INTS6

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and is located in the critical region of loss of heterozygosity (LOH). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2015]

Description

Integrator complex subunit 6

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Actin filaments

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

13 (51354077 - 51454264)

Ensembl ID

ENSG00000102786  (ver. 103.38)

Orthologs

Mouse Ints6: ENSMUSG00000035161

UniProt

Q9UL03

neXtProt

NX_Q9UL03

Human splice variants
Mouse splice variants

Protein structure