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Protein structure
ERLIN2
ER lipid raft associated 2C8orf2, Erlin-2, NET32, SPFH2, SPG18
This gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia-18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
Top validated antibodies |
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| LSBio |  LS-C185779 |
Polyclonal |
WB
IHC
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| Novus Biologicals | NB100-1884 |
3 references | Polyclonal |
WB
EL
IHC
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| NSJ Bioreagents | RQ7117 |
Monoclonal |
WB
ICC
IHC
FC
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| Proteintech Group | 14781-1-AP |
2 references | Polyclonal |
WB
EL
IHC
|
|
| Atlas Antibodies | HPA002025 |
5 references | Polyclonal |
WB
ICC
IHC
|
|
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