PGR

This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Sep 2015]

Description

Progesterone receptor

Tissue specificity

Group enriched (cervix, endometrium , fallopian tube, smooth muscle)

Predicted location

Intracellular

Protein family

Cancer-related genes
FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Nuclear receptors
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transcription factors
Transporters

Chromosome

11 (101029624 - 101129813)

Ensembl ID

ENSG00000082175  (ver. 103.38)

Orthologs

Mouse Pgr: ENSMUSG00000031870

UniProt

P06401

neXtProt

NX_P06401

Human splice variants
Mouse splice variants

Protein structure