SHC1

gene product
p66, SHC
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
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419 antibodies from 29 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
antibodies-online
142 antibodies
Santa Cruz Biotechnology
2 antibodies
Novus Biologicals
33 antibodies
Abnova Corporation
8 antibodies
Acris Antibodies GmbH
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LifeSpan BioSciences, Inc.
51 antibodies
Bethyl Laboratories, Inc.
3 antibodies
Proteintech Group
2 antibodies
GeneTex
19 antibodies
OriGene
4 antibodies
Signalway Antibody LLC
4 antibodies
Thermo Fisher Scientific Pierce
4 antibodies
Aviva Systems Biology
10 antibodies
Enzo Life Sciences
5 antibodies
Cell Signaling Technology, Inc
3 antibodies
RayBiotech, Inc.
3 antibodies
Boster Immunoleader Biotechnology
1 antibody
Creative Biomart
35 antibodies
RabMAbs
6 antibodies
Atlas Antibodies
1 antibody
R&D Systems
1 antibody
Biorbyt
7 antibodies
Bioworld Technology, Inc
4 antibodies
United States Biological
26 antibodies
Abiocode, Inc.
2 antibodies
EMD Millipore
4 antibodies
Sigma-Aldrich
4 antibodies
BioLegend
1 antibody
GenWay
6 antibodies