Tissue expression
Cell line expression
Protein structure
CCL5
C-C motif chemokine ligand 5D17S136E, MGC17164, RANTES, SCYA5, SISd, TCP228
This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
Top validated antibodies |
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R&D Systems | AF-278-NA | 22 references | Polyclonal |
WB
ICC
IHC
BN |
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Novus Biologicals | AF-278-NA | 22 references | Polyclonal |
WB
ICC
IHC
BN |
|
Invitrogen Antibodies | 710001 | 4 references | Polyclonal |
WB
ICC
IHC
OA |
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OriGene | SM1416P | Monoclonal |
WB
EL
ICC
IP
IHC
FA |
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GeneTex | GTX31207 | 1 references | Polyclonal |
WB
EL
IHC
BN |
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