Tissue expression
Cell line expression
Protein structure
TNFRSF10B
TNF receptor superfamily member 10bCD262, DR5, KILLER, TRAIL-R2, TRAILR2, TRICK2A, TRICKB
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]
Top validated antibodies |
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Novus Biologicals | ![]() |
20 references | Polyclonal |
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Invitrogen Antibodies | ![]() |
5 references | Polyclonal |
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LSBio | ![]() |
Monoclonal |
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R&D Systems | ![]() |
3 references | Polyclonal |
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Enzo Life Sciences | ![]() |
9 references | Polyclonal |
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