Tissue expression
Cell line expression
Protein structure
GRID2
Glutamate ionotropic receptor delta type subunit 2GluD2, GluR-delta-2
The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans. [provided by RefSeq, Apr 2014]
Top validated antibodies |
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Biorbyt | orb157182 | Polyclonal |
WB
EL
ICC
IHC |
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Invitrogen Antibodies | PA5-115325 | Polyclonal |
WB
ICC
IHC
|
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NSJ Bioreagents | RQ6096 | Polyclonal |
WB
IHC
FC
|
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Boster Biological Technology | A05305-2 | Polyclonal |
WB
IHC
FC
|
||
St John's Laboratory | STJ93292 | Polyclonal |
WB
EL
ICC
IHC |
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Supportive data in Antibodypedia
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Recommended by provider