CABT-L827

antibody from Creative Diagnostics

Targeting: IL1B IL-1B, IL1-BETA, IL1F2

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Antibody Data

Product number

CABT-L827

Provider

Creative Diagnostics

Product name

Rabbit Anti-Human Il1b monoclonal antibody, clone KK198-4

Antibody type

Monoclonal

Description

Two forms of interleukin-1, designated IL-1Ï« and IL-1ÉÇ, have been described. Although encoded by distinct genes and exhibiting roughly only 25% sequence identity, IL-1Ï« and IL-1ÉÇ bind to the same receptor and seem to elicit similar biological responses. IL-1 production is generally thought to be associated with inflammation, but it has also been shown to be expressed during kidney development, thymocyte differentiation and cartilage degradation. IL-1 plays a critical role in the regulation of immune response and inflammation, acting as an activator of T and B lymphocytes and natural killer (NK) cells. In T cells, IL-1 stimulates the production of IL-2 and selectively inhibits IL-4 expression. IL-1 induces B cell proliferation and maturation, and immunoglobulin synthesis. NK cells require IL-1ÉÇ for production of the anti- pathogen IFN-ÎÛ. IL-1 has also been implicated in several pathological conditions including rheumatoid arthritis, inflammatory bowel disease and atherosclerosis.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

KK198-4

Vial size

100 _l

Storage

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.