Tissue expression
Cell line expression
Protein structure
TNFRSF10B
TNF receptor superfamily member 10bCD262, DR5, KILLER, TRAIL-R2, TRAILR2, TRICK2A, TRICKB
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]
Top validated antibodies |
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Novus Biologicals | NB100-55744 | 20 references | Polyclonal |
WB
ICC
IHC
FC
IEM
|
|
Invitrogen Antibodies | PA1-957 | 5 references | Polyclonal |
WB
ICC
FC
OA |
|
R&D Systems | AF721 | 3 references | Polyclonal |
WB
FC
BN
|
|
Enzo Life Sciences | ALX-210-743-C200 | 9 references | Polyclonal |
WB
ICC
IHC
FC |
|
Biorbyt | orb1272937 | Monoclonal |
ICC
IP
IHC
FC
FA
|
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