ITGAX

This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Description

Integrin subunit alpha X

Tissue specificity

Tissue enhanced (bone marrow, lung, lymphoid tissue)

Predicted location

Intracellular, Membrane

Protein family

CD markers
FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

16 (31355134 - 31382999)

Ensembl ID

ENSG00000140678  (ver. 103.38)

Orthologs

Mouse Itgax: ENSMUSG00000030789

UniProt

P20702

neXtProt

NX_P20702

Human splice variants
Mouse splice variants

Protein structure