PKN1

The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Description

Protein kinase N1

Tissue specificity

Low tissue specificity

Subcell location

Plasma membrane, Cytokinetic bridge

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

19 (14433053 - 14471867)

Ensembl ID

ENSG00000123143  (ver. 103.38)

Orthologs

Mouse Pkn1: ENSMUSG00000057672

UniProt

Q16512

neXtProt

NX_Q16512

Human splice variants
Mouse splice variants

Protein structure