BS4251

antibody from Bioworld Technology, Inc

Targeting: SHC1 p66, SHC, ShcA

Immunohistochemistry

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Validation data

Product number: BS4251 - Provider product page
Provider: Bioworld Technology, Inc
Product name: Shc (phospho Y427) polyclonal antibody
Antibody type: Polyclonal
Antigen: Synthetic phosphopeptide derived from human Shc around the phosphorylation site of Tyrosine 427.
Description: Critical components of this process include adapter proteins such as Shc and IRS-1 that lack detectable catalytic activity. These are immediate substrates of receptor tyrosine kinase activity and serve to physically link activated receptors to downstream signaling components. Whereas Shc has been implicated in signaling by diverse receptor families, IRS-1 serves primarily as the major insulin receptor substrate. Shc also participates in insulin signaling by linking the insulin receptor to Ras by forming complexes with the adapter protein GRB2 and Sos independently of IRS-1. A protein immunologically related to IRS-1, originally designated 4PS and now known as IRS-2, was shown to become highly tyrosine phosphorylated in response to IL-4 or IGF-1 in cells lacking IRS-1. An additional member of this family of signaling intermediates, Shb, is a SH2-containing protein with characteristic proline-rich domains.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Vial size: 100ul
Concentration: 1 mg/ml
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SHC1 protein structure - BS4251 shown in red.