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Protein structure
ACE2
Angiotensin I converting enzyme 2The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. ACE2 is known to be expressed in various human organs, and its organ- and cell-specific expression suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2, the latter is the causative agent of coronavirus disease-2019 (COVID-19). Multiple splice variants have been found for this gene and the dACE2 (or MIRb-ACE2) splice variant has been found to be interferon inducible. [provided by RefSeq, Nov 2020]
Top validated antibodies |
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| Proteintech Group |  21115-1-AP |
117 references | Polyclonal |
WB
EL
ICC
IP
IHC
FC
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| Invitrogen Antibodies | PA5-47488 |
5 references | Polyclonal |
WB
EL
IP
IHC
FC
OA
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| Novus Biologicals | AF933 |
22 references | Polyclonal |
WB
IP
IHC
FC
BN
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| R&D Systems | AF933 |
19 references | Polyclonal |
WB
IP
IHC
FC
BN
|
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| LSBio | LS-A13632 |
Polyclonal |
WB
EL
IHC
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