Antibody data
- Antibody Data
- Antigen structure
- References [5]
- Comments [0]
- Validations [0]
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- Product number
- ABIN362618 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) (AA 1219-1223) antibody
- Antibody type
- Polyclonal
- Antigen
- Peptide sequence around AA 1219-1223, 1220-1224 (N-L-Y-Y -W) derived from Human HER2. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
- Description
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen.
- Reactivity
- Human
- Host
- Rabbit
- Epitope
- AA 1219-1223
- Isotype
- IgG
- Vial size
- 100 μL
- Concentration
- 1 mg/mL
- Storage
- Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Submitted references Memo mediates ErbB2-driven cell motility.
ErbB-2 activates Stat3 alpha in a Src- and JAK2-dependent manner.
Tumor-inhibitory antibodies to HER-2/ErbB-2 may act by recruiting c-Cbl and enhancing ubiquitination of HER-2.
The duration of phorbol-inducible ErbB2 tyrosine dephosphorylation parallels that of receptor endocytosis rather than threonine-686 phosphorylation: implications for the physiological role of protein kinase C in growth factor receptor signalling.
Adjacent carboxyterminal tyrosine phosphorylation events identify functionally distinct ErbB2 receptor subsets: implications for molecular diagnostics.
Marone R, Hess D, Dankort D, Muller WJ, Hynes NE, Badache A
Nature cell biology 2004 Jun;6(6):515-22
Nature cell biology 2004 Jun;6(6):515-22
ErbB-2 activates Stat3 alpha in a Src- and JAK2-dependent manner.
Ren Z, Schaefer TS
The Journal of biological chemistry 2002 Oct 11;277(41):38486-93
The Journal of biological chemistry 2002 Oct 11;277(41):38486-93
Tumor-inhibitory antibodies to HER-2/ErbB-2 may act by recruiting c-Cbl and enhancing ubiquitination of HER-2.
Klapper LN, Waterman H, Sela M, Yarden Y
Cancer research 2000 Jul 1;60(13):3384-8
Cancer research 2000 Jul 1;60(13):3384-8
The duration of phorbol-inducible ErbB2 tyrosine dephosphorylation parallels that of receptor endocytosis rather than threonine-686 phosphorylation: implications for the physiological role of protein kinase C in growth factor receptor signalling.
Ouyang X, Gulliford T, Epstein RJ
Carcinogenesis 1998 Nov;19(11):2013-9
Carcinogenesis 1998 Nov;19(11):2013-9
Adjacent carboxyterminal tyrosine phosphorylation events identify functionally distinct ErbB2 receptor subsets: implications for molecular diagnostics.
Ouyang X, Huang GC, Chantry A, Epstein RJ
Experimental cell research 1998 Jun 15;241(2):467-75
Experimental cell research 1998 Jun 15;241(2):467-75
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