MYH7B

The myosin II molecule is a multi-subunit complex consisting of two heavy chains and four light chains. This gene encodes a heavy chain of myosin II, which is a member of the motor-domain superfamily. The heavy chain includes a globular motor domain, which catalyzes ATP hydrolysis and interacts with actin, and a tail domain in which heptad repeat sequences promote dimerization by interacting to form a rod-like alpha-helical coiled coil. This heavy chain subunit is a slow-twitch myosin. Alternatively spliced transcript variants have been found, but the full-length nature of these variants is not determined. [provided by RefSeq, Mar 2010]

Description

Myosin heavy chain 7B

Tissue specificity

Group enriched (heart muscle, skeletal muscle)

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

20 (34955810 - 35002437)

Ensembl ID

ENSG00000078814  (ver. 103.38)

Orthologs

Mouse Myh7b: ENSMUSG00000074652

UniProt

A7E2Y1

neXtProt

NX_A7E2Y1

Human splice variants
Mouse splice variants

Protein structure