Explore
Validate
LearnTissue expression
Cell line expression
Protein structure
CBLB
Cbl proto-oncogene BCbl-b, RNF56
This gene encodes an E3 ubiquitin-protein ligase which promotes proteosome-mediated protein degradation by transferring ubiquitin from an E2 ubiquitin-conjugating enzyme to a substrate. The encoded protein is involved in the regulation of immune response by limiting T-cell receptor, B-cell receptor, and high affinity immunoglobulin epsilon receptor activation. Studies in mouse suggest that this gene is involved in antifungal host defense and that its inhibition leads to increased fungal killing. Manipulation of this gene may be beneficial in implementing immunotherapies for a variety of conditions, including cancer, autoimmune diseases, allergies, and infections. [provided by RefSeq, Sep 2017]
Top validated antibodies |
|||||
| Proteintech Group |  12781-1-AP |
7 references | Polyclonal |
WB
EL
ICC
IP
IHC
|
|
| antibodies-online | ABIN2842410 |
2 references | Polyclonal |
WB
IHC
FC
|
|
| Invitrogen Antibodies | 12781-1-AP |
Polyclonal |
WB
IP
IHC
FC
OA
|
||
| NovoPro Bioscience Inc. | 108899 |
Polyclonal |
WB
EL
ICC
IP
IHC
|
||
| Aviva Systems Biology | OAAB05263 |
Polyclonal |
WB
EL
IHC
FC
|
||
All Antibodies
Filters
Enhanced validation Supportive data in Antibodypedia Data presented on provider website
Data in Antibodypedia (inconclusive) Recommended by provider