COBL

This gene encodes a protein that contains WH2 domains (WASP, Wiskott-Aldrich syndrome protein, homology domain-2) that interact with actin. The encoded actin regulator protein is required for growth and assembly of brush border microvilli that play a role in maintaining intestinal homeostasis. A similar protein in mouse functions in midbrain neural tube closure. A pseudogene of this gene is located on chromosome X. [provided by RefSeq, Oct 2016]

Description

Cordon-bleu WH2 repeat protein

Tissue specificity

Tissue enhanced (brain, skeletal muscle, tongue)

Subcell location

Plasma membrane, Cell Junctions

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

7 (51016212 - 51316818)

Ensembl ID

ENSG00000106078  (ver. 103.38)

Orthologs

Mouse Cobl: ENSMUSG00000020173

UniProt

O75128

neXtProt

NX_O75128

Human splice variants
Mouse splice variants

Protein structure