CACNA1I

This gene encodes the pore-forming alpha subunit of a voltage gated calcium channel. The encoded protein is a member of a subfamily of calcium channels referred to as is a low voltage-activated, T-type, calcium channel. The channel encoded by this protein is characterized by a slower activation and inactivation compared to other T-type calcium channels. This protein may be involved in calcium signaling in neurons. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]

Description

Calcium voltage-gated channel subunit alpha1 I

Tissue specificity

Tissue enhanced (brain, thyroid gland)

Subcell location

Plasma membrane, Cell Junctions

Predicted location

Membrane

Protein family

FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transporters
Voltage-gated ion channels

Chromosome

22 (39570753 - 39689735)

Ensembl ID

ENSG00000100346  (ver. 103.38)

Orthologs

Mouse Cacna1i: ENSMUSG00000022416

UniProt

Q9P0X4

neXtProt

NX_Q9P0X4

Human splice variants
Mouse splice variants

Protein structure