2019 May 2;38(1):181
A novel biphenyl urea compound, TPD7, stimulates apoptosis through modulating Fas signaling and Bcl-2 family proteins in cervical cancer.
Zhan Y, Zhang H, Dai B, Zhang Y, Zhang J, He L
Oncology reports 2018 Aug;40(2):1064-1072
Oncology reports 2018 Aug;40(2):1064-1072
Protective effect of mild-induced hypothermia against moderate traumatic brain injury in rats involved in necroptotic and apoptotic pathways.
Zhang HB, Cheng SX, Tu Y, Zhang S, Hou SK, Yang Z
Brain injury 2017;31(3):406-415
Brain injury 2017;31(3):406-415
Capsular Polysaccharide of Mycoplasma ovipneumoniae Induces Sheep Airway Epithelial Cell Apoptosis via ROS-Dependent JNK/P38 MAPK Pathways.
Jiang Z, Song F, Li Y, Xue D, Zhao N, Zhang J, Deng G, Li M, Liu X, Wang Y
Oxidative medicine and cellular longevity 2017;2017:6175841
Oxidative medicine and cellular longevity 2017;2017:6175841
TRAIL Deletion Prevents Liver, but Not Adipose Tissue, Inflammation during Murine Diet-Induced Obesity.
Hirsova P, Weng P, Salim W, Bronk SF, Griffith TS, Ibrahim SH, Gores GJ
Hepatology communications 2017 Sep;1(7):648-662
Hepatology communications 2017 Sep;1(7):648-662
Non-hemolytic enterotoxin of Bacillus cereus induces apoptosis in Vero cells.
Liu X, Ding S, Shi P, Dietrich R, Märtlbauer E, Zhu K
Cellular microbiology 2017 Apr;19(4)
Cellular microbiology 2017 Apr;19(4)
Dynamic quantitative proteomics characterization of TNF-α-induced necroptosis.
Wang Y, Huang ZH, Li YJ, He GW, Yu RY, Yang J, Liu WT, Li B, He QY
Apoptosis : an international journal on programmed cell death 2016 Dec;21(12):1438-1446
Apoptosis : an international journal on programmed cell death 2016 Dec;21(12):1438-1446
miR-155 inhibits oxidized low-density lipoprotein-induced apoptosis of RAW264.7 cells.
Zhu GF, Yang LX, Guo RW, Liu H, Shi YK, Wang H, Ye JS, Yang ZH, Liang X
Molecular and cellular biochemistry 2013 Oct;382(1-2):253-61
Molecular and cellular biochemistry 2013 Oct;382(1-2):253-61
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HT-1080 cells were subjected to SDS PAGE followed by western blot with 14906-1-AP( FADD Antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-FADD (IP:14906-1-AP, 3ug; Detection:14906-1-AP 1:200) with A549 cells lysate 1200ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human lung cancer using 14906-1-AP(FADD antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The FADD antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human FADD. This antibody recognizes human,mouse,rat antigen. The FADD antibody has been validated for the following applications: ELISA, IHC, IP, WB analysis.